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Pharmacology > Bacterial Protein Synthesis Inhibitor > Flashcards

Bacterial Protein Synthesis Inhibitor Flashcards

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1
Q

Chloramphenicol side effects

A

Aplastic Anemia

Gray Baby Syndrome

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2
Q

Infant with meningitis receives Chloramphenicol and develops ashen gray skin, cyanosis and cardiovascular collaps. Labs show decrease in RBC.

A

Gray Baby Syndrome

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3
Q

Enzyme deficient in infants that metabolize Chloramphenicol

A

Hepatic glucoronyltransferase

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4
Q

Macrolides

A

Erythromycin, Azithromycin, Clarithromycin, Telithromycin

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5
Q

Pneumonia, DPT, Chlamydia

A

Macrolides

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6
Q

Liquid that should not be ingested with Tetracycline

A

Milk

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7
Q

Macrolide that does not inhibit CYP450

A

Azithromycin

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8
Q

Macrolide with highest Vd and slowest elimination

A

Azithromycin

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9
Q

Macrolide used for Macrolide-resistance

A

Telithromycin

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10
Q

Lincosamide

A

Clindamycin, Lincomycin

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11
Q

Anaerobic infections above the diaphragm

A

Clindamycin

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12
Q

Most common side effect of Clindamycin

A

Pseudomembranous colitis

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13
Q

Etiology of pseudomembranous colitis as side effect of Clindamycin

A

Overgrowth of Clostridium Difficile

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14
Q

Cross reacts with Clindamycin

A

Macrolides

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15
Q

Anaerobic infections below the diaphragm

A

Metronidazole

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16
Q

Linezolid Class

A

Oxalidinone

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17
Q

Gram + MRSA, VRSA, VRE, Listeria and Corynebacterium

A

Linezolid

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18
Q

Gram + MRSA, VRSA, VRE

A

Streptogrammins

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19
Q

Streptogrammins

A

Quinupristin-Dalfopristin

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20
Q

Arthralgia-Myalgia Syndrome

A

Streptogrammins

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21
Q

Multiple drug reactions

A

Streptogrammins, Linezolid

22
Q

Tetracycline

A

Doxycycline, Minocycline, Tigecycline, Demeclocycline

23
Q

Tetracycline MOA

A

Blocks attachment of tRNA to acceptor A site

24
Q

Teratogenic effect of Tetracycline

A

Tooth enamel dysplasia and discoloration

25
Broad spectrum Tetracycline
Tigecycline
26
Tetracycline used for SIADH
Demeclocycline
27
Lyme, Vibrio, Mycoplasma, Chlamydia, Helicobacter, Amebiasis, Rickettsia, Malaria
Tetracycline
28
Aminoglycoside Pharmacokinetics
Must be given IM or IV Limited tissue perfusion Renal excretion
29
Aminoglycoside with the narrowest therapeutic index
Amikacin
30
Requires oxygen to cause antibacterial effect
Aminoglycosides
31
MOA of Protein Synthesis Inhibitors
block initiation complex formation misreading of mRNA code inhibit translocation
32
MOA of Aminoglycoside resistance
plasmid-mediated formation of group transferases that act as inactivating enzymes
33
Aminoglycoside resistant to inactivating enzymes
Amikacin
34
MOA of Streptomycin resistance
ribosomal binding site changes
35
Gram (-) Aerobe
E. Coli, Enterobacter, Klebsiella, Proteus, Providencia, Pseudomonas, Serratia
36
Side effects of Aminoglycosides
Reversible Nephrotoxicity | Irreversible Ototoxicity
37
Reversible Nephrotoxicity caused by Aminoglycosides
Acute Tubular Necrosis
38
Most Ototoxic Aminoglycoside
Kanamycin, Amikacin
39
Most Vestibulotoxic Aminoglycoside
Gentamicin, Tobramycin
40
Most Nephrotoxic Aminoglycoside
Tobramycin, Gentamicin
41
Aminoglycoside with Curare-effect
Neomycin
42
Treatment for Neomycin-induced curare-effect
Calcium Gluconate, Neostigmine
43
Gentamicin coverage
Gram (-) Aerobe
44
Amikacin coverage
Gram (-) Aerobe, MDR TB
45
TB, Tularemia, Bubonic plague, Brucellosis
Streptomycin
46
Teratogenic effect of Streptomycin
Congenital Deafness
47
Route of administration of Neomycin
Topical and Oral
48
Route of administration of Streptomycin
Intramuscular
49
Neomycin SimD
Kanamycin, Paramomycin
50
Visceral Leishmaniasis (Kala-Azar) DOC
Paramomycin
51
Side effect of Neomycin
Hepatic Encephalopathy
52
Drug-resistant Gonorrhea DOC
Spectinomycin

Pharmacology (31 decks)

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