Chemotherapeutics

Question 0

Cell cycle specific drug action

Answer 0

Tumor stem cells traversing cell cycle only

Question 1

Cell cycle non-specific drug action

Answer 1

Tumor stem cells traversing cell cycle and at resting phase (G0)

Question 2

G0 phase chemotherapeutic agents

Answer 2

Alkylating agents, Antibiotics, Antitumor, Nitrosurea (Lomustine, Carmustine, Cisplatin)

Question 3

M phase chemotherapeutic agents

Answer 3

Vincristine
Vinblastine
Paclitaxel

Question 4

G2 phase chemotherapeutic agents

Answer 4

Bleomycin

Question 5

S phase chemotherapeutic agents

Answer 5

6-thioguanine, 6-mercaptopurine
Cytarabine, Hydroxyurea
Etoposide, Methotrexate

Question 6

All trans retinoic acid

Answer 6

Acute promyelogenous leukemia

Question 7

Acute Lymphocytic Leukemia

Answer 7

Methotrexate, Vincristine, ASPARAGINASE, Prednisone

Question 8

Acute Myelogenous Leukemia

Answer 8

Cytarabine Rubicin

Question 9

Breast Carcinoma

Answer 9

Cytotoxic agent, Tamoxifen, Anastrazole, Trastuzamab

Question 10

Chronic Myelogenous Leukemia

Answer 10

Imatinib, Busulfan, Interferon

Question 11

Colon Carcinoma

Answer 11

Fluorouracil, Oxaliplatin, Leucovorin

Question 12

Hodgkin’s Lymphoma

Answer 12

ABVD Regimen: Doxorubicin, Bleomycin, Vincristine, Dacarbazine + Prednisone

Question 13

Non-Hodgkin’s Lymphoma

Answer 13

CHOP Regimen: Cyclophosphamide, Doxorubicin, Vincristine, Prednisone + Rituximab

Question 14

Ovarian Carcinoma

Answer 14

Carboplatin + Paclitaxel

Question 15

Pancreatic Carcinoma

Answer 15

Gemticabine + Erlotinib

Question 16

Prostate Carcinoma

Answer 16

Ganirelix or

Leuprolide + Flutamide

Question 17

Lung Carcinoma

Answer 17

Paclitaxel, Bevacizumab, Carboplatin

Question 18

Testicular Carcinoma

Answer 18

PEB Regimen: Bleomycin, Etoposide, Cisplatin (Platinol)

Question 19

Cyclophosphamide rescue therapy

Answer 19

MESNA

Question 20

Methotrexate rescue therapy

Answer 20

Leucovorin / Folinic acid

Question 21

Doxorubicin rescue therapy

Answer 21

Dexrazoxane

Question 22

Cisplatin rescue therapy

Answer 22

Amifostine

Question 23

Side effect of cyclophosphamide

Answer 23

Hemorrhagic cystitis

Question 24

Side effect of cisplatin and carboplatin

Answer 24

Nephrotoxicity and acoustic nerve damage

Question 25

Decreases nephrotoxicity with cisplatin and carboplatin

Answer 25

Mannitol

Question 26

Leukemogenic alkylating agent

Answer 26

Procarbazine

Question 27

Side effect of dacarbazine

Answer 27

Phototoxicity

Question 28

Non-leukemogenic version of procarbazine

Answer 28

Dacarbazine

Question 29

Bone-marrow sparing chemotherapeutic drug

Answer 29

Busulfan

Question 30

Highly lipophilic chemotherapeutic drug targeting brain tumors

Answer 30

Carmustine

Question 31

Thymine-less cell death by inhibiting thymidylate synthase

Answer 31

5 Fluorouracil

Question 32

Chemotherapeutic drug activated by HGPRT

Answer 32

6 Mercaptopurine

Question 33

Drugs that inhibit 6 Mercaptopurine activity

Answer 33

Allopurinol and Febuxostat

Question 34

Inhibits ribonucleotide reductase inhibiting DNA synthesis and repair

Answer 34

Cytarabine

Question 35

CML in blast crisis - chloroma

Answer 35

Cytarabine

Question 36

Vinca alkaloid causing paralytic ileus

Answer 36

Vincristine

Question 37

Prevente microtubule disassembly

Answer 37

Paclitaxel

Question 38

Prevents microtubule assembly

Answer 38

Vinca alkaloids

Question 39

Podophyllotoxin

Answer 39

Etoposide

Question 40

Inhibits DNA topoisomerase II and mitochondrial ETC

Answer 40

Etoposide

Question 41

Topotecan MOA

Answer 41

Inhibits Topoisomerase I

Question 42

Metastatic colorectal cancer

Answer 42

Irinotecan

Question 43

Paclitaxel hematologic side effects

Answer 43

Neutropenia, Thrombocytopenia

Question 44

Camptothecin

Answer 44

Topotecan

Question 45

Antitumor causing irreversible dilated cardiomyopathy

Answer 45

Doxorubicin

Question 46

Anthracycline

Answer 46

Doxorubicin

Question 47

Bleomycin MOA

Answer 47

Generates free radicals

Question 48

Antibiotic Antitumor targets what malignancy

Answer 48

Wilm's, Rhabdomyosarcoma (Actinomycin D)

Question 49

GIST anticancer drug

Answer 49

Imatinib

Question 50

Metastatic breast cancer

Answer 50

Trastuzamab

Question 51

Targets her2/neu receptors of breast cancer cells

Answer 51

Trastuzamab

Question 52

Block VEGF binding to VEGFR to lessen vascular permeability | High vascular flow and drug delivery

Answer 52

Bevacizumab

Question 53

Induces complement mediated tumor lysis, direct cytotoxicity and apoptosis

Answer 53

Rituximab

Question 54

Side effect of asparaginase

Answer 54

Acute pancreatitis

Question 55

Differentiation therapy

Answer 55

All trans retinoic acid

Question 56

Side effect of all trans retinoic acid therapy

Answer 56

Retinoic acid syndrome (tx dexamethasone)

Question 57

Glucocorticoid triggering apoptosis and act on non-dividing cancer cells

Answer 57

Prednisone

Question 58

Tamoxifen-resistant breast cancer

Answer 58

Anastrozole

Question 59

Decadron side effect

Answer 59

Puffy face

Question 60

Chemotherapeutic drugs that cause marked myelosuppression

Answer 60

5FU, 6MP, Methotrexate

Question 61

Vincristine side effect

Answer 61

Peripheral neuropathy