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Pharmacology > Anti-Malarial Drugs > Flashcards

Anti-Malarial Drugs Flashcards

0
Q

Kills schizonts in erythrocytes

A

Blood schizonticide

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1
Q

Kills liver schizonts or hypnozoites

A

Tissue schizonticide

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2
Q

Kills gametes in human blood

A

Gametocide

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3
Q

Prevent sporogony and multiplication in vector

A

Sporonticide

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4
Q

Dormant liver hypnozoites

A

P. vivax, P. ovale

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5
Q

Pigment of malaria

A

Hemozoin

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6
Q

Chloroquine MOA

A

Prevents polymerization of heme to hemozoin

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7
Q

Blood schizonticide

A

Chloroquine, Quinine, Mefloquine, Doxycycline, Lumefantrine, Artemisinin

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8
Q

Blood and Tissue schizonticide

A

Primaquine, Atovaquone

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9
Q

Non-falciparum chloroquine-sensitive malaria DOC

A

Chloroquine

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10
Q

Non-falciparum chloroquine-sensitive malaria prophylaxis

A

Chloroquine

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11
Q

chloroquine-resistant malaria DOC

A

Quinidine

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12
Q

chloroquine-resistant malaria prophylaxis

A

Mefloquine

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13
Q

Malaria DOC in pregnant

A

Quinidine

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14
Q

Severe falciparum Malaria DOC

A

Quinidine

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15
Q

Non-severe falciparum Malaria DOC

A

Co-Artem (Artemisinin + Lumefantrine)

16
Q

Vivax and Ovale DOC for treatment

A

Primaquine

17
Q

Vivax and Ovale DOC for prophylaxis

A

Primaquine

18
Q

Blackwater fever

19
Q

Quinine MOA

A

Block DNA replication and transcription

20
Q

Primaquine MOA

A

Forms redox compounds that acts as cellular oxidants

21
Q

Target of primaquine

A

Liver hypnozoites

22
Q

Liver hypnozoite sequela

23
Q

Anti-malarial that disrupts mitochondrial ETC

A

Atovaquone

24
Q

Malarone

A

Atovaquone-Proguanil

25
Q

Second line chloroquine-resistant malaria prophylaxis

26
Q

Multidrug-resistant malaria prophylaxis

A

Doxycycline

Pharmacology (31 decks)

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