Corticosteroids

Question 1

Prototype glucocorticoid

Answer 1

Hydrocortisone

Question 2

Short acting glucocorticoid

Answer 2

Hydrocortisone

Question 3

Low potency hydrocortisone

Answer 3

Desonide

Question 4

Medium potency hydrocortisone

Answer 4

Fluticasone and Mometasone

Question 5

High potency hydrocortisone

Answer 5

Desoximetasone and Clobetasol

Question 6

Acute adrenal insufficiency DOC

Answer 6

Cortisol

Question 7

T/F Glucocorticoids may be used for cerebral edema

Answer 7

True

Question 8

T/F Glucocorticoids may be used for increased ICP

Answer 8

False

Question 9

Most common side effect of medium to long acting glucocorticoid

Answer 9

Behavioral changes (Steroid rage)

Question 10

Long acting glucocorticoid that hastens fetal lung maturation

Answer 10

Betamethasone

Question 11

Drug dose given during serious illness or prior to surgery in patients on long term steroid therapy

Answer 11

Stress doses

Question 12

Stress doses avoid what condition

Answer 12

Adrenal Insufficiency

Question 13

Most common cause of acute adrenal insufficiency

Answer 13

Waterhouse-Friderichsen Syndrome

Question 14

Most common cause of chronic adrenal insufficiency

Answer 14

Addison’s Disease

Question 15

Drug dose regimen to avoid adrenal crisis in patients being withdrawn from long term steroid therapy

Answer 15

dose-tapering

Question 16

Mineralocorticoid receptor agonist with moderate activation of Glucocorticoid receptor

Answer 16

Fludrocortisone and Deoxycorticosterone

Question 17

Chronic adrenal insufficiency DOC

Answer 17

Fludrocortisone

Question 18

Post-adrenalectomy adrenal replacement therapy

Answer 18

Fludrocortisone

Question 19

Adrenal excess

Answer 19

Conn’s Disease

Question 20

Congenital Adrenal Hyperplasia DOC

Answer 20

Fludrocortisone

Question 21

Elevated glucocorticoid levels

Answer 21

Cushing’s Syndrome

Question 22

Elevated mineralocorticoid levels

Answer 22

Conn’s Disease

Question 23

Adrenal insufficiency

Answer 23

Addison’s Disease

Question 24

Most common cause of iatrogenic cushing’s syndrome

Answer 24

Increase exogenous intake

Question 25

Cortisol-secreting adrenal adenoma

Answer 25

Adrenal Cushing’s Syndrome

Question 26

ACTH-secreting pituitary adenoma

Answer 26

Pituitary Cushing’s Syndrome (Cushing’s Disease)

Question 27

Paraneoplastic ACTH production (Small Cell Lung Ca)

Answer 27

Ectopic Cushing’s Syndrome

Question 28

Glucocorticoid synthesis inhibitors

Answer 28

Aminoglutethimide, Ketoconazole, Metyrapone

Question 29

Glucocorticoid synthesis inhibitor used as an antifungal

Answer 29

Ketoconazole

Question 30

Pregnant with Cushing’s Syndrome DOC

Answer 30

Metyrapone

Question 31

Aminoglutethimide MOA

Answer 31

Inhibits Desmolase

Question 32

Converts cholesterol to pregnenolone

Answer 32

Desmolase

Question 33

Abused by body-builders to decrease circulating cortisol levels and prevent muscle loss

Answer 33

Aminoglutethimide

Question 34

Inhibits cholesterol side-chain cleavage

Answer 34

Ketoconazole

Question 35

Metyrapone MOA

Answer 35

Inhibits steroid 11-hydroxylation