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Pharmacology > Antipsychotics > Flashcards

Antipsychotics Flashcards

0
Q

Atypical antipsychotics

A

Heterocyclics (-pine, -done, -azole)
Clozapine, Olanzapine, Loxapine, Quetiapine
Risperidone, Ziprasidone
Aripiprazole

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1
Q

Typical antipsychotics

A

Phenothiazine (-azine)
Butyrophenone (haloperidol)
Thioxanthene (thiothixene)

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2
Q

Typical antipsychotic with less EPS but more H1, a1 and muscarinic blockade

A

Low potency

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3
Q

Typical antipsychotic with more EPS but less H1, a1 and muscarinic blockade

A

High potency

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4
Q

Blockade of what dopaminergic receptor is correlated with EPS

A

D2

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5
Q

Location of D2 receptors

A

Caudate, Putamen, Nucleus accumbens, Cortex, Hypothalamus

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6
Q

Dopaminergic tracts associated with schizophrenia

A

Mesocortical-Mesolimbic
Nigrostriatal
Tuberoinfundibular

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7
Q

Treats positive symptoms of schizophrenia

A

Typical and Atypical antipsychotic

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8
Q

Treats negative symptoms of schizophrenia

A

Atypical antipsychotics

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9
Q

Endocrinologic effect of dopamine receptor blockade

A

Hyperprolactinemia

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10
Q

Acute dystonia DOC

A

Diphenhydramine

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11
Q

Parkinsonism DOC

A

Benztropine

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12
Q

Rabbit Syndrome DOC

A

Benztropine

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13
Q

Neuroleptic Malignant Syndrome DOC

A

Dantrolene

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14
Q

Typical antipsychotic MOA

A

Blocks D2 receptors&raquo_space; 5HT receptors

Alpha 1 adrenoreceptor blockade

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15
Q

Atypical antipsychotic MOA

A

Blocks 5HT receptors&raquo_space; D2 receptors

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16
Q

Antipsychotic which causes neuroleptic malignant syndrome

A

Chlorpromazine and Haloperidol

17
Q

Corneal and lens deposits seen in patients receiving which antipsychotic

A

Chlorpromazine only

18
Q

Antipsychotic used as antiemetic

A

Prochlorperazine

19
Q

Retinal deposits seen in patients receiving which antipsychotic

A

Thioridazine and all other phenothiazine

20
Q

Antipsychotic with fatal overdose

A

Thioridazine

21
Q

Antipsychotic with strongest autonomic effects

A

Thioridazine

22
Q

Antipsychotic used for Tourette syndrome

A

Haloperidol or Risperidone

23
Q

Antipsychotic used for Huntington’s disease

A

Haloperidol

24
Q

Antipsychotic with weakest autonomic effect

A

Haloperidol

25
Q

Antipsychotic that reduces suicide risk in schizophrenics

A

Clozapine

26
Q

Antipsychotic causing marked weight gain, hyperlopodemis, hyperglycemia

A

Olanzapine

27
Q

Antipsychotic drug for anorexia nervosa

A

Olanzapine

28
Q

Quetiapine side effects

A

Somnolence, sleep paralysis, hypnagogic hallucinations and priapism

29
Q

Antipsychotic for youth schizophrenia

A

Risperidone

30
Q

Antipsychotic for intractable hiccups

A

Risperidone

31
Q

Antipsychotic causing photosensitivity

A

Risperidone

32
Q

Antipsychotic causing QT prolongation

A

Ziprasidone

33
Q

Least sedating typical antipsychotic

A

Haloperidol

34
Q

Least sedating atypical antipsychotic

A

Aripiprazole

35
Q

Patient on Chlorpromazine develops fever, unstable VS, rigidity and disorientation. Labs show elevated CPK. DOC?

A

Dantrolene (neuroleptic malignant syndrome)

36
Q

Bipolar Disorder DOC

A

Lithium

37
Q

T/F: antidepressant monotherapy is the DOC for bipolar disorder

A

False. Antidepressant + Lithium (manic episodes)

38
Q

Mood stabilizer contraindicated in sick sinus syndrome

A

Lithium

39
Q

Teratogenic effect of Lithium

A

Ebstein anomaly

40
Q

Lithium overdose treatment

A

Hemodialysis

41
Q

Toxicity threshold for Lithium

A

2 meq/L

Pharmacology (31 decks)

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