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Pharmacology > Local Anesthetics > Flashcards

Local Anesthetics Flashcards

0
Q

Route of administration of local anesthetics

A

Topical or Intramuscular

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1
Q

Blockage of sensory transmission from local area of the body to the CNS

A

Local Anesthesia

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2
Q

Amide or Ester:

Tetracaine

A

Ester

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3
Q

Amide or Ester:

Procaine

A

Ester

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4
Q

Amide or Ester:

Benzocaine

A

Ester

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5
Q

Amide or Ester:

Cocaine

A

Ester

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6
Q

Amide or Ester:

Bupivacaine

A

Amide

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7
Q

Amide or Ester:

Ropivacaine

A

Amide

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8
Q

Amide or Ester:

Lidocaine

A

Amide

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9
Q

Local anesthetic with shortest half life

A

Procaine

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10
Q

Local anesthetic with longest half life

A

Ropivacaine

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11
Q

Local anesthetic MOA

A

Na channel, voltage gated, blocked

Prevents depolarization

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12
Q

T/F: Local anesthetics are weak acids

A

False. Local anesthetics are weake bases that undergo dissociation

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13
Q

State-dependent blockade of ion channels

A

Activated state > Inactivated state > Resting state

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14
Q

Use-dependent blockade of ion channels

A

Rapidly firing > Slow firing

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15
Q

Electrolyte abnormality that enhances local anesthetic activity

A

Hyperkalemia

16
Q

Electrolyte abnormality that antagonize local anesthetic activity

A

Hypercalcemia

17
Q

All local anesthetics are vasodilators except:

A

Cocaine (vasoconstrictor)

18
Q

Procaine SimD

A

Novocaine

19
Q

Benzocaine SimD

A

Butamben

20
Q

Additional and unique MOA of Cocaine

A

Intrinsic sympathomimetic activity

21
Q

Local anesthetic that is a drug of abuse

A

Cocaine

22
Q

Other uses of Tetracaine aside from local anesthesia

A

Epidural anesthesia, Spinal anesthesia, Ophthalmic anesthesia

23
Q

Local anesthesia with antiarryhthmic effects

A

Lidocaine

24
Q

Toxic side effect of Lidocaine

A

Seizures

25
Q

Normal dose of Lidocaine

A

5 mg/kg

26
Q

Local anesthetic used for dental procedures

A

Prilocaine

27
Q

Dreaded side effect of local anesthetic used for dental procedures

A

Methemoglobinemia (Prilocaine)

28
Q

Other uses of Bupivacaine aside from local anesthesia

A

Epidural anesthesia, Intrathecal anesthesia

29
Q

Anesthetics which cause antibody formation

A

Local anesthesia

30
Q

Local amide anesthetic which cause severe cardiotoxicitiy

A

Bupivacaine and Ropivacaine

31
Q

Treatment for local anesthetic induced cardiotoxicity

A

Intralipid - fat emulsion (used in TPN)

SE of Bupivacaine and Ropivacaine

32
Q

Local anesthetic contraindicated in intravenous local anesthesia

A

Bupivacaine and Ropivacaine

33
Q

Other use of Ropivacaine aside from local anesthesia

A

Epidural anesthesia

Pharmacology (31 decks)

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