Thyroid

Question 1

Synthesis and Transport of Thyroid Hormones:
A. Peripheral Conversion of T4 to T3 B. Iodine organification C. Iodide conversion to iodine D. Coupling E. Proteolysis and Release

Answer 1

C B D E A

Question 2

Converts Iodide to Iodine

Answer 2

Thyroid Peroxidase

Question 3

Autoimmune disorder where B lymphocytes produce an antibody activating TSH receptors causing thyrotoxicosis

Answer 3

Graves Disease

Question 4

More potent peripheral thyroid hormone

Answer 4

T3

Question 5

Triad of Graves Disease

Answer 5

Exophthalmos, Pretibial Myxedema, Goiter

Question 6

T3 analog

Answer 6

Liothyronine

Question 7

T4 analog

Answer 7

Levothyroxine

Question 8

Myxedema Coma DOC

Answer 8

IV Levothyroxine

Question 9

Medical emergency representing end-state hypothroidism

Answer 9

Myxedema Coma

Question 10

Dosage of Levothyroxine Loading in Myxedema Coma

Answer 10

300 - 400 mcg

Question 11

Dosage of Levothyroxine Maintenance in Myxedema Coma

Answer 11

50 - 100 mcg daily

Question 12

Pregnancy hyperthyroidism DOC

Answer 12

Propylthiouracil

Question 13

Thioamides

Answer 13

Propylthiouracil and Methimazole

Question 14

Most potent thioamide

Answer 14

Propylthiouracil

Question 15

Side effect of thioamides

Answer 15

Hypothyroidism

Agranulocytosis

Question 16

Teratogenic effect of Methimazole

Answer 16

Aplasia cutis congenita

Question 17

Non-pregnant hyperthyroidism DOC

Answer 17

Methimazole

Question 18

Propylthiouracil MOA

Answer 18

Inhibits thyroid peroxidase, Inhibits iodine organification and Inhibits peripheral conversion of T4 to T3

Question 19

Methimazole MOA

Answer 19

Inhibits thyroid peroxidase and inhibits iodine organification

Question 20

Acute severe neutropenia caused by thioamides

Answer 20

Agranulocytosis

Question 21

Agranulocytosis DOC

Answer 21

G-CSF

Question 22

Definitive treatment for hyperthyrodism

Answer 22

Radioactive Iodine (I 131)

Question 23

Radioactive Iodine MOA

Answer 23

beta rays emitted destroy thyroid parenchyma

Question 24

Side effect of Radioactive MOA

Answer 24

Permanent Hypothyroidism

Question 25

Lugol’s Solution

Answer 25

Potassium Iodide

Question 26

Iodine + Potassium Iodine

Answer 26

Lugol’s Solution (Potassium Iodide)

Question 27

Potassium Iodide MOA

Answer 27

Inhibit iodine organification and release of T3 and T4

Decreased gland vascularity and size

Question 28

Use of Potassium Iodide

Answer 28

Pre-thyroidectomy drug to reduce bleeding risk
Radiation prophylaxis
Thyroid storm

Question 29

Effect of prenatal exposure to potassium iodide

Answer 29

Fetal goiter

Question 30

Hyperthyroidism after intake of iodine

Answer 30

Jod-Basedow Phenomenon

Question 31

Hypothyroidism after intake of iodine

Answer 31

Wolf-Chaikoff Phenomenon

Question 32

Beta-blocker inhibiting peripheral conversion of T4 to T3

Answer 32

Propranolol, Atenolol, Metoprolol, Esmolol

Question 33

Beta-blocker used to treat thyrotoxicosis-induced arryhthmia

Answer 33

Esmolol

Question 34

T/F: Propranolol alters thyroid hormone levels

Answer 34

False

Question 35

Drugs that cause peripheral conversion of T4 to T3

Answer 35

PTU, Propranolol, Hydrocortisone

Question 36

Sudden and life-threatening acute exacerbation of thyrotoxic symptoms with granulocyte count of <500 cells/mm3

Answer 36

Thyroid Storm

Question 37

Thyroid Storm treatment

Answer 37

PTU, Iodide, Propranolol, Hydrocortisone

Question 38

Drug-induced hyperthyroidism

Answer 38

Clofibrate, Amiodarone, Methadone

Question 39

Amiodarone-induced hypothyroidism DOC

Answer 39

Levothyroxine

Question 40

Amiodarone-induced hyperthyroidism DOC

Answer 40

Thioamides/Hydrocortisone