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Pharmacology > Antidepressants > Flashcards

Antidepressants Flashcards

0
Q

Tricyclic depressants

A

Desipramine, Amitryptiline, Nortryptiline, IMIPRAMINE, Clomipramine
(-amine, -tyline)

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1
Q

Brain amines that serve as neurotransmitters of mood

A

Norepinephrine and Serotonin

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2
Q

TCA MOA

A

Block NE and 5HT transport

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3
Q

TCA overdose

A

Coma, Convulsion, Cardiotoxicity

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4
Q

Antidepressant with sympathomimetic side effects

A

TCA

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5
Q

TCA toxic dose

A

7 mg/kg

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6
Q

TCA lethal dose

A

15 mg/kg

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7
Q

ECG findings of cardiotoxic TCA

A

Prolonged QRS

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8
Q

Reverses TCA cardiotoxicity

A

Bicarbonate

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9
Q

Major Depresseive Disorder DOC

A

Fluoxetine

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10
Q

SSRI

A

Sertraline, Citalopram, Escitalopram, Paroxetine, FLUOXETINE, Fluvoxamine
(SER PRAMiSS, di gagana ang PARecoxib sa FLU)

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11
Q

SSRI + MAO-B inihibitor

A

Serotonin syndrome

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12
Q

SSRI MOA

A

Inhibits neuronal reuptake of serotonin

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13
Q

SNRI MOA

A

inhibits neuronal reuptake of NE and serotonin

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14
Q

Antidepressant that causes erectile dysfunction

A

SSRI

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15
Q

SNRI

A

VENLAFAXINE, Desvenlafaxine, Duloxetine

fax sa dulo ng SNr

16
Q

Serotonin antagonist

A

Trazodone, Nefazodone

17
Q

Trazodone MOA

A

Blocks 5HT2 receptor

18
Q

Antidepressant causing priapism

A

Trazodone and Bupropion

19
Q

Tetracyclic antidepressant

A

Amoxapine, Mirtazapine, Bupropion

20
Q

Amoxapine MOA

A

NE reuptake inhibitor&raquo_space; Serotonin reuptake inhibitor

Blocks Dopamine D2 receptor

21
Q

Antidepressant that lowers seizure threshold

A

Amoxapine and Bupropion

22
Q

Mirtazapine

A

Presynaptic Alpha 2 adrenoreceptor antagonist

Serotonin 5 HT2 blocker

23
Q

Antidepressant causing appetite stimulation

A

Mirtazapine

24
Q

Bupropion MOA

A

Inhibit reuptake of dopamine and norepinephrine, increasing its activity

25
Q

Antidepressant given for smoking cessation

A

Bupropion

26
Q

MAO inhibitor MOA

A

Inhibit MAO A and B

Increase CNS norepinephrine and serotonin

27
Q

MAO inhibitors

A

Phenelzine, Selegiline, Tranylcypromine

28
Q

MAO inhibitor + tyramine (cheese)

A

Hypertensive crisis

29
Q

Serotonin syndrome treatment

A

Cyproheptadine

30
Q

Serotonin Syndrome

A

Fever, Agitation, Tremors, Clonus, Hyperreflexia, Diaphoresi

31
Q

Malignant Hyperthermia

A

Fever, Acidosis, Rhabdomyolysis, Trismus, Clonus, Hypertension

32
Q

Neuroleptic Malignant Syndrome

A

Fever, Encehalopathy, Vitals unstable, Elevated CPK, Rigidity

Pharmacology (31 decks)

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