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Pharmacology > Bone and Mineral Hemostasis > Flashcards

Bone and Mineral Hemostasis Flashcards

1
Q

Regulates Parathyroid Hormone

A

Ionized Calcium

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2
Q

PTH on intestine

A

Increase Vit D metabolite

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3
Q

PTH on kidney

A

Decrease calcium excretion

Increase phosphate excretion

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4
Q

High dose PTH on bone

A

Increase calcium and phospate reabsorption

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5
Q

Low intermittent dose PTH on bone

A

Bone formation

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6
Q

Vit D metabolite on intestine

A

Increase calcium absorption

Increase phosphate absorption

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7
Q

Vit D metabolite on kidney

A

Increase urinary calcium

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8
Q

Direct effect of Vit D metabolite on bone

A

Increase calcium reabsorption

Increase phosphate reabsorption

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9
Q

Indirect effect of Vit D metabolite on bone

A

Mineralization

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10
Q

Net serum effect of PTH

A

Increase Calcium

Decrease Phosphate

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11
Q

Net serum effect of Vit D metabolite

A

Increase Calcium

Increase Phosphate

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12
Q

Recombinant PTH

A

Teriparatide

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13
Q

PTH stimulation of osteoblast cause formation of what gland that stimulates osteoclast

A

RANK Ligand (RANKL)

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14
Q

Osteoclast and Osteoblast activity

A

Bone turnover

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15
Q

Inactive Vit D Metabolite

A

Ergocalciferol, Cholecalciferol

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16
Q

Active form of Vit D

A

1, 25 - Dihydroxycholecalciferol

17
Q

Active Vit D Metabolite

A

Calcitriol, Doxecalciferol, Paricalcitol, Calcipotriene

18
Q

Vitamin D Deficiency DOC

A

Inactive Vit D Metabolite

19
Q

DOC for Hypoparathyroidism and Hyperparathyroidism in CKD and Liver disease

A

Active Vit D Metabolite

20
Q

Released by the Parafollicular C cells in the thyroid gland

A

Calcitonin

21
Q

Calcitonin MOA

A

Inhibit renal reabsorption and bone resorption

Decrease serum phosphate and calcium

22
Q

Calcitonin SimD

A

Salcatonin

23
Q

Tumor marker for Medullary thyroid Ca

A

Salcatonin

24
Q

Route of administration of Calcitonin

A

Nasal spray

25
Q

Indications for Calcitonin and Bisphosphonate

A

Paget’s disease of the bone
Hypercalcemia
Osteoporosis

26
Q

Bisphosphonate

A

Alendronate (-dronate, -dronic)

27
Q

Bisphosphonate MOA

A

Suppress activity of osteoclast inhibit bone resorption

28
Q

Side effect of Bisphosphonate

A

Esophagitis (100%)
Jaw osteonecrosis
Renal impairment

29
Q

Phosphate binding resin

A

Sevelamer

30
Q

Sevelamer MOA

A

binds with dietary phosphate and prevent its absoprtion

reduce uric acid level

31
Q

Vit D Intoxication DOC

A

Phosphate binding resin

Pharmacology (31 decks)

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