Nucelic Acid Synthesis Inhibitor

Question 1

Nucleic Acid Synthesis Inhibitors

Answer 1

Antifolate, Fluoroquinolones, Metronidazole, Nitrofurantoins

Question 2

Antifolate drugs

Answer 2

Sulfonamides and Trimethoprim

Question 3

Short-acting Sulfonamide

Answer 3

Sulfisoxazole

Question 4

Intermediate-acting Sulfonamide

Answer 4

Sulfamethoxazole

Question 5

Long-acting Sulfonamide

Answer 5

Sulfadoxine

Question 6

PABA competing antifolate drug

Answer 6

Sulfonamides

Question 7

Antifolate drug structurally similar to folic acid

Answer 7

Trimethoprim

Question 8

Weakly acidic antifolate drug

Answer 8

Sulfonamide

Question 9

Weakly basic antifolate drug

Answer 9

Trimethoprim

Question 10

High concentrations in vaginal and prostatic fluid

Answer 10

Trimethoprim

Question 11

Inhibited by Sulfonamides

Answer 11

Dihydropteroate synthase

Question 12

Inhibited by Trimethoprim

Answer 12

Dihydrofolate reductase

Question 13

SMX-TMP MOA

Answer 13

Sequential blockade of folate synthesis

Question 14

Antifolate drug that must use preformed folic acid to cause effect

Answer 14

Sulfonamide

Question 15

Antifolate drug resistance MOA

Answer 15

Increased PABA production of bacteria
Decreased sensitivity to sulfonamides
Decreased intracellular accumulation of drugs

Question 16

Silver Sulfadiazine SimD

Answer 16

Mafenide Acetate

Question 17

Sulfonamide with best eschar penetration

Answer 17

Silver Sulfadiazine

Question 18

Precipitated by Sulfonamide use of G6PD patients

Answer 18

Acute hemolysis

Question 19

Co-Trimoxazole coverage

Answer 19

Ear, Sinus, Repiratory, Urinary Tract Infections
Pneumocystic carinii
Toxoplasmosis, Nocardiosis, Typhoid, Shigella

Question 20

Most common side effect of Co-trimoxazole

Answer 20

Hypersensitivity reactions:

TEN, EM, SJS, PAN, Exfoliative dermatitis

Question 21

Fluoroquinolones MOA

Answer 21

inhibit topoisomerase II in Gram (-)

inhibit topoisomerase IV in Gram (+)

Question 22

Fluoroquinolone resistance MOA

Answer 22

decreased intracellular drug accumulation
change in porin structure
point mutations in antibiotic binding regions

Question 23

First Generation Fluoroquinolones

Answer 23

Nalidixic acid, Cinaxacin, Rosoxacin

Question 24

Second Generation Fluoroquinolones

Answer 24

Ciprofloxacin, Ofloxacin, Norfloxacin

Question 25

Third Generation Fluoroquinolones

Answer 25

Levofloxacin, Sparfloxacin, Grepafloxacin

Question 26

Fourth Generation Fluoroquinolones

Answer 26

Moxifloxacin, Trovafloxacin, Gemifloxacin, Gatifloxacin

Question 27

Fluoroquinolones withdrawn from market

Answer 27

Grepafloxacin and Gatifloxacin

Question 28

First generation quinolone hypothetical clinical use

Answer 28

UTI

Question 29

Second generation quinolone use

Answer 29

Gram (-) cocci, Gram (+) cocci | Mycoplasma

Question 30

Third generation quinolone use

Answer 30

Gram (+) > Gram (-) | Streptococci, Enterococci

Question 31

Fourth generation quinolone use

Answer 31

Broad spectrum - Anaerobes

Question 32

Side effect of Fluoroquinolone

Answer 32

Tendinitis and Tendon rupture

Question 33

Contraindication of Ciprofloxacin and Levofloxacin

Answer 33

Children and Pregnant

Question 34

Grepafloxin side effect

Answer 34

Severe cardiotoxicity

Question 35

Fluoroquinone causing Diabetes

Answer 35

Gatifloxacin

Question 36

Hepatotoxic fluoroquinone

Answer 36

Trovafloxacin

Question 37

Potentiated by Fluoroquinone

Answer 37

Methylxanthines

Question 38

Nitroimidazole drugs

Answer 38

Metronidazole, Tinidazole

Question 39

Antiprotozoal drug

Answer 39

Metronidazole

Question 40

Metronidazole MOA

Answer 40

Reduce ferredoxin forming free radicals that disrupt ETC

Question 41

Metronidazole use

Answer 41

Anaerobic infections below the diaphragm Vaginitis Pseudomembranous colitis

Question 42

Nitrofuran drug

Answer 42

Nitrofurantoin

Question 43

Forms multiple reactive intermediates when acted upon by bacterial nitrofuran reductase

Answer 43

Nitrofurantoin

Question 44

Nitrofurantoin indication

Answer 44

UTI except | Proteus and Pseudomonas

Question 45

Pulmonary Fibrosis Drugs

Answer 45

Bleomycin, Busulfan, Bromocriptine, Amiodarone, Nitrofurantoin, Methotrexate