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Pharmacology > Anti-Fungal Drugs > Flashcards

Anti-Fungal Drugs Flashcards

1
Q

Binds to ergosterol in fungal cell membranes forming artificial pores

A

Amphotericin B and Nystatin

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2
Q

Polyene antifungal

A

Amphotericin B

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3
Q

Fungicidal antimycotic

A

Amphotericin B, Terbinafine, Nystatin

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4
Q

Fungistatic antimycotic

A

Flucytosine, Caspofungin, Griseofulvin, AZOLEs

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5
Q

Systemic fungal infections DOC

A

Amphotericin B

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6
Q

Side effect of Amphotericin B

A 
Renal Tubular Acidosis
Infusion reactions (treat with antihistamines)
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7
Q

Pyrimidine antimetabolite

A

Flucytosine

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8
Q

Antimycotic which inhibits thimidylate snythase by action of permease in fungal cells

A

Flucytosine

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9
Q

Systemic candidal infection
Chromoblastomycosis (Madura foot)
Cryptococcus

A

Flucytosine

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10
Q

Blocks fungal P450-dependent enzymes stopping ergosterol synthesis

A

Ketoconazole, Fluconazole, Itraconazole, Clotrimazole

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11
Q

Narrow antifungal spectrum

A

Ketoconazole

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12
Q

Ketoconazole route of administration

A

Topical only

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13
Q

Cryptococcus treatment and prophylaxis

A

Fluconazole

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14
Q

Sporotrichosis

A

Itraconazole

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15
Q

Inhibits B-glucan synthase decreasing fungal cell wall synthesis

A

Caspofungin

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16
Q

Echinocandin antifungal

A

Caspofungin, Micafungin, Anidulafungin

17
Q

Disseminated and mucocutaneous candidiasis

A

Caspofungin

18
Q

Salvage therapy for invasive aspergillosis

A

Caspofungin

19
Q

Interferes with microtubule function and inhibits synthesis and polymerization of nucleic acids

A

Griseofulvin

20
Q

Dermatophytosis use only

A

Griseofulvin

21
Q

Systemic antifungal that accumulates in keratin

A

Griseofulvin, Terbinafine

22
Q

Griseofulvin contraindication

A

porphyria

23
Q

Squalene oxidase inhibitor

A

Terbinafine

24
Q

Onychomycosis

A

Terbinafine

25
Q

Oral, Esophageal, Vaginal candidiasis DOC

A

Nystatin

26
Q

Nystatin side effect

A

SEVERE nephrotoxicity

27
Q

Swish and Swallow

A

Nystatin

28
Q

Ptyriasis versicolor

A

Clotrimazole

29
Q

Spaghetti and Meatball appearance

A

Malasezzia furfur

Pharmacology (31 decks)

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