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Chemotherapeutics Flashcards

0
Q

Cell cycle specific drug action

A

Tumor stem cells traversing cell cycle only

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1
Q

Cell cycle non-specific drug action

A

Tumor stem cells traversing cell cycle and at resting phase (G0)

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2
Q

G0 phase chemotherapeutic agents

A

Alkylating agents, Antibiotics, Antitumor, Nitrosurea (Lomustine, Carmustine, Cisplatin)

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3
Q

M phase chemotherapeutic agents

A

Vincristine
Vinblastine
Paclitaxel

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4
Q

G2 phase chemotherapeutic agents

A

Bleomycin

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5
Q

S phase chemotherapeutic agents

A

6-thioguanine, 6-mercaptopurine
Cytarabine, Hydroxyurea
Etoposide, Methotrexate

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6
Q

All trans retinoic acid

A

Acute promyelogenous leukemia

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7
Q

Acute Lymphocytic Leukemia

A

Methotrexate, Vincristine, ASPARAGINASE, Prednisone

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8
Q

Acute Myelogenous Leukemia

A

Cytarabine Rubicin

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9
Q

Breast Carcinoma

A

Cytotoxic agent, Tamoxifen, Anastrazole, Trastuzamab

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10
Q

Chronic Myelogenous Leukemia

A

Imatinib, Busulfan, Interferon

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11
Q

Colon Carcinoma

A

Fluorouracil, Oxaliplatin, Leucovorin

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12
Q

Hodgkin’s Lymphoma

A

ABVD Regimen: Doxorubicin, Bleomycin, Vincristine, Dacarbazine + Prednisone

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13
Q

Non-Hodgkin’s Lymphoma

A

CHOP Regimen: Cyclophosphamide, Doxorubicin, Vincristine, Prednisone + Rituximab

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14
Q

Ovarian Carcinoma

A

Carboplatin + Paclitaxel

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15
Q

Pancreatic Carcinoma

A

Gemticabine + Erlotinib

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16
Q

Prostate Carcinoma

A

Ganirelix or

Leuprolide + Flutamide

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17
Q

Lung Carcinoma

A

Paclitaxel, Bevacizumab, Carboplatin

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18
Q

Testicular Carcinoma

A

PEB Regimen: Bleomycin, Etoposide, Cisplatin (Platinol)

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19
Q

Cyclophosphamide rescue therapy

A

MESNA

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20
Q

Methotrexate rescue therapy

A

Leucovorin / Folinic acid

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21
Q

Doxorubicin rescue therapy

A

Dexrazoxane

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22
Q

Cisplatin rescue therapy

A

Amifostine

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23
Q

Side effect of cyclophosphamide

A

Hemorrhagic cystitis

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24
Q

Side effect of cisplatin and carboplatin

A

Nephrotoxicity and acoustic nerve damage

25
Q

Decreases nephrotoxicity with cisplatin and carboplatin

26
Q

Leukemogenic alkylating agent

A

Procarbazine

27
Q

Side effect of dacarbazine

A

Phototoxicity

28
Q

Non-leukemogenic version of procarbazine

A

Dacarbazine

29
Q

Bone-marrow sparing chemotherapeutic drug

30
Q

Highly lipophilic chemotherapeutic drug targeting brain tumors

A

Carmustine

31
Q

Thymine-less cell death by inhibiting thymidylate synthase

A

5 Fluorouracil

32
Q

Chemotherapeutic drug activated by HGPRT

A

6 Mercaptopurine

33
Q

Drugs that inhibit 6 Mercaptopurine activity

A

Allopurinol and Febuxostat

34
Q

Inhibits ribonucleotide reductase inhibiting DNA synthesis and repair

A

Cytarabine

35
Q

CML in blast crisis - chloroma

A

Cytarabine

36
Q

Vinca alkaloid causing paralytic ileus

A

Vincristine

37
Q

Prevente microtubule disassembly

A

Paclitaxel

38
Q

Prevents microtubule assembly

A

Vinca alkaloids

39
Q

Podophyllotoxin

40
Q

Inhibits DNA topoisomerase II and mitochondrial ETC

41
Q

Topotecan MOA

A

Inhibits Topoisomerase I

42
Q

Metastatic colorectal cancer

A

Irinotecan

43
Q

Paclitaxel hematologic side effects

A

Neutropenia, Thrombocytopenia

44
Q

Camptothecin

45
Q

Antitumor causing irreversible dilated cardiomyopathy

A

Doxorubicin

46
Q

Anthracycline

A

Doxorubicin

47
Q

Bleomycin MOA

A

Generates free radicals

48
Q

Antibiotic Antitumor targets what malignancy

A

Wilm’s, Rhabdomyosarcoma (Actinomycin D)

49
Q

GIST anticancer drug

50
Q

Metastatic breast cancer

A

Trastuzamab

51
Q

Targets her2/neu receptors of breast cancer cells

A

Trastuzamab

52
Q

Block VEGF binding to VEGFR to lessen vascular permeability

High vascular flow and drug delivery

A

Bevacizumab

53
Q

Induces complement mediated tumor lysis, direct cytotoxicity and apoptosis

54
Q

Side effect of asparaginase

A

Acute pancreatitis

55
Q

Differentiation therapy

A

All trans retinoic acid

56
Q

Side effect of all trans retinoic acid therapy

A

Retinoic acid syndrome (tx dexamethasone)

57
Q

Glucocorticoid triggering apoptosis and act on non-dividing cancer cells

A

Prednisone

58
Q

Tamoxifen-resistant breast cancer

A

Anastrozole

59
Q

Decadron side effect

A

Puffy face

60
Q

Chemotherapeutic drugs that cause marked myelosuppression

A

5FU, 6MP, Methotrexate

61
Q

Vincristine side effect

A

Peripheral neuropathy

Pharmacology (31 decks)

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