Antibiotics - Cell Wall Synthesis Inhibitors

Question 1

i am FURious and I will KILL you! ginamit pa nAMIN ang VAN to buy GRAMs of FLOUR and a PEN from the METRO!

Answer 1

Bactericidal Antibiotics - Nitrofurantoin, Aminoglycosides, Vancomycin, Streptogrammin, Fluoroquinolones, Penicillin, Metronidazole

Question 2

ERYs and CLIff are ecSTATIC! they went to SMX to TRIM LINEz in the CHLORinated TETRApack.

Answer 2

Bacteriostatic Antibiotics - Erythromycin, Clindamycin, Sulfamethoxazole, Trimethoprim, Linezolid, Chloramphenicol, Tetracycline

Question 3

Bacterial Cell Wall Synthesis Inhibitors

Answer 3

Penicillins, Cephalosporins, Carbapenems, Aztreonam

Question 4

Beta Lactamase Inhibitors

Answer 4

Clavulanic Acid, Sulbactam, Tazobactam

Question 5

Inhibits D-Ala-D-Ala terminus of nascent peptidoglycan

Answer 5

Vancomycin, Teicoplanin (SimD)

Question 6

Bacterial Cell Wall Synthesis Inhibitor MOA

Answer 6

Beta Lactam enters cytoplasm via PORINS and binds to penicillin-binding-proteins (PBP) inhibiting transpeptidation at the cell wall

Question 7

Enzymatic hydrolysis of the beta-lactam ring

Answer 7

Beta Lactamase

Question 8

Mechanism of Penicillin resistance

Answer 8

Beta Lactamase
PBP structural change
Porin structure change

Question 9

Penicillin V route of administration

Answer 9

Oral

Question 10

Penicillin G route of administration

Answer 10

Injection

Question 11

Narrow spectrum Penicillin

Answer 11

Pen V, Pen G

Question 12

Streptococcal, Pneumococcal, Meningococcal and Syphilis DOC

Answer 12

Pen V, Pen G

Question 13

Very Narrow spectrum Penicillin

Answer 13

Methicillin (Nafcillin, Oxacillin, Cloxacillin)

Question 14

Staphylococcal DOC

Answer 14

Methicillin

Question 15

Beta lactamase resistant Penicillin

Answer 15

Methicillin

Question 16

Penicillin causing interstitial nephritis

Answer 16

Methicillin

Question 17

Penicillin causing neutropenia

Answer 17

Nafcillin

Question 18

Extended spectrum Penicillin

Answer 18

Amoxicillin, Ampicillin

Question 19

Hemophilus, Enterococci, Listeria, Proteus, Salmonella, E. Coli DOC

Answer 19

Amoxicillin, Ampicillin

Question 20

Anti-pseudomonal Penicillin

Answer 20

Ticarcillin, Carbenicillin, Piperacillin

Question 21

Bacterial Cell wall synthesis inhibitor with greatest bone and soft tissue penetration

Answer 21

Cephalosporin

Question 22

First Generation Cephalosporin

Answer 22

(-FAD, -FAZ-, -PH-)

Question 23

Proteus, E. Coli, Klebsiella

Answer 23

First Generation Cephalosporin

Question 24

Increases nephrotoxicity with aminoglycosides

Answer 24

First and Second Generation Cephalosporins

Question 25

Cross-allergenicity with Penicillin

Answer 25

Cephalosporins

Question 26

Second Generation Cephalosporin

Answer 26

(-FAM, -FOX, -FOR, -FUR, -TEA, -LOR, -AZOLE, -PRO, -FON)

Question 27

Hemophilus, Enterobacter, Neisseria, Proteus, E. Coli, Klebsiella, Serratia

Answer 27

Second Generation Cephalosporin

Question 28

HEN PEcKS

Answer 28

Second Generation Cephalosporin

Question 29

FIRST PEcK

Answer 29

First Generation Cephalosporin

Question 30

FAM FOX FOR FUR TEA LOR AZOLE PRO FON

Answer 30

Second Generation Cephalosporin

Question 31

FEnge PO ng PERA to FIX my FT3 and TAX

Answer 31

Third Generation Cephalosporin

Question 32

Third Generation Cephalosporin

Answer 32

FE, PO, PERA, FIX, TAX, FT

Question 33

Anti-pseudomonal Cephalosporin

Answer 33

Ceftazidime, Cefepime, Cefoperazone

Question 34

Fourth Generation Cephalosporin

Answer 34

Cefepime

Question 35

Synergistic with Aminoglycosides

Answer 35

Third Generation Cephalosporin

Question 36

Beta lactamase resistant Cephalosporin

Answer 36

Cefepime

Question 37

Gram + >> Gram -

Answer 37

Third Generation Cephalosporin

Question 38

Wide Gram + and Gram - coverage

Answer 38

Fourth Generation Cephalosporin, Carbapenems

Question 39

Carbapenems

Answer 39

Imipinem-Cilastatin, Ertepenem, Meropenem

Question 40

Side effect of Carbapenems

Answer 40

CNS toxicity

Question 41

Reserved for life-threatening infections

Answer 41

Carbapenems

Question 42

Prolongs action of Imipinem

Answer 42

Cilastatin (inhibit renal metabolism)

Question 43

Monobactam

Answer 43

Aztreonam

Question 44

Beta lactamase inhibitor resistant Gram -, Pseudomonas, Klebsiella, Serratia

Answer 44

Aztreonam

Question 45

Aztreonam features

Answer 45

Does not cross-react with Penicillin Resistant to Beta Lactamase No Gram + or Anaerobe activity

Question 46

Beta-lactamase producing Hemophilus, E. coli, Neisseria, Streptococcus

Answer 46

Clavulanic Acid

Question 47

Vancomycin Class

Answer 47

Glycopeptide

Question 48

MRSA and Pseudomembranous colitis DOC

Answer 48

Vancomycin

Question 49

Syndrome caused by Vancomycin

Answer 49

Red Man Syndrome

Question 50

Treatment of Vancomycin side effect

Answer 50

Antihistamines

Question 51

Bacitracin MOA

Answer 51

Topical drug that inhibit cell wall synthesis of Gram + bacteria only

Question 52

Antimetabolite that blocks D-Ala incorporation into the pentapeptide side chain of peptidoglycan

Answer 52

Cycloserine

Question 53

Second line drug for Drug Resistant TB

Answer 53

Cycloserine

Question 54

Side effect of Cycloserine

Answer 54

Neurotoxicity

Question 55

More bacteria killed as plasma concentration exceed MIC

Answer 55

Concentration-Dependent Antibacterial Action

Question 56

Efficacy is dependent on time above MIC

Answer 56

Time-Dependent Antibacterial Action

Question 57

Concentration-Dependent or Time-Dependent: | Penicillin

Answer 57

Time-Dependent

Question 58

Concentration-Dependent or Time-Dependent: | Aminoglycoside

Answer 58

Concentration-Dependent

Question 59

Concentration-Dependent or Time-Dependent: | Cephalosporin

Answer 59

Time-Dependent

Question 60

Antibacterial effect continues despite absence of measurable plasma level

Answer 60

Post-antibiotic Effect

Question 61

Drugs that exhibit post-antibiotic effect

Answer 61

Aminoglycosides and Fluoroquinolones