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Pharmacology > Opioids > Flashcards

Opioids Flashcards

0
Q

Opioid with shortest half life

A

Remifentanil

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1
Q

Opioid spectrum of use

A

Analgesic, antitussive, antidiarrheal

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2
Q

Opioid with longest half life

A

Buprenorphine

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3
Q

Mu opioid receptor function

A

Inhibition of respiration

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4
Q

Mu opioid receptor affinity

A

Endorphins

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5
Q

Delta opioid receptor function

A

Tolerance

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6
Q

Delta opioid receptor affinity

A

Enkephalins

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7
Q

Kappa opioid receptor function

A

Slowed GI transit

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8
Q

Kappa opioid receptor affinity

A

Dynorphin

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9
Q

Morphine effects

A

Miosis, Orthostatic hypotension, Respiratory depression, Pain relief, Histamine release, Increased ICP, Nausea, Euphoria

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10
Q

Morphine MOA

A

Mu receptor agonist

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11
Q

Fentanyl MOA

A

Mu receptor agonist

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12
Q

Most potent opioid (18000x)

A

Ohmefentanyl

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13
Q

Route of administration of Fentanyl

A

Transdermal or Lollipop

IV (anesthesia)

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14
Q

Meperidine MOA

A

Mu and Kappa receptor agonist

Muscarinic blockade

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15
Q

Pancreatitis pain relief DOC

A

Meperidine

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16
Q

Opioid analgesic that does not cause miosis or biliary spasm

A

Meperidine

17
Q

Strong agonist at mu opioid receptors
Binds NMDA receptors
Glutamate antagonist

A

Methadone MOA

18
Q

Opioid for Opioid withdrawal/dependence

A

Methadone (Methadone Maintenance Therapy)

19
Q

Hydrocodone MOA

A

Mu and Kappa opioid receptor agonist

20
Q

Hydrocodone side effect

A

Hypogonadism and hearing loss

21
Q

Full opioid agonist

A

Morphine, Fentanyl, Meperidine, Methadone

22
Q

Partial opioid agonist

A

Hydrocodone, Dextromethorphan

23
Q

Dextromethorphan MOA

A

Sigma receptor stimulation depredd medullary cough center

24
Q

Dextromethorphan SimD

A

Codeine

25
Q

Codeine indication

A

Cough

26
Q

Weak opioid agonist

A

Propoxyphene

27
Q

Opioid agonist that cause fatal cardiotoxicity hence withdrawn

A

Propoxyphene

28
Q

Nalbuphine MOA

A

Kappa opioid receptor agonist

Mu opioid recetor ANTAgonist

29
Q

Mixed agonist-antagonist opioid

A

Nalbuphine

30
Q

Nalbuphine SimD

A

Buprenorphine, Butorphanol, Pentazocine

31
Q

Opioid resistant to naloxone reversal

A

Nalbuphine

32
Q

Opioid that decreases alcohol dependence

A

Buprenorphine

33
Q

Opioid antagonist

A

Naloxone

34
Q

Naloxone SimD

A

Naltrexone, Nalmefene

35
Q

Side effect of Naloxone in opioid dependent patients

A

Abstinence syndrome

36
Q

Tramadol MOA

A

Weak mu opioid receptor agonist

Inhibit uptake of NE and serotonin

37
Q

Side effect/contraindication of Tramadol

A

Seizures

38
Q

Tramadol SimD

A

Tapentadol

39
Q

Opioid overdose

A

Pupillary constriction, Coma, Respiratory Depression

Pharmacology (31 decks)

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