Anti-Parkinson's Disease

Question 0

Primary signs of Parkinson’s Disease

Answer 0

Tremors, Rigidity, Akinesia, Postural instability

Question 1

Site of degeneration of dopaminergic neurons in paralysis agitans

Answer 1

Substantia nigra

Question 2

Drugs that induce Parkinsonism

Answer 2

Typical antipsychotics, Reserpine, MPTP

Question 3

Peripheral metabolism of Levodopa

Answer 3

COMT to become 3-OMD

DOPA decarboxylase to become Dopamine

Question 4

Central metabolism of Levodopa

Answer 4

DOPA decarboxylase to Dopamine

Question 5

Central metabolism of Dopamine

Answer 5

MAO-B to DOPAC

COMT to 3-OMD

Question 6

Toxic metabolites of Levodopa peripherally

Answer 6

3-OMD and dopamine

Question 7

Toxic metabolites of Dopamine centrally

Answer 7

3-OMD and DOPAC

Question 8

Inhibits peripheral DOPA decarboxylase

Answer 8

Levodopa-Carbidopa

Question 9

Primary drug for Parkinson’s disease

Answer 9

Levodopa-Carbidopa

Question 10

Levodopa-Carbidopa side effect:

Alternating periods of improved mobility and akinesia during treatment

Answer 10

On and Off Phenomenon

Question 11

Levodopa-Carbidopa side effect:

Deterioration of drug effect in between medication doses

Answer 11

Wearing Off Phenomenon

Question 12

Contraindication of Levodopa-Carbidopa

Answer 12

Psychosis

Question 13

Levodopa-Carbidopa + MAO-B inhibitor

Answer 13

Hypertensive crisis

Question 14

Treatment for on and off phenomenon

Answer 14

Apomorphine

Question 15

Treatment for wearing off phenomenon

Answer 15

Entacapone

Question 16

Intermittent occlusion of vessels in the upper snd lower extremities causing burning pain

Answer 16

Erythromelalgia

Question 17

Drugs that cause erythromelalgia

Answer 17

Bromocriptine, Pergolide

Question 18

Bromocriptine SimD

Answer 18

Pergolide

Question 19

Bromocriptine MOA

Answer 19

Partial agonist at Dopamine D2 receptors

Question 20

Pramipexole SimD

Answer 20

Ropinirole

Question 21

Pramipexole MOA

Answer 21

Partial agonist at Dopamine D3 receptors

Question 22

DOC for restless leg syndrome

Answer 22

Pramipexole

Question 23

Side effect of pramipexole

Answer 23

Compulsive gambling, hypersexuality, overeating, narcolepsy

Question 24

Pramipexole contraindications

Answer 24

Psychosis, PUD, MI

Question 25

Apomorphine MOA

Answer 25

Partial agonist at Dopamine D3 receptors 5HT receptor antagonist Alpha adrenoreceptor antagonist

Question 26

Side effect of Apomorphine

Answer 26

Severe nausea

Question 27

Preatment to avoid severe side effect of Apomorphine

Answer 27

Trimethobenzamide (to prevent severe nausea)

Question 28

MAO-B inhibitor

Answer 28

Selegiline, Rasagiline

Question 29

Selegiline + Meperidine

Answer 29

Fatal reaction - agitation, delirium, death

Question 30

Selegiline + SSRI

Answer 30

Serotonin Syndrome

Question 31

Entacapone MOA

Answer 31

COMT inhibitor

Question 32

Anti-parkinsons that cause orange urine

Answer 32

Entacapone

Question 33

Drug that increase response to levodopa

Answer 33

MAO-B inhibitor

Question 34

Drug that prolongs response to levodopa

Answer 34

COMT inhibitor

Question 35

Anti-Parkinson's drug that caused neuroleptic malignant syndrome

Answer 35

Entacapone

Question 36

An antiviral anti-parkison's drug

Answer 36

Amantadine

Question 37

Amantadine: Influenza __ Oseltamivir: Influenza __

Answer 37

Amantadine: Influenza A Oseltamivir: Influenza A, B

Question 38

Livedo Reticularis drugs

Answer 38

Amantadine Hydroxyurea Minocycline Gemcitabine Quinidine

Question 39

Amantadine MOA

Answer 39

Dopaminergic, potentiated dopamine synthesis, release and reuptake

Question 40

Benztropine MOA

Answer 40

Muscarinic blocker

Question 41

Benztropine SimD

Answer 41

Biperiden, Trihrxyphendiyl, Orphenadrine

Question 42

Amantadine target symptoms

Answer 42

Tremors, Rigidity, Akinesia

Question 43

Benztropine twrget symptoms

Answer 43

Tremors, Rigidity