Nucelic Acid Synthesis Inhibitor Flashcards
Nucleic Acid Synthesis Inhibitors
Antifolate, Fluoroquinolones, Metronidazole, Nitrofurantoins
Antifolate drugs
Sulfonamides and Trimethoprim
Short-acting Sulfonamide
Sulfisoxazole
Intermediate-acting Sulfonamide
Sulfamethoxazole
Long-acting Sulfonamide
Sulfadoxine
PABA competing antifolate drug
Sulfonamides
Antifolate drug structurally similar to folic acid
Trimethoprim
Weakly acidic antifolate drug
Sulfonamide
Weakly basic antifolate drug
Trimethoprim
High concentrations in vaginal and prostatic fluid
Trimethoprim
Inhibited by Sulfonamides
Dihydropteroate synthase
Inhibited by Trimethoprim
Dihydrofolate reductase
SMX-TMP MOA
Sequential blockade of folate synthesis
Antifolate drug that must use preformed folic acid to cause effect
Sulfonamide
Antifolate drug resistance MOA
Increased PABA production of bacteria
Decreased sensitivity to sulfonamides
Decreased intracellular accumulation of drugs
Silver Sulfadiazine SimD
Mafenide Acetate
Sulfonamide with best eschar penetration
Silver Sulfadiazine
Precipitated by Sulfonamide use of G6PD patients
Acute hemolysis