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Antiviral Drugs Flashcards

1
Q

Herpes

A

Acyclovir

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2
Q

Acyclovir SimD

A

Valacyclovir, Penciclovir, Famciclovir, Docosanol

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3
Q

Activated by viral thymidine kinase to forms that inhibit viral DNA polymerase

A

Acyclovir

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4
Q

T/F: Acyclovir acts on strains of HSV even without thymidine kinase

A

False. Acyclovir act on strains of HSV WITH thymidine kinase

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5
Q

Inhibits HSV envelope fusion with plasma membranes

A

Docosanol

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6
Q

Inhibits viral DNA polymerase causing chain termination

A

Ganciclovir, Valganciclovir

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7
Q

CMV

A

Ganciclovir

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8
Q

Ganciclovir use

A

CMV, HSV, VZV

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9
Q

T/F: Ganciclovir acts on strains of HSV even without thymidine kinase

A

False. Ganciclovir act on strains of HSV WITH thymidine kinase

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10
Q

T/F: Cifodivir acts on strains of HSV even without thymidine kinase

A

True

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11
Q

CMV retinitis

A

Cifodivir, Foscarnet

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12
Q

Acyclovir-resistance

A

Cifodivir, Foscarnet

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13
Q

Ganciclovir-resistance

A

Cifodivir

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14
Q

Mucocutaneous HSV infection

A

Cifodivir

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15
Q

Molluscum contagiosum

A

Cifodivir

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16
Q

T/F: Foscarnet acts on strains of HSV even without thymidine kinase

A

True

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17
Q

AIDS with HSV

A

Forscarnet

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18
Q

Pyrophosphate analog

A

Foscarnet

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19
Q

Highly Active Antiretroviral Therapy drug combination

A

2 NRTI + 1 protease inhibitor

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20
Q

Nucleoside Reverse Transcriptase Inhibitor

A

Zidovudine

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21
Q

Non-nucleoside Reverse Transcriptase Inhibitor

A

Delavirdine, Efavirenz, Etravirine, Evirapine (E-VIR)

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22
Q

Inhibits HIV reverse transcriptase after phosphorylation by cellular enzymes

A

Nucleoside Reverse Transcriptase Inhibitor

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23
Q

Inhibits HIV reverse transcriptase with NO Phosphorylation

A

Non-nucleoside Reverse Transcriptase Inhibitor

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24
Q

Prevention of HIV vertical transmission

A

Nucleoside Reverse Transcriptase Inhibitor

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25
Side effect of NRTI
Lactic acidosis with Hepatic steatosis
26
Zidovudine side effect
Bone marrow suppression
27
Abacavir side effect
Hypersensitivity
28
Didanosine side effect
Acute pancreatitis
29
Stavudine, Zalcitabine side effect
Peripheral neuropathy
30
Delavirdine, Nevirapine side effect
Rash and elevated AST/ALT
31
Efavirenz side effect
Teratogenic
32
Etraverin
Elevated cholesterol and triglycerides
33
Anti-HIV drugs that exhibit cross reaction
NNRTI
34
Anti-HIV drugs that does not exhibit cross reaction
NRTI
35
Protease inhibitor MOA
Inhibit viral protein processing
36
Protease inhibitor
Indinavir (-NAVIR)
37
Side effect of protease inhibitors
Metabolic syndrome - acanthosis nigricans, hyperlipidemia, fat redistribution, hyperglycemia, insulin resistance
38
Atazanavir side effect
peripheral neuropathy
39
Amprenavir side effect
rash
40
Indinavir side effect
Hyperbilirubinemia and Nephrolithiasis
41
Atazanavir, Fosamprenavir, Lopinavir, Nelfinavir, Saquinavir
GI distress and diarrhea
42
Binds to gp41 subunit of viral envelope glycoprotein preventing fusion of viral and cellular membranes
Enfuvirtide
43
Enfuvirtide side effect
Bacterial pneumonia
44
Blocks viral attachment via transmembrane chemokine receptor CCR5
Maraviroc
45
CCR5 receptor antagonist
Maraviroc
46
Influenza A
Amantadine, Rimandatine, Oseltamivir, Zanamivir
47
Influenza B
Oseltamivir, Zanamivir
48
Rubella
Amantandine
49
Inhibit early step replication and prevent uncoating by binding to M2 proton channels
Amantadine
50
Medium-sized vasculitis caused by Amantadine
Livedo reticularis
51
Obsolete Influenza treatment
Amantadine
52
Inhibits neuraminidase and decreases release of progeny virus
Oseltamivir
53
Effect of Oseltamivir on Influenza
Shorten duration of symptoms
54
Oseltamivir side effect
Gastrointestinal effects
55
Zanamivir side effect
Bronchospasm in asthma
56
AH1N1 DOC
Oseltamivir
57
Influenza DOC
Oseltamivir
58
Degrades viral RNA via activation of host cell RNAse
Interferon Alfa
59
Interferon Alfa use
HBV, HCV, Kaposi sarcoma, Genital warts
60
Contraindications of Interferon Alfa
Autoimmune disease Cardiac Arryhthmia Pregnancy
61
Inhibits HBV DNA polymerase
Lamivudine
62
T/F: Coinfection between HBV and HIV may increase the risk of pancreatitis with lamivudine use
True
63
HBV DOC
Interferon Alfa + Lamivudine
64
HCV DOC
Interferon Alfa + Ribavirin
65
Inhibits guanosine triphosphate formation Prevent viral mRNA capping Blocks RNA polymerase
Ribavirin
66
IV drug administered early that decreases mortality in viral hemorrhagic fevers
Ribavirin
67
West Nile and Ebola Virus
Ribavirin

Pharmacology (31 decks)

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