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Pharmacology > Gonadal Hormones and Inhibitors > Flashcards

Gonadal Hormones and Inhibitors Flashcards

1
Q

Ovarian Hormone MOA

A

modulation of gene expression

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2
Q

Major ovarian estrogen in women

A

Estradiol

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3
Q

Mixtures of conjugated estrogens from biologic sources

A

Premarin

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4
Q

Used as HRT

A

Premarin

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5
Q

Used as Hormonal Contraceptive

A

Ethinyl Estradiol, Mestranol

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6
Q

Synthetic estrogens with high bioavailability

A

Ethinyl Estradiol, Mestranol

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7
Q

Used as Hormonal Contraceptive

A

Synthetic estrogens with high bioavailability

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8
Q

Used as HRT

A

Mixtures of conjugated estrogens from biologic sources

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9
Q

Synthetic estrogen MOA

A

Estrogen receptor activation

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10
Q

Estrogen used for contraception

A

Ethinyl estradiol, Mestranol, Estradiol cypionate

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11
Q

Estrogen used for hormone replacement

A

Ethinyl estradiol, Mestranol, Estradiol cypionate

Diethylstilbestrol

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12
Q

Atrophic vaginitis DOC

A

Diethylstilbestrol

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13
Q

Increases risk for Endometrial and Breast Ca

A

Synthetic Estrogen

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14
Q

Increases risk for Clear Cell Vaginal Adenocarcinoma in daughters with mothers who took what synthetic estrogen

A

Diethylstilbestrol

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15
Q

Progestins

A

Norgestrel (-gest, -nodiol, -nor)

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16
Q

Synthetic progesterone MOA

A

Progesterone receptor activation

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17
Q

Indications for Progestint

A

HRT
Contraception
Assisted reproduction
Anovulation induction

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18
Q

Progestins are combined with Estrogen for HRT to decrease risk of

A

Endometrial Ca

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19
Q

Progestin used as an appetite stimulant

A

Megestrol

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20
Q

Combination of estrogen-progestin tablets taken in constant dosage throughout the menstrual cycle

A

Monophasic

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21
Q

Combination of estrogen and progestin where drug dosage of either changes during the month

A

Biphasic

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22
Q

Type of OCP closely mimicking hormonal change in the menstrual cycle

A

Biphasic

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23
Q

Regimen for emergency contraception

A

Yuzpe regimen

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24
Q

Window period for administering emergency contraception

A

72 hours post-coitus

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25
Primary action of combined hormonal contraceptive
inhibition of ovulation
26
T/F: Combined OCP does not change lifetime risk of breast cancer.
True
27
Anti-androgenic progestin
Drospirenone
28
Progestin-only OCP
Medroxyprogesterone acetate
29
Intramuscular progestin-only OCP
Depo-provera
30
T/F: Breakthrough bleeding occurs in between menstrual period
True
31
Yuzpe regimen
Levonorgestrel + Ethinyl Estradiol
32
Drugs that are mixed estrogen agonists: agonist in some tissues, partial agonist or antagonist in other tissues
Selective Estrogen Receptor Modulator (SERM)
33
SERM
Tamoxifen, Raloxifene, Clomiphene (-fen, -phene)
34
Tamoxifen SimD
Toremifene
35
Tamoxifen MOA
Estrogen antagonist in breast and CNS | Estrogen agonist in uterus, liver and bone
36
Tamoxifen side effect
Endometrial hyperplasia and Endometrial Ca
37
Protective effect of Tamoxifen
Osteoporosis and Atherosclerosis
38
Tamoxifen indication
Hormone-responsive Breast Ca
39
Raloxifene MOA
Estrogen antagonist in breast, CNS and UTERUS | Estrogen agonist in liver and bone
40
Raloxifene indication
breast cancer prevention
41
Partial estrogen agonist in pituitary | Reduce estradiol negative feedback cause increase in FSH and LSH output
Clomiphene
42
SERM used for induction of ovulation
Clomiphene
43
Clomiphene side effect
Multiple pregnancies | Ovarian enlargement
44
SERM with increased risk of Ovarian Ca with long term use
Clomiphene
45
Estrogen synthesis inhibitor
Anastrozole, Letrozole, Exemestane
46
Anastrozole MOA
Inhibits Aromatase
47
Breast Ca resistant to Tamoxifen DOC
Anastrozole
48
Ovarian inhibitor
Danazol
49
Partial progestin and androgen receptor agonist
Danazol
50
Endometriosis DOC
Danazol
51
Contraindication of Danazol
Pregnancy and breast feeding
52
GnRH antagonist that prevents premature LH surge
Ganirelix
53
Glucocorticoid receptor antagonist | Progesterone receptor antagonist
Mifepristone
54
Mifepristone
RU 486
55
Medical abortifacient
Mifepristone
56
Usually combined with Mifepristone for medical abortion
Misoprostol
57
Abortion cause sepsis due to which organism
Clostridium sordelli
58
Precursors of Testosterone
DHEA and progesterone
59
Converts Testosterone to DHT
5 alpha reductase
60
Clinical use of testosterone
hypogonadism stimulate RBC production in anemia weight gain performance-enhancer
61
Male side effect of testosterone
Paradoxical feminization
62
Female side effect of testosteron
Virilization
63
Contraindication of testosterone
Pregnancy and Prostate Ca
64
Androgen receptor agonist used for illegal performance enhancement in athletes
Oxandrolone
65
Hepatic side effect of OCP
Hepatic adenoma
66
Hepatic side effect of Oxandrolone
Hepatocellular Ca and Cholestatic Jaundice
67
Flutamide MOA
Androgen receptor antagonist
68
Used for surgical castration
Nilutamide
69
Prevents acute flare up of prostate tumor in patients receiving Leuprolide
Flutamide
70
Does not cause acute flare up of prostate tumor
Ganirelix
71
Androgen receptor antagonist used for decreasing sexual drive in men
Cyproterone acetate (Orphan Drug status)
72
Inhibits 5 alpha reductase
Finasteride, Dutasteride
73
Benigh Prostatic Hyperplasia DOC
Finasteride
74
Male-pattern baldness DOC
Finasteride

Pharmacology (31 decks)

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