Adrenal agents Flashcards
what are the drug targets of corticosteroids?
17a-hydroxylase
11B-hydroxylase
17a-hydroxylase is responsible for catalyzing what reactions?
pregnenolone to 17-hydroxypregnenolone
progesterone to 17-hydroxyprogesterone
11B-hydroxylase is responsible for catalyzing what reaction?
deoxycortisone to cortisone
what enzyme is responsible for catalyzing the reactions
pregnenolone to 17-hydroxypregnenolone
progesterone to 17-hydroxyprogesterone?
17a-hydroxylase
what enzyme is responsible for catalyzing the reaction
deoxycortisone to cortisone?
11B-hydroxylase
what types of receptors are glucocorticoid and mineralocorticoid?
nuclear hormone receptors
cortisol binds to what receptors?
glucocorticoid
mineralocorticoid
does cortisone bind to mineralocorticoid receptors?
no
where is cortisone converted to cortisol? what is the enzyme?
liver
11B-HSD1
which enzyme is responsible for converting cortisol back to cortisone?
11B-HSD2
what type of drug is fludrocortisone? what effects does it have?
mineralocorticoid
heavy salt retaining
anti-inflammatory
what enzyme is important in converting prodrugs into their active forms?
11B-HSD1
what are the causes of primary adrenal insufficiency (addison’s disease)?
autoimmune
TB
what are the results of primary adrenal insufficiency (addison’s disease)?
deficiency in cortisol, aldosterone, androgens
hypotension from unresponsiveness of vascular smooth muscle to catecholamines
primary adrenal insufficiency (addison’s disease) is treated with what agents?
cortisol
fludrocortisone
secondary adrenal insufficiency are due to what causes?
pituitary - 1) decrease in ACTH causing increase in CRH, 2) decrease in cortisol
hypothalamic - 1) decrease in CRH causes increase in ACTH, 2) decrease in cortisol
secondary adrenal insufficiency (addison’s disease) is treated with what agent?
cortisol (fludrocortisone NOT needed)