Antipsychotics

Question 0

Atypical antipsychotics

Answer 0

Heterocyclics (-pine, -done, -azole)
Clozapine, Olanzapine, Loxapine, Quetiapine
Risperidone, Ziprasidone
Aripiprazole

Question 1

Typical antipsychotics

Answer 1

Phenothiazine (-azine)
Butyrophenone (haloperidol)
Thioxanthene (thiothixene)

Question 2

Typical antipsychotic with less EPS but more H1, a1 and muscarinic blockade

Answer 2

Low potency

Question 3

Typical antipsychotic with more EPS but less H1, a1 and muscarinic blockade

Answer 3

High potency

Question 4

Blockade of what dopaminergic receptor is correlated with EPS

Answer 4

D2

Question 5

Location of D2 receptors

Answer 5

Caudate, Putamen, Nucleus accumbens, Cortex, Hypothalamus

Question 6

Dopaminergic tracts associated with schizophrenia

Answer 6

Mesocortical-Mesolimbic
Nigrostriatal
Tuberoinfundibular

Question 7

Treats positive symptoms of schizophrenia

Answer 7

Typical and Atypical antipsychotic

Question 8

Treats negative symptoms of schizophrenia

Answer 8

Atypical antipsychotics

Question 9

Endocrinologic effect of dopamine receptor blockade

Answer 9

Hyperprolactinemia

Question 10

Acute dystonia DOC

Answer 10

Diphenhydramine

Question 11

Parkinsonism DOC

Answer 11

Benztropine

Question 12

Rabbit Syndrome DOC

Answer 12

Benztropine

Question 13

Neuroleptic Malignant Syndrome DOC

Answer 13

Dantrolene

Question 14

Typical antipsychotic MOA

Answer 14

Blocks D2 receptors&raquo_space; 5HT receptors

Alpha 1 adrenoreceptor blockade

Question 15

Atypical antipsychotic MOA

Answer 15

Blocks 5HT receptors&raquo_space; D2 receptors

Question 16

Antipsychotic which causes neuroleptic malignant syndrome

Answer 16

Chlorpromazine and Haloperidol

Question 17

Corneal and lens deposits seen in patients receiving which antipsychotic

Answer 17

Chlorpromazine only

Question 18

Antipsychotic used as antiemetic

Answer 18

Prochlorperazine

Question 19

Retinal deposits seen in patients receiving which antipsychotic

Answer 19

Thioridazine and all other phenothiazine

Question 20

Antipsychotic with fatal overdose

Answer 20

Thioridazine

Question 21

Antipsychotic with strongest autonomic effects

Answer 21

Thioridazine

Question 22

Antipsychotic used for Tourette syndrome

Answer 22

Haloperidol or Risperidone

Question 23

Antipsychotic used for Huntington’s disease

Answer 23

Haloperidol

Question 24

Antipsychotic with weakest autonomic effect

Answer 24

Haloperidol

Question 25

Antipsychotic that reduces suicide risk in schizophrenics

Answer 25

Clozapine

Question 26

Antipsychotic causing marked weight gain, hyperlopodemis, hyperglycemia

Answer 26

Olanzapine

Question 27

Antipsychotic drug for anorexia nervosa

Answer 27

Olanzapine

Question 28

Quetiapine side effects

Answer 28

Somnolence, sleep paralysis, hypnagogic hallucinations and priapism

Question 29

Antipsychotic for youth schizophrenia

Answer 29

Risperidone

Question 30

Antipsychotic for intractable hiccups

Answer 30

Risperidone

Question 31

Antipsychotic causing photosensitivity

Answer 31

Risperidone

Question 32

Antipsychotic causing QT prolongation

Answer 32

Ziprasidone

Question 33

Least sedating typical antipsychotic

Answer 33

Haloperidol

Question 34

Least sedating atypical antipsychotic

Answer 34

Aripiprazole

Question 35

Patient on Chlorpromazine develops fever, unstable VS, rigidity and disorientation. Labs show elevated CPK. DOC?

Answer 35

Dantrolene (neuroleptic malignant syndrome)

Question 36

Bipolar Disorder DOC

Answer 36

Lithium

Question 37

T/F: antidepressant monotherapy is the DOC for bipolar disorder

Answer 37

False. Antidepressant + Lithium (manic episodes)

Question 38

Mood stabilizer contraindicated in sick sinus syndrome

Answer 38

Lithium

Question 39

Teratogenic effect of Lithium

Answer 39

Ebstein anomaly

Question 40

Lithium overdose treatment

Answer 40

Hemodialysis

Question 41

Toxicity threshold for Lithium

Answer 41

2 meq/L