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Pharmacology > Anti-Parkinson's Disease > Flashcards

Anti-Parkinson's Disease Flashcards

0
Q

Primary signs of Parkinson’s Disease

A

Tremors, Rigidity, Akinesia, Postural instability

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1
Q

Site of degeneration of dopaminergic neurons in paralysis agitans

A

Substantia nigra

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2
Q

Drugs that induce Parkinsonism

A

Typical antipsychotics, Reserpine, MPTP

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3
Q

Peripheral metabolism of Levodopa

A

COMT to become 3-OMD

DOPA decarboxylase to become Dopamine

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4
Q

Central metabolism of Levodopa

A

DOPA decarboxylase to Dopamine

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5
Q

Central metabolism of Dopamine

A

MAO-B to DOPAC

COMT to 3-OMD

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6
Q

Toxic metabolites of Levodopa peripherally

A

3-OMD and dopamine

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7
Q

Toxic metabolites of Dopamine centrally

A

3-OMD and DOPAC

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8
Q

Inhibits peripheral DOPA decarboxylase

A

Levodopa-Carbidopa

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9
Q

Primary drug for Parkinson’s disease

A

Levodopa-Carbidopa

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10
Q

Levodopa-Carbidopa side effect:

Alternating periods of improved mobility and akinesia during treatment

A

On and Off Phenomenon

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11
Q

Levodopa-Carbidopa side effect:

Deterioration of drug effect in between medication doses

A

Wearing Off Phenomenon

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12
Q

Contraindication of Levodopa-Carbidopa

A

Psychosis

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13
Q

Levodopa-Carbidopa + MAO-B inhibitor

A

Hypertensive crisis

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14
Q

Treatment for on and off phenomenon

A

Apomorphine

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15
Q

Treatment for wearing off phenomenon

A

Entacapone

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16
Q

Intermittent occlusion of vessels in the upper snd lower extremities causing burning pain

A

Erythromelalgia

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17
Q

Drugs that cause erythromelalgia

A

Bromocriptine, Pergolide

18
Q

Bromocriptine SimD

A

Pergolide

19
Q

Bromocriptine MOA

A

Partial agonist at Dopamine D2 receptors

20
Q

Pramipexole SimD

A

Ropinirole

21
Q

Pramipexole MOA

A

Partial agonist at Dopamine D3 receptors

22
Q

DOC for restless leg syndrome

A

Pramipexole

23
Q

Side effect of pramipexole

A

Compulsive gambling, hypersexuality, overeating, narcolepsy

24
Q

Pramipexole contraindications

A

Psychosis, PUD, MI

25
Q

Apomorphine MOA

A

Partial agonist at Dopamine D3 receptors
5HT receptor antagonist
Alpha adrenoreceptor antagonist

26
Q

Side effect of Apomorphine

A

Severe nausea

27
Q

Preatment to avoid severe side effect of Apomorphine

A

Trimethobenzamide (to prevent severe nausea)

28
Q

MAO-B inhibitor

A

Selegiline, Rasagiline

29
Q

Selegiline + Meperidine

A

Fatal reaction - agitation, delirium, death

30
Q

Selegiline + SSRI

A

Serotonin Syndrome

31
Q

Entacapone MOA

A

COMT inhibitor

32
Q

Anti-parkinsons that cause orange urine

A

Entacapone

33
Q

Drug that increase response to levodopa

A

MAO-B inhibitor

34
Q

Drug that prolongs response to levodopa

A

COMT inhibitor

35
Q

Anti-Parkinson’s drug that caused neuroleptic malignant syndrome

A

Entacapone

36
Q

An antiviral anti-parkison’s drug

A

Amantadine

37
Q

Amantadine: Influenza __
Oseltamivir: Influenza __

A

Amantadine: Influenza A
Oseltamivir: Influenza A, B

38
Q

Livedo Reticularis drugs

A

Amantadine Hydroxyurea
Minocycline Gemcitabine
Quinidine

39
Q

Amantadine MOA

A

Dopaminergic, potentiated dopamine synthesis, release and reuptake

40
Q

Benztropine MOA

A

Muscarinic blocker

41
Q

Benztropine SimD

A

Biperiden, Trihrxyphendiyl, Orphenadrine

42
Q

Amantadine target symptoms

A

Tremors, Rigidity, Akinesia

43
Q

Benztropine twrget symptoms

A

Tremors, Rigidity

Pharmacology (31 decks)

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