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Pharmacology > Muscle Relaxants > Flashcards

Muscle Relaxants Flashcards

0
Q

Drugs used to reduce abnormally elevated tone caused by neurologic or muscle end plste disease

A

Spasmolytic drugs

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1
Q

Drugs used to produce muscle paralysis to facilitate surgery or assisted ventilation

A

Neuromuscular blocking drugs

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2
Q

Type of NM blockade: paralysis from persistent depolarization of the end plate

A

Depolarizing blockade

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3
Q

Type of NM blockade: paralysis from pharmacologic antagonism of Ach receptors at the end plate

A

Non-depolarizing / Stabilizing blockade

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4
Q

Reverses non-depolarizing blockade

A

NEOSTIGMINE

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5
Q

Non-depolarizing blocker with the most rapid time of onset

A

Rocuronium

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6
Q

Short acting non-depolarizing NM blocker

A

Mivacurium

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7
Q

Indication for non-depolarizing blocker

A

Skeletal muscle relaxation during intubation and general anesthesia

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8
Q

Neostigmine MOA

A

Cholinesterase inhibitor

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9
Q

Non-depolaring NM blocker MOA

A

Competitive antagonist at skeletal muscle nicotinic Ach receptor

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10
Q

Muscle relaxant metabolized by pseudocholinesterase

A

Mivacurium

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11
Q

Intermediate acting non-depolarizing NM blocker

A

Rocuronium
Atracurium
Vecuronium

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12
Q

Nover reversal agent for Rocuronium

A

Sugammadex

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13
Q

Non-depolarizing NM blocker causing bronchospasm

A

Atracurium

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14
Q

Rapid spontaneous elimination of Atracurium

A

Hoffman Elimination

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15
Q

Non-depolarizing NM blocker eliminated in the bile

A

Vecuronium

16
Q

Long acting non-depolarizing NM blocker

A

Pancuronium & Tubocurarine

17
Q

Lethal Injection cocktail

A

Thiopental, Pancuronium, Potassium chloride

18
Q

Phase of Depolarizing NM blockade:

Initial electric discharge - Membrane depolarizes - Transient fasiculations - Flaccid paralysis

A

Phase 1 - Depolarization

19
Q

Phase of Depolarizing NM blockade:

Membrane repolarizes - Receptor does not respond to Ach

A

Phase 2 - Desensitization

20
Q

Initial twitch then persistent depolarization

A

Depolarizing NM blocker

21
Q

Metabolized by pseudocholinesterase

A

Mivacurium and Succinylcholine

22
Q

Interaction involved with Malignant Hyperthermia

A

Succinylcholine and Halothane

23
Q

Massive calcium release by the SR of the skeletal muscle, mediated by ryanodin receptors

A

Malignant Hyperthermia

24
Q

Early sign of Malignant hyperthermia

A

Trismus

25
Q

Malignant hyperthermia DOC

A

Dantrolene

Pharmacology (31 decks)

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