Chemotherapeutics Flashcards
Cell cycle specific drug action
Tumor stem cells traversing cell cycle only
Cell cycle non-specific drug action
Tumor stem cells traversing cell cycle and at resting phase (G0)
G0 phase chemotherapeutic agents
Alkylating agents, Antibiotics, Antitumor, Nitrosurea (Lomustine, Carmustine, Cisplatin)
M phase chemotherapeutic agents
Vincristine
Vinblastine
Paclitaxel
G2 phase chemotherapeutic agents
Bleomycin
S phase chemotherapeutic agents
6-thioguanine, 6-mercaptopurine
Cytarabine, Hydroxyurea
Etoposide, Methotrexate
All trans retinoic acid
Acute promyelogenous leukemia
Acute Lymphocytic Leukemia
Methotrexate, Vincristine, ASPARAGINASE, Prednisone
Acute Myelogenous Leukemia
Cytarabine Rubicin
Breast Carcinoma
Cytotoxic agent, Tamoxifen, Anastrazole, Trastuzamab
Chronic Myelogenous Leukemia
Imatinib, Busulfan, Interferon
Colon Carcinoma
Fluorouracil, Oxaliplatin, Leucovorin
Hodgkin’s Lymphoma
ABVD Regimen: Doxorubicin, Bleomycin, Vincristine, Dacarbazine + Prednisone
Non-Hodgkin’s Lymphoma
CHOP Regimen: Cyclophosphamide, Doxorubicin, Vincristine, Prednisone + Rituximab
Ovarian Carcinoma
Carboplatin + Paclitaxel
Pancreatic Carcinoma
Gemticabine + Erlotinib
Prostate Carcinoma
Ganirelix or
Leuprolide + Flutamide
Lung Carcinoma
Paclitaxel, Bevacizumab, Carboplatin
Testicular Carcinoma
PEB Regimen: Bleomycin, Etoposide, Cisplatin (Platinol)
Cyclophosphamide rescue therapy
MESNA
Methotrexate rescue therapy
Leucovorin / Folinic acid
Doxorubicin rescue therapy
Dexrazoxane
Cisplatin rescue therapy
Amifostine
Side effect of cyclophosphamide
Hemorrhagic cystitis
Side effect of cisplatin and carboplatin
Nephrotoxicity and acoustic nerve damage
Decreases nephrotoxicity with cisplatin and carboplatin
Mannitol
Leukemogenic alkylating agent
Procarbazine
Side effect of dacarbazine
Phototoxicity
Non-leukemogenic version of procarbazine
Dacarbazine
Bone-marrow sparing chemotherapeutic drug
Busulfan
Highly lipophilic chemotherapeutic drug targeting brain tumors
Carmustine
Thymine-less cell death by inhibiting thymidylate synthase
5 Fluorouracil
Chemotherapeutic drug activated by HGPRT
6 Mercaptopurine
Drugs that inhibit 6 Mercaptopurine activity
Allopurinol and Febuxostat
Inhibits ribonucleotide reductase inhibiting DNA synthesis and repair
Cytarabine
CML in blast crisis - chloroma
Cytarabine
Vinca alkaloid causing paralytic ileus
Vincristine
Prevente microtubule disassembly
Paclitaxel
Prevents microtubule assembly
Vinca alkaloids
Podophyllotoxin
Etoposide
Inhibits DNA topoisomerase II and mitochondrial ETC
Etoposide
Topotecan MOA
Inhibits Topoisomerase I
Metastatic colorectal cancer
Irinotecan
Paclitaxel hematologic side effects
Neutropenia, Thrombocytopenia
Camptothecin
Topotecan
Antitumor causing irreversible dilated cardiomyopathy
Doxorubicin
Anthracycline
Doxorubicin
Bleomycin MOA
Generates free radicals
Antibiotic Antitumor targets what malignancy
Wilm’s, Rhabdomyosarcoma (Actinomycin D)
GIST anticancer drug
Imatinib
Metastatic breast cancer
Trastuzamab
Targets her2/neu receptors of breast cancer cells
Trastuzamab
Block VEGF binding to VEGFR to lessen vascular permeability
High vascular flow and drug delivery
Bevacizumab
Induces complement mediated tumor lysis, direct cytotoxicity and apoptosis
Rituximab
Side effect of asparaginase
Acute pancreatitis
Differentiation therapy
All trans retinoic acid
Side effect of all trans retinoic acid therapy
Retinoic acid syndrome (tx dexamethasone)
Glucocorticoid triggering apoptosis and act on non-dividing cancer cells
Prednisone
Tamoxifen-resistant breast cancer
Anastrozole
Decadron side effect
Puffy face
Chemotherapeutic drugs that cause marked myelosuppression
5FU, 6MP, Methotrexate
Vincristine side effect
Peripheral neuropathy