Antibiotics - Cell Wall Synthesis Inhibitors Flashcards

1
Q

i am FURious and I will KILL you! ginamit pa nAMIN ang VAN to buy GRAMs of FLOUR and a PEN from the METRO!

A

Bactericidal Antibiotics - Nitrofurantoin, Aminoglycosides, Vancomycin, Streptogrammin, Fluoroquinolones, Penicillin, Metronidazole

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2
Q

ERYs and CLIff are ecSTATIC! they went to SMX to TRIM LINEz in the CHLORinated TETRApack.

A

Bacteriostatic Antibiotics - Erythromycin, Clindamycin, Sulfamethoxazole, Trimethoprim, Linezolid, Chloramphenicol, Tetracycline

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3
Q

Bacterial Cell Wall Synthesis Inhibitors

A

Penicillins, Cephalosporins, Carbapenems, Aztreonam

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4
Q

Beta Lactamase Inhibitors

A

Clavulanic Acid, Sulbactam, Tazobactam

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5
Q

Inhibits D-Ala-D-Ala terminus of nascent peptidoglycan

A

Vancomycin, Teicoplanin (SimD)

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6
Q

Bacterial Cell Wall Synthesis Inhibitor MOA

A

Beta Lactam enters cytoplasm via PORINS and binds to penicillin-binding-proteins (PBP) inhibiting transpeptidation at the cell wall

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7
Q

Enzymatic hydrolysis of the beta-lactam ring

A

Beta Lactamase

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8
Q

Mechanism of Penicillin resistance

A

Beta Lactamase
PBP structural change
Porin structure change

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9
Q

Penicillin V route of administration

A

Oral

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10
Q

Penicillin G route of administration

A

Injection

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11
Q

Narrow spectrum Penicillin

A

Pen V, Pen G

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12
Q

Streptococcal, Pneumococcal, Meningococcal and Syphilis DOC

A

Pen V, Pen G

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13
Q

Very Narrow spectrum Penicillin

A

Methicillin (Nafcillin, Oxacillin, Cloxacillin)

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14
Q

Staphylococcal DOC

A

Methicillin

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15
Q

Beta lactamase resistant Penicillin

A

Methicillin

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16
Q

Penicillin causing interstitial nephritis

A

Methicillin

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17
Q

Penicillin causing neutropenia

A

Nafcillin

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18
Q

Extended spectrum Penicillin

A

Amoxicillin, Ampicillin

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19
Q

Hemophilus, Enterococci, Listeria, Proteus, Salmonella, E. Coli DOC

A

Amoxicillin, Ampicillin

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20
Q

Anti-pseudomonal Penicillin

A

Ticarcillin, Carbenicillin, Piperacillin

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21
Q

Bacterial Cell wall synthesis inhibitor with greatest bone and soft tissue penetration

A

Cephalosporin

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22
Q

First Generation Cephalosporin

A

(-FAD, -FAZ-, -PH-)

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23
Q

Proteus, E. Coli, Klebsiella

A

First Generation Cephalosporin

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24
Q

Increases nephrotoxicity with aminoglycosides

A

First and Second Generation Cephalosporins

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25
Q

Cross-allergenicity with Penicillin

A

Cephalosporins

26
Q

Second Generation Cephalosporin

A

(-FAM, -FOX, -FOR, -FUR, -TEA, -LOR, -AZOLE, -PRO, -FON)

27
Q

Hemophilus, Enterobacter, Neisseria, Proteus, E. Coli, Klebsiella, Serratia

A

Second Generation Cephalosporin

28
Q

HEN PEcKS

A

Second Generation Cephalosporin

29
Q

FIRST PEcK

A

First Generation Cephalosporin

30
Q

FAM FOX FOR FUR TEA LOR AZOLE PRO FON

A

Second Generation Cephalosporin

31
Q

FEnge PO ng PERA to FIX my FT3 and TAX

A

Third Generation Cephalosporin

32
Q

Third Generation Cephalosporin

A

FE, PO, PERA, FIX, TAX, FT

33
Q

Anti-pseudomonal Cephalosporin

A

Ceftazidime, Cefepime, Cefoperazone

34
Q

Fourth Generation Cephalosporin

A

Cefepime

35
Q

Synergistic with Aminoglycosides

A

Third Generation Cephalosporin

36
Q

Beta lactamase resistant Cephalosporin

A

Cefepime

37
Q

Gram +&raquo_space; Gram -

A

Third Generation Cephalosporin

38
Q

Wide Gram + and Gram - coverage

A

Fourth Generation Cephalosporin, Carbapenems

39
Q

Carbapenems

A

Imipinem-Cilastatin, Ertepenem, Meropenem

40
Q

Side effect of Carbapenems

A

CNS toxicity

41
Q

Reserved for life-threatening infections

A

Carbapenems

42
Q

Prolongs action of Imipinem

A

Cilastatin (inhibit renal metabolism)

43
Q

Monobactam

A

Aztreonam

44
Q

Beta lactamase inhibitor resistant Gram -, Pseudomonas, Klebsiella, Serratia

A

Aztreonam

45
Q

Aztreonam features

A

Does not cross-react with Penicillin
Resistant to Beta Lactamase
No Gram + or Anaerobe activity

46
Q

Beta-lactamase producing Hemophilus, E. coli, Neisseria, Streptococcus

A

Clavulanic Acid

47
Q

Vancomycin Class

A

Glycopeptide

48
Q

MRSA and Pseudomembranous colitis DOC

A

Vancomycin

49
Q

Syndrome caused by Vancomycin

A

Red Man Syndrome

50
Q

Treatment of Vancomycin side effect

A

Antihistamines

51
Q

Bacitracin MOA

A

Topical drug that inhibit cell wall synthesis of Gram + bacteria only

52
Q

Antimetabolite that blocks D-Ala incorporation into the pentapeptide side chain of peptidoglycan

A

Cycloserine

53
Q

Second line drug for Drug Resistant TB

A

Cycloserine

54
Q

Side effect of Cycloserine

A

Neurotoxicity

55
Q

More bacteria killed as plasma concentration exceed MIC

A

Concentration-Dependent Antibacterial Action

56
Q

Efficacy is dependent on time above MIC

A

Time-Dependent Antibacterial Action

57
Q

Concentration-Dependent or Time-Dependent:

Penicillin

A

Time-Dependent

58
Q

Concentration-Dependent or Time-Dependent:

Aminoglycoside

A

Concentration-Dependent

59
Q

Concentration-Dependent or Time-Dependent:

Cephalosporin

A

Time-Dependent

60
Q

Antibacterial effect continues despite absence of measurable plasma level

A

Post-antibiotic Effect

61
Q

Drugs that exhibit post-antibiotic effect

A

Aminoglycosides and Fluoroquinolones