Antihyperlipidemics Flashcards
what is the lowest density lipoprotein?
chylomicron
what are the roles of the apolipoproteins?
- cofactors
- ligands for receptors
- structural stability
what is the role of NPC1L1?
cholesterol uptake
which drug inhibits the NPC1L1 enzyme?
ezetimibe
what is the role of acetyl CoA cholesterol acyltransferase?
converts cholesterol to cholesterol ester
what is the role of diglyceride acyltransferase?
converts monoglycerides to TGs
where are chylomicrons associated with the B28 apoprotein?
intestine
where do chylomicrons associate with apoC2 and apo3?
lymphatic system
where are the chylomicrons broken down to TGs by lipoprotein lipase?
capillaries (via apoC2)
what is the importance of apoE?
allows chylomicron remnants to be taken back up by liver
what is the importance of apoB100 for VLDL particles?
ligand for LDL receptors (important for clearance of cholesterol from circulatory system)
what is reverse cholesterol transport?
- HDL accepts excess cholesterol from peripheral tissues
- HDL is transported to liver where it binds SRB1 via apoA1 and cholesterol esters are selectively delivered to hepatocytes
apoA1 is associated with which lipoproteins? what is its function?
- HDL, chylomicrons
2. structural for HDL, activates LCAT, SRB1 ligand
apoA2 is associated with which lipoproteins? what is its function?
- HDL, chylomicrons
2. structural for HDL
apoB48 is associated with which lipoproteins? what is its function?
- chylomicrons, remnants
2. structural