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Pharmacology > Anti TB Drugs > Flashcards

Anti TB Drugs Flashcards

1
Q

Bactericidal Anti-mycobacterial

A

HRZS

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2
Q

Bacteriostatic Anti-mycobacterial

A

EZ

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3
Q

Inhibits mycolic acid synthesis

A

Isoniazid

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4
Q

Side effect of Isoniazid

A

Neurotoxic and Hepatotoxic

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5
Q

Neurotoxicity prevention for isoniazid

A

Pyridoxine

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6
Q

Rifamycin

A

Rifampicin, Rifabutine, Rifapentine

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7
Q

RNA polymerase inhibitor

A

Rifampicin

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8
Q

Red orange urine

A

Rifampicin

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9
Q

Anti-mycobacterial that rapidly develop resistance if used alone

A

Rifampicin

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10
Q

Indications of Rifampicin

A

TB, Leprosy
Drug resistant infections
Meningococcal, Staphylococcal

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11
Q

Inhibits arabinosyl transferase involved in arabinogalactan synthesis in cell wall

A

Ethambutol

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12
Q

Red-green color blindness

A

Ethambutol

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13
Q

Retrobulbar neuritis

A

Ethambutol

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14
Q

Bactericidal only on actively dividing mycobacteria

A

Pyrazinamide

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15
Q

Most hepatotoxic Anti-TB drug

A

Pyrazinamide

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16
Q

Sterilizing Anti-TB drug

A

Pyrazinamide

17
Q

Anti-TB drug causing asymptomatic hyperuricemia

A

Pyrazinamide

18
Q

Hepatotoxic anti-TB drugs

A

Isoniazid < Rifampicin < Pyrazinamide

19
Q

Antimycobacterial Aminoglycoside

A

Streptomycin

20
Q

Streptomycin-resistant or MDR-TB

A

Amikacin

21
Q

First-line-drug-resistant TB

A

Ciprofloxacin, Ofloxacin

22
Q

Bacteriostatic anti-leprosy drug

A

Dapsone, Acedapsone

23
Q

Bactericidal anti-leprosy drug

A

Clofazimine

24
Q

Anti-mycobacterial drug inhibiting folic acid synthesis

A

Dapsone

25
Q

Side effect of Dapsone

A

Methemoglobinemia

26
Q

Most active drug against Mycobacterium leprae

A

Dapsone

27
Q

Lepromatous Leprosy DOC

A

Dapsone + Cofazimine + Rifampicin

28
Q

Tuberculous Leprosy DOC

A

Dapsone + Rifampicin

29
Q

Anti-leprosy drug causing skin discoloration

A

Clofazimine

30
Q

Clofazimine MOA

A

Binds to guanine bases in bacterial DNA

31
Q

Mycobacterium avium prophylaxis CD4 < 50

A

Clarithromycin or Azithromycin

with or without Rifabutin

32
Q

Treatment of Atypical Mycobacterial infection

A

Azithromycin or Clarithromycin plus

Rifabutin AND Ethambutol

Pharmacology (31 decks)

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