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Pharmacology > Gonadal Hormones and Inhibitors > Flashcards

Gonadal Hormones and Inhibitors Flashcards

1
Q

Ovarian Hormone MOA

A

modulation of gene expression

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2
Q

Major ovarian estrogen in women

A

Estradiol

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3
Q

Mixtures of conjugated estrogens from biologic sources

A

Premarin

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4
Q

Used as HRT

A

Premarin

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5
Q

Used as Hormonal Contraceptive

A

Ethinyl Estradiol, Mestranol

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6
Q

Synthetic estrogens with high bioavailability

A

Ethinyl Estradiol, Mestranol

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7
Q

Used as Hormonal Contraceptive

A

Synthetic estrogens with high bioavailability

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8
Q

Used as HRT

A

Mixtures of conjugated estrogens from biologic sources

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9
Q

Synthetic estrogen MOA

A

Estrogen receptor activation

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10
Q

Estrogen used for contraception

A

Ethinyl estradiol, Mestranol, Estradiol cypionate

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11
Q

Estrogen used for hormone replacement

A

Ethinyl estradiol, Mestranol, Estradiol cypionate

Diethylstilbestrol

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12
Q

Atrophic vaginitis DOC

A

Diethylstilbestrol

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13
Q

Increases risk for Endometrial and Breast Ca

A

Synthetic Estrogen

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14
Q

Increases risk for Clear Cell Vaginal Adenocarcinoma in daughters with mothers who took what synthetic estrogen

A

Diethylstilbestrol

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15
Q

Progestins

A

Norgestrel (-gest, -nodiol, -nor)

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16
Q

Synthetic progesterone MOA

A

Progesterone receptor activation

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17
Q

Indications for Progestint

A

HRT
Contraception
Assisted reproduction
Anovulation induction

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18
Q

Progestins are combined with Estrogen for HRT to decrease risk of

A

Endometrial Ca

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19
Q

Progestin used as an appetite stimulant

A

Megestrol

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20
Q

Combination of estrogen-progestin tablets taken in constant dosage throughout the menstrual cycle

A

Monophasic

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21
Q

Combination of estrogen and progestin where drug dosage of either changes during the month

A

Biphasic

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22
Q

Type of OCP closely mimicking hormonal change in the menstrual cycle

A

Biphasic

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23
Q

Regimen for emergency contraception

A

Yuzpe regimen

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24
Q

Window period for administering emergency contraception

A

72 hours post-coitus

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25
Q

Primary action of combined hormonal contraceptive

A

inhibition of ovulation

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26
Q

T/F: Combined OCP does not change lifetime risk of breast cancer.

A

True

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27
Q

Anti-androgenic progestin

A

Drospirenone

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28
Q

Progestin-only OCP

A

Medroxyprogesterone acetate

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29
Q

Intramuscular progestin-only OCP

A

Depo-provera

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30
Q

T/F: Breakthrough bleeding occurs in between menstrual period

A

True

31
Q

Yuzpe regimen

A

Levonorgestrel + Ethinyl Estradiol

32
Q

Drugs that are mixed estrogen agonists: agonist in some tissues, partial agonist or antagonist in other tissues

A

Selective Estrogen Receptor Modulator (SERM)

33
Q

SERM

A

Tamoxifen, Raloxifene, Clomiphene (-fen, -phene)

34
Q

Tamoxifen SimD

A

Toremifene

35
Q

Tamoxifen MOA

A

Estrogen antagonist in breast and CNS

Estrogen agonist in uterus, liver and bone

36
Q

Tamoxifen side effect

A

Endometrial hyperplasia and Endometrial Ca

37
Q

Protective effect of Tamoxifen

A

Osteoporosis and Atherosclerosis

38
Q

Tamoxifen indication

A

Hormone-responsive Breast Ca

39
Q

Raloxifene MOA

A

Estrogen antagonist in breast, CNS and UTERUS

Estrogen agonist in liver and bone

40
Q

Raloxifene indication

A

breast cancer prevention

41
Q

Partial estrogen agonist in pituitary

Reduce estradiol negative feedback cause increase in FSH and LSH output

A

Clomiphene

42
Q

SERM used for induction of ovulation

A

Clomiphene

43
Q

Clomiphene side effect

A

Multiple pregnancies

Ovarian enlargement

44
Q

SERM with increased risk of Ovarian Ca with long term use

A

Clomiphene

45
Q

Estrogen synthesis inhibitor

A

Anastrozole, Letrozole, Exemestane

46
Q

Anastrozole MOA

A

Inhibits Aromatase

47
Q

Breast Ca resistant to Tamoxifen DOC

A

Anastrozole

48
Q

Ovarian inhibitor

A

Danazol

49
Q

Partial progestin and androgen receptor agonist

A

Danazol

50
Q

Endometriosis DOC

A

Danazol

51
Q

Contraindication of Danazol

A

Pregnancy and breast feeding

52
Q

GnRH antagonist that prevents premature LH surge

A

Ganirelix

53
Q

Glucocorticoid receptor antagonist

Progesterone receptor antagonist

A

Mifepristone

54
Q

Mifepristone

A

RU 486

55
Q

Medical abortifacient

A

Mifepristone

56
Q

Usually combined with Mifepristone for medical abortion

A

Misoprostol

57
Q

Abortion cause sepsis due to which organism

A

Clostridium sordelli

58
Q

Precursors of Testosterone

A

DHEA and progesterone

59
Q

Converts Testosterone to DHT

A

5 alpha reductase

60
Q

Clinical use of testosterone

A

hypogonadism
stimulate RBC production in anemia
weight gain
performance-enhancer

61
Q

Male side effect of testosterone

A

Paradoxical feminization

62
Q

Female side effect of testosteron

A

Virilization

63
Q

Contraindication of testosterone

A

Pregnancy and Prostate Ca

64
Q

Androgen receptor agonist used for illegal performance enhancement in athletes

A

Oxandrolone

65
Q

Hepatic side effect of OCP

A

Hepatic adenoma

66
Q

Hepatic side effect of Oxandrolone

A

Hepatocellular Ca and Cholestatic Jaundice

67
Q

Flutamide MOA

A

Androgen receptor antagonist

68
Q

Used for surgical castration

A

Nilutamide

69
Q

Prevents acute flare up of prostate tumor in patients receiving Leuprolide

A

Flutamide

70
Q

Does not cause acute flare up of prostate tumor

A

Ganirelix

71
Q

Androgen receptor antagonist used for decreasing sexual drive in men

A

Cyproterone acetate (Orphan Drug status)

72
Q

Inhibits 5 alpha reductase

A

Finasteride, Dutasteride

73
Q

Benigh Prostatic Hyperplasia DOC

A

Finasteride

74
Q

Male-pattern baldness DOC

A

Finasteride

Pharmacology (31 decks)

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