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Pharmacology > Corticosteroids > Flashcards

Corticosteroids Flashcards

1
Q

Prototype glucocorticoid

A

Hydrocortisone

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2
Q

Short acting glucocorticoid

A

Hydrocortisone

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3
Q

Low potency hydrocortisone

A

Desonide

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4
Q

Medium potency hydrocortisone

A

Fluticasone and Mometasone

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5
Q

High potency hydrocortisone

A

Desoximetasone and Clobetasol

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6
Q

Acute adrenal insufficiency DOC

A

Cortisol

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7
Q

T/F Glucocorticoids may be used for cerebral edema

A

True

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8
Q

T/F Glucocorticoids may be used for increased ICP

A

False

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9
Q

Most common side effect of medium to long acting glucocorticoid

A

Behavioral changes (Steroid rage)

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10
Q

Long acting glucocorticoid that hastens fetal lung maturation

A

Betamethasone

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11
Q

Drug dose given during serious illness or prior to surgery in patients on long term steroid therapy

A

Stress doses

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12
Q

Stress doses avoid what condition

A

Adrenal Insufficiency

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13
Q

Most common cause of acute adrenal insufficiency

A

Waterhouse-Friderichsen Syndrome

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14
Q

Most common cause of chronic adrenal insufficiency

A

Addison’s Disease

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15
Q

Drug dose regimen to avoid adrenal crisis in patients being withdrawn from long term steroid therapy

A

dose-tapering

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16
Q

Mineralocorticoid receptor agonist with moderate activation of Glucocorticoid receptor

A

Fludrocortisone and Deoxycorticosterone

17
Q

Chronic adrenal insufficiency DOC

A

Fludrocortisone

18
Q

Post-adrenalectomy adrenal replacement therapy

A

Fludrocortisone

19
Q

Adrenal excess

A

Conn’s Disease

20
Q

Congenital Adrenal Hyperplasia DOC

A

Fludrocortisone

21
Q

Elevated glucocorticoid levels

A

Cushing’s Syndrome

22
Q

Elevated mineralocorticoid levels

A

Conn’s Disease

23
Q

Adrenal insufficiency

A

Addison’s Disease

24
Q

Most common cause of iatrogenic cushing’s syndrome

A

Increase exogenous intake

25
Q

Cortisol-secreting adrenal adenoma

A

Adrenal Cushing’s Syndrome

26
Q

ACTH-secreting pituitary adenoma

A

Pituitary Cushing’s Syndrome (Cushing’s Disease)

27
Q

Paraneoplastic ACTH production (Small Cell Lung Ca)

A

Ectopic Cushing’s Syndrome

28
Q

Glucocorticoid synthesis inhibitors

A

Aminoglutethimide, Ketoconazole, Metyrapone

29
Q

Glucocorticoid synthesis inhibitor used as an antifungal

A

Ketoconazole

30
Q

Pregnant with Cushing’s Syndrome DOC

A

Metyrapone

31
Q

Aminoglutethimide MOA

A

Inhibits Desmolase

32
Q

Converts cholesterol to pregnenolone

33
Q

Abused by body-builders to decrease circulating cortisol levels and prevent muscle loss

A

Aminoglutethimide

34
Q

Inhibits cholesterol side-chain cleavage

A

Ketoconazole

35
Q

Metyrapone MOA

A

Inhibits steroid 11-hydroxylation

Pharmacology (31 decks)

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