Corticosteroids Flashcards
Prototype glucocorticoid
Hydrocortisone
Short acting glucocorticoid
Hydrocortisone
Low potency hydrocortisone
Desonide
Medium potency hydrocortisone
Fluticasone and Mometasone
High potency hydrocortisone
Desoximetasone and Clobetasol
Acute adrenal insufficiency DOC
Cortisol
T/F Glucocorticoids may be used for cerebral edema
True
T/F Glucocorticoids may be used for increased ICP
False
Most common side effect of medium to long acting glucocorticoid
Behavioral changes (Steroid rage)
Long acting glucocorticoid that hastens fetal lung maturation
Betamethasone
Drug dose given during serious illness or prior to surgery in patients on long term steroid therapy
Stress doses
Stress doses avoid what condition
Adrenal Insufficiency
Most common cause of acute adrenal insufficiency
Waterhouse-Friderichsen Syndrome
Most common cause of chronic adrenal insufficiency
Addison’s Disease
Drug dose regimen to avoid adrenal crisis in patients being withdrawn from long term steroid therapy
dose-tapering
Mineralocorticoid receptor agonist with moderate activation of Glucocorticoid receptor
Fludrocortisone and Deoxycorticosterone
Chronic adrenal insufficiency DOC
Fludrocortisone
Post-adrenalectomy adrenal replacement therapy
Fludrocortisone
Adrenal excess
Conn’s Disease
Congenital Adrenal Hyperplasia DOC
Fludrocortisone
Elevated glucocorticoid levels
Cushing’s Syndrome
Elevated mineralocorticoid levels
Conn’s Disease
Adrenal insufficiency
Addison’s Disease
Most common cause of iatrogenic cushing’s syndrome
Increase exogenous intake
Cortisol-secreting adrenal adenoma
Adrenal Cushing’s Syndrome
ACTH-secreting pituitary adenoma
Pituitary Cushing’s Syndrome (Cushing’s Disease)
Paraneoplastic ACTH production (Small Cell Lung Ca)
Ectopic Cushing’s Syndrome
Glucocorticoid synthesis inhibitors
Aminoglutethimide, Ketoconazole, Metyrapone
Glucocorticoid synthesis inhibitor used as an antifungal
Ketoconazole
Pregnant with Cushing’s Syndrome DOC
Metyrapone
Aminoglutethimide MOA
Inhibits Desmolase
Converts cholesterol to pregnenolone
Desmolase
Abused by body-builders to decrease circulating cortisol levels and prevent muscle loss
Aminoglutethimide
Inhibits cholesterol side-chain cleavage
Ketoconazole
Metyrapone MOA
Inhibits steroid 11-hydroxylation