Autonomic pharmacology III Flashcards
what is the mechanism of atropine?
competes with Ach at M receptors (does not discriminate between M1, M2, M3)
what are the pharmacological effects of atropine?
- decreased secretions
- mydrisasis and cycloplegia
- hyperthermia
- tachycardia
- sedation
- urinary retention and constipation
- behavioral excitation and hallucination
what are the clinical uses for atropine?
- antispasmotic
- antisecretory
- management of AchE inhibitor overdose
- antidiarrheal
- opthamology
- prevent vagal reaction in some procedures
what are the properties of ipratropium?
- nonselective muscarinic antagonis
- mainly acts on M3 in bronchial SMCs and glands when inhaled
- no CNS absorption
what are the pharmacological effects of ipratropium in the lungs?
- decreases bronchoconstriction
2. decreases bronchial secretions
what are the clinical uses of ipratropium?
- COPD
2. asthma
what are the properties of benztropine?
- CNS absorption
- acts on muscarinic receptors in the brain
- PNS effector sites
what are the pharmacological effects of benztropine?
- reestablishment of dopaminergic-cholinergic balance in patients with Parkinson’s Disease
- decreased GI/GU secretions, decreased motility
- increased HR
what are the clinical uses for benztropine?
Parkinson’s Disease
what are the effects of the ganglion blocking agents?
- reduce predominant autonomic tone
2. prevent baroreceptor reflex changes in HR
what determines whether or not a neuromuscular blocking drug is depolarizing or non-depolarizing?
whether they are a real blocker of the channel or actually an agonist (activator) of the channel
what is the mechanism for neuromuscular blocking drugs?
compete for receptor and interfere with transmission at the neuromuscular endplate
what are the clinical uses for neuromuscular blocking drugs?
- facilitate tracheal intubation
2. optimize surgical conditions while ensuring adequate ventilation
what is the prototypical non-depolarizing neuromuscular blocking drug?
tubocurarine
what is the mechanism for non-depolarizing neuromuscular blocking drugs?
- prevent opening of channel when bound to receptor
- small dose - compete with Ach
- large dose - enter pores
- can also block pre-junctional Na channel to decrease Ach release
what is the prototypical depolarizing neuromuscular blocking drug?
succinylcholine
what is the mechanism for depolarizing neuromuscular blocking drugs?
- phase I - bind to Nm, persistent depolarization, paralysis, augmented by AchE inhibitors
- phase II - end plate desensitization
what are the clinical uses for depolarizing neuromuscular blocking drugs?
- decrease neuromuscular transmission during anesthesia
- intubation
- ventilation control
- anticonvulsive
what are the side effects of depolarizing neuromuscular blocking drugs?
- hypotension (histamine release)
- high dose - ganglion blockade - severe hypotension
- hyperkalemia
- increased intraocular pressure
- increased gastric pressure
- muscle pain
what is the rate limiting step of catecholamine synthesis?
tyrosine hydroxylase
which step of catecholamine synthesis occurs only in the medulla?
NE to EPI via phenylethanolamine-N-methyltransferase
what is the function of metryrosine?
tyrosine hydroxylase inhibitor
what is the function of reserpine?
inhibitor of VMAT
what is the effect of reserpine on BP?
decrease (decreases secretion of NE)
what is the function of bretylium?
VAMP inhibitor - prevention of exocytosis
what are the three fates of catecholamines following exocytosis?
- diffusion - metabolized by catechol-O-methyltransferase
- autoreceptor - decreased release
- reuptake via NET - repackaged and metabolized by MAO
what is the function of MAO inhibitors?
increases NE