Antiviral Drugs Flashcards
Herpes
Acyclovir
Acyclovir SimD
Valacyclovir, Penciclovir, Famciclovir, Docosanol
Activated by viral thymidine kinase to forms that inhibit viral DNA polymerase
Acyclovir
T/F: Acyclovir acts on strains of HSV even without thymidine kinase
False. Acyclovir act on strains of HSV WITH thymidine kinase
Inhibits HSV envelope fusion with plasma membranes
Docosanol
Inhibits viral DNA polymerase causing chain termination
Ganciclovir, Valganciclovir
CMV
Ganciclovir
Ganciclovir use
CMV, HSV, VZV
T/F: Ganciclovir acts on strains of HSV even without thymidine kinase
False. Ganciclovir act on strains of HSV WITH thymidine kinase
T/F: Cifodivir acts on strains of HSV even without thymidine kinase
True
CMV retinitis
Cifodivir, Foscarnet
Acyclovir-resistance
Cifodivir, Foscarnet
Ganciclovir-resistance
Cifodivir
Mucocutaneous HSV infection
Cifodivir
Molluscum contagiosum
Cifodivir
T/F: Foscarnet acts on strains of HSV even without thymidine kinase
True
AIDS with HSV
Forscarnet
Pyrophosphate analog
Foscarnet
Highly Active Antiretroviral Therapy drug combination
2 NRTI + 1 protease inhibitor
Nucleoside Reverse Transcriptase Inhibitor
Zidovudine
Non-nucleoside Reverse Transcriptase Inhibitor
Delavirdine, Efavirenz, Etravirine, Evirapine (E-VIR)
Inhibits HIV reverse transcriptase after phosphorylation by cellular enzymes
Nucleoside Reverse Transcriptase Inhibitor
Inhibits HIV reverse transcriptase with NO Phosphorylation
Non-nucleoside Reverse Transcriptase Inhibitor
Prevention of HIV vertical transmission
Nucleoside Reverse Transcriptase Inhibitor
Side effect of NRTI
Lactic acidosis with Hepatic steatosis
Zidovudine side effect
Bone marrow suppression