Antidepressants Flashcards
Tricyclic depressants
Desipramine, Amitryptiline, Nortryptiline, IMIPRAMINE, Clomipramine
(-amine, -tyline)
Brain amines that serve as neurotransmitters of mood
Norepinephrine and Serotonin
TCA MOA
Block NE and 5HT transport
TCA overdose
Coma, Convulsion, Cardiotoxicity
Antidepressant with sympathomimetic side effects
TCA
TCA toxic dose
7 mg/kg
TCA lethal dose
15 mg/kg
ECG findings of cardiotoxic TCA
Prolonged QRS
Reverses TCA cardiotoxicity
Bicarbonate
Major Depresseive Disorder DOC
Fluoxetine
SSRI
Sertraline, Citalopram, Escitalopram, Paroxetine, FLUOXETINE, Fluvoxamine
(SER PRAMiSS, di gagana ang PARecoxib sa FLU)
SSRI + MAO-B inihibitor
Serotonin syndrome
SSRI MOA
Inhibits neuronal reuptake of serotonin
SNRI MOA
inhibits neuronal reuptake of NE and serotonin
Antidepressant that causes erectile dysfunction
SSRI
SNRI
VENLAFAXINE, Desvenlafaxine, Duloxetine
fax sa dulo ng SNr
Serotonin antagonist
Trazodone, Nefazodone
Trazodone MOA
Blocks 5HT2 receptor
Antidepressant causing priapism
Trazodone and Bupropion
Tetracyclic antidepressant
Amoxapine, Mirtazapine, Bupropion
Amoxapine MOA
NE reuptake inhibitor»_space; Serotonin reuptake inhibitor
Blocks Dopamine D2 receptor
Antidepressant that lowers seizure threshold
Amoxapine and Bupropion
Mirtazapine
Presynaptic Alpha 2 adrenoreceptor antagonist
Serotonin 5 HT2 blocker
Antidepressant causing appetite stimulation
Mirtazapine
Bupropion MOA
Inhibit reuptake of dopamine and norepinephrine, increasing its activity
Antidepressant given for smoking cessation
Bupropion
MAO inhibitor MOA
Inhibit MAO A and B
Increase CNS norepinephrine and serotonin
MAO inhibitors
Phenelzine, Selegiline, Tranylcypromine
MAO inhibitor + tyramine (cheese)
Hypertensive crisis
Serotonin syndrome treatment
Cyproheptadine
Serotonin Syndrome
Fever, Agitation, Tremors, Clonus, Hyperreflexia, Diaphoresi
Malignant Hyperthermia
Fever, Acidosis, Rhabdomyolysis, Trismus, Clonus, Hypertension
Neuroleptic Malignant Syndrome
Fever, Encehalopathy, Vitals unstable, Elevated CPK, Rigidity