Antibiotics - Cell Wall Synthesis Inhibitors Flashcards
i am FURious and I will KILL you! ginamit pa nAMIN ang VAN to buy GRAMs of FLOUR and a PEN from the METRO!
Bactericidal Antibiotics - Nitrofurantoin, Aminoglycosides, Vancomycin, Streptogrammin, Fluoroquinolones, Penicillin, Metronidazole
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Bacteriostatic Antibiotics - Erythromycin, Clindamycin, Sulfamethoxazole, Trimethoprim, Linezolid, Chloramphenicol, Tetracycline
Bacterial Cell Wall Synthesis Inhibitors
Penicillins, Cephalosporins, Carbapenems, Aztreonam
Beta Lactamase Inhibitors
Clavulanic Acid, Sulbactam, Tazobactam
Inhibits D-Ala-D-Ala terminus of nascent peptidoglycan
Vancomycin, Teicoplanin (SimD)
Bacterial Cell Wall Synthesis Inhibitor MOA
Beta Lactam enters cytoplasm via PORINS and binds to penicillin-binding-proteins (PBP) inhibiting transpeptidation at the cell wall
Enzymatic hydrolysis of the beta-lactam ring
Beta Lactamase
Mechanism of Penicillin resistance
Beta Lactamase
PBP structural change
Porin structure change
Penicillin V route of administration
Oral
Penicillin G route of administration
Injection
Narrow spectrum Penicillin
Pen V, Pen G
Streptococcal, Pneumococcal, Meningococcal and Syphilis DOC
Pen V, Pen G
Very Narrow spectrum Penicillin
Methicillin (Nafcillin, Oxacillin, Cloxacillin)
Staphylococcal DOC
Methicillin
Beta lactamase resistant Penicillin
Methicillin
Penicillin causing interstitial nephritis
Methicillin
Penicillin causing neutropenia
Nafcillin
Extended spectrum Penicillin
Amoxicillin, Ampicillin
Hemophilus, Enterococci, Listeria, Proteus, Salmonella, E. Coli DOC
Amoxicillin, Ampicillin
Anti-pseudomonal Penicillin
Ticarcillin, Carbenicillin, Piperacillin
Bacterial Cell wall synthesis inhibitor with greatest bone and soft tissue penetration
Cephalosporin
First Generation Cephalosporin
(-FAD, -FAZ-, -PH-)
Proteus, E. Coli, Klebsiella
First Generation Cephalosporin
Increases nephrotoxicity with aminoglycosides
First and Second Generation Cephalosporins