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Pharmacology > Bacterial Protein Synthesis Inhibitor > Flashcards

Bacterial Protein Synthesis Inhibitor Flashcards

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1
Q

Chloramphenicol side effects

A

Aplastic Anemia

Gray Baby Syndrome

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2
Q

Infant with meningitis receives Chloramphenicol and develops ashen gray skin, cyanosis and cardiovascular collaps. Labs show decrease in RBC.

A

Gray Baby Syndrome

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3
Q

Enzyme deficient in infants that metabolize Chloramphenicol

A

Hepatic glucoronyltransferase

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4
Q

Macrolides

A

Erythromycin, Azithromycin, Clarithromycin, Telithromycin

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5
Q

Pneumonia, DPT, Chlamydia

A

Macrolides

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6
Q

Liquid that should not be ingested with Tetracycline

A

Milk

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7
Q

Macrolide that does not inhibit CYP450

A

Azithromycin

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8
Q

Macrolide with highest Vd and slowest elimination

A

Azithromycin

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9
Q

Macrolide used for Macrolide-resistance

A

Telithromycin

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10
Q

Lincosamide

A

Clindamycin, Lincomycin

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11
Q

Anaerobic infections above the diaphragm

A

Clindamycin

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12
Q

Most common side effect of Clindamycin

A

Pseudomembranous colitis

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13
Q

Etiology of pseudomembranous colitis as side effect of Clindamycin

A

Overgrowth of Clostridium Difficile

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14
Q

Cross reacts with Clindamycin

A

Macrolides

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15
Q

Anaerobic infections below the diaphragm

A

Metronidazole

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16
Q

Linezolid Class

A

Oxalidinone

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17
Q

Gram + MRSA, VRSA, VRE, Listeria and Corynebacterium

A

Linezolid

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18
Q

Gram + MRSA, VRSA, VRE

A

Streptogrammins

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19
Q

Streptogrammins

A

Quinupristin-Dalfopristin

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20
Q

Arthralgia-Myalgia Syndrome

A

Streptogrammins

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21
Q

Multiple drug reactions

A

Streptogrammins, Linezolid

22
Q

Tetracycline

A

Doxycycline, Minocycline, Tigecycline, Demeclocycline

23
Q

Tetracycline MOA

A

Blocks attachment of tRNA to acceptor A site

24
Q

Teratogenic effect of Tetracycline

A

Tooth enamel dysplasia and discoloration

25
Q

Broad spectrum Tetracycline

A

Tigecycline

26
Q

Tetracycline used for SIADH

A

Demeclocycline

27
Q

Lyme, Vibrio, Mycoplasma, Chlamydia, Helicobacter, Amebiasis, Rickettsia, Malaria

A

Tetracycline

28
Q

Aminoglycoside Pharmacokinetics

A

Must be given IM or IV
Limited tissue perfusion
Renal excretion

29
Q

Aminoglycoside with the narrowest therapeutic index

A

Amikacin

30
Q

Requires oxygen to cause antibacterial effect

A

Aminoglycosides

31
Q

MOA of Protein Synthesis Inhibitors

A

block initiation complex formation
misreading of mRNA code
inhibit translocation

32
Q

MOA of Aminoglycoside resistance

A

plasmid-mediated formation of group transferases that act as inactivating enzymes

33
Q

Aminoglycoside resistant to inactivating enzymes

A

Amikacin

34
Q

MOA of Streptomycin resistance

A

ribosomal binding site changes

35
Q

Gram (-) Aerobe

A

E. Coli, Enterobacter, Klebsiella, Proteus, Providencia, Pseudomonas, Serratia

36
Q

Side effects of Aminoglycosides

A

Reversible Nephrotoxicity

Irreversible Ototoxicity

37
Q

Reversible Nephrotoxicity caused by Aminoglycosides

A

Acute Tubular Necrosis

38
Q

Most Ototoxic Aminoglycoside

A

Kanamycin, Amikacin

39
Q

Most Vestibulotoxic Aminoglycoside

A

Gentamicin, Tobramycin

40
Q

Most Nephrotoxic Aminoglycoside

A

Tobramycin, Gentamicin

41
Q

Aminoglycoside with Curare-effect

A

Neomycin

42
Q

Treatment for Neomycin-induced curare-effect

A

Calcium Gluconate, Neostigmine

43
Q

Gentamicin coverage

A

Gram (-) Aerobe

44
Q

Amikacin coverage

A

Gram (-) Aerobe, MDR TB

45
Q

TB, Tularemia, Bubonic plague, Brucellosis

A

Streptomycin

46
Q

Teratogenic effect of Streptomycin

A

Congenital Deafness

47
Q

Route of administration of Neomycin

A

Topical and Oral

48
Q

Route of administration of Streptomycin

A

Intramuscular

49
Q

Neomycin SimD

A

Kanamycin, Paramomycin

50
Q

Visceral Leishmaniasis (Kala-Azar) DOC

A

Paramomycin

51
Q

Side effect of Neomycin

A

Hepatic Encephalopathy

52
Q

Drug-resistant Gonorrhea DOC

A

Spectinomycin

Pharmacology (31 decks)

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