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Pharmacology > Antiviral Drugs > Flashcards

Antiviral Drugs Flashcards

1
Q

Herpes

A

Acyclovir

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2
Q

Acyclovir SimD

A

Valacyclovir, Penciclovir, Famciclovir, Docosanol

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3
Q

Activated by viral thymidine kinase to forms that inhibit viral DNA polymerase

A

Acyclovir

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4
Q

T/F: Acyclovir acts on strains of HSV even without thymidine kinase

A

False. Acyclovir act on strains of HSV WITH thymidine kinase

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5
Q

Inhibits HSV envelope fusion with plasma membranes

A

Docosanol

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6
Q

Inhibits viral DNA polymerase causing chain termination

A

Ganciclovir, Valganciclovir

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7
Q

CMV

A

Ganciclovir

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8
Q

Ganciclovir use

A

CMV, HSV, VZV

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9
Q

T/F: Ganciclovir acts on strains of HSV even without thymidine kinase

A

False. Ganciclovir act on strains of HSV WITH thymidine kinase

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10
Q

T/F: Cifodivir acts on strains of HSV even without thymidine kinase

A

True

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11
Q

CMV retinitis

A

Cifodivir, Foscarnet

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12
Q

Acyclovir-resistance

A

Cifodivir, Foscarnet

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13
Q

Ganciclovir-resistance

A

Cifodivir

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14
Q

Mucocutaneous HSV infection

A

Cifodivir

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15
Q

Molluscum contagiosum

A

Cifodivir

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16
Q

T/F: Foscarnet acts on strains of HSV even without thymidine kinase

A

True

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17
Q

AIDS with HSV

A

Forscarnet

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18
Q

Pyrophosphate analog

A

Foscarnet

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19
Q

Highly Active Antiretroviral Therapy drug combination

A

2 NRTI + 1 protease inhibitor

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20
Q

Nucleoside Reverse Transcriptase Inhibitor

A

Zidovudine

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21
Q

Non-nucleoside Reverse Transcriptase Inhibitor

A

Delavirdine, Efavirenz, Etravirine, Evirapine (E-VIR)

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22
Q

Inhibits HIV reverse transcriptase after phosphorylation by cellular enzymes

A

Nucleoside Reverse Transcriptase Inhibitor

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23
Q

Inhibits HIV reverse transcriptase with NO Phosphorylation

A

Non-nucleoside Reverse Transcriptase Inhibitor

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24
Q

Prevention of HIV vertical transmission

A

Nucleoside Reverse Transcriptase Inhibitor

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25
Q

Side effect of NRTI

A

Lactic acidosis with Hepatic steatosis

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26
Q

Zidovudine side effect

A

Bone marrow suppression

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27
Q

Abacavir side effect

A

Hypersensitivity

28
Q

Didanosine side effect

A

Acute pancreatitis

29
Q

Stavudine, Zalcitabine side effect

A

Peripheral neuropathy

30
Q

Delavirdine, Nevirapine side effect

A

Rash and elevated AST/ALT

31
Q

Efavirenz side effect

A

Teratogenic

32
Q

Etraverin

A

Elevated cholesterol and triglycerides

33
Q

Anti-HIV drugs that exhibit cross reaction

34
Q

Anti-HIV drugs that does not exhibit cross reaction

35
Q

Protease inhibitor MOA

A

Inhibit viral protein processing

36
Q

Protease inhibitor

A

Indinavir (-NAVIR)

37
Q

Side effect of protease inhibitors

A

Metabolic syndrome - acanthosis nigricans, hyperlipidemia, fat redistribution, hyperglycemia, insulin resistance

38
Q

Atazanavir side effect

A

peripheral neuropathy

39
Q

Amprenavir side effect

40
Q

Indinavir side effect

A

Hyperbilirubinemia and Nephrolithiasis

41
Q

Atazanavir, Fosamprenavir, Lopinavir, Nelfinavir, Saquinavir

A

GI distress and diarrhea

42
Q

Binds to gp41 subunit of viral envelope glycoprotein preventing fusion of viral and cellular membranes

A

Enfuvirtide

43
Q

Enfuvirtide side effect

A

Bacterial pneumonia

44
Q

Blocks viral attachment via transmembrane chemokine receptor CCR5

45
Q

CCR5 receptor antagonist

46
Q

Influenza A

A

Amantadine, Rimandatine, Oseltamivir, Zanamivir

47
Q

Influenza B

A

Oseltamivir, Zanamivir

48
Q

Rubella

A

Amantandine

49
Q

Inhibit early step replication and prevent uncoating by binding to M2 proton channels

A

Amantadine

50
Q

Medium-sized vasculitis caused by Amantadine

A

Livedo reticularis

51
Q

Obsolete Influenza treatment

A

Amantadine

52
Q

Inhibits neuraminidase and decreases release of progeny virus

A

Oseltamivir

53
Q

Effect of Oseltamivir on Influenza

A

Shorten duration of symptoms

54
Q

Oseltamivir side effect

A

Gastrointestinal effects

55
Q

Zanamivir side effect

A

Bronchospasm in asthma

56
Q

AH1N1 DOC

A

Oseltamivir

57
Q

Influenza DOC

A

Oseltamivir

58
Q

Degrades viral RNA via activation of host cell RNAse

A

Interferon Alfa

59
Q

Interferon Alfa use

A

HBV, HCV, Kaposi sarcoma, Genital warts

60
Q

Contraindications of Interferon Alfa

A

Autoimmune disease
Cardiac Arryhthmia
Pregnancy

61
Q

Inhibits HBV DNA polymerase

A

Lamivudine

62
Q

T/F: Coinfection between HBV and HIV may increase the risk of pancreatitis with lamivudine use

63
Q

HBV DOC

A

Interferon Alfa + Lamivudine

64
Q

HCV DOC

A

Interferon Alfa + Ribavirin

65
Q

Inhibits guanosine triphosphate formation
Prevent viral mRNA capping
Blocks RNA polymerase

66
Q

IV drug administered early that decreases mortality in viral hemorrhagic fevers

67
Q

West Nile and Ebola Virus

Pharmacology (31 decks)

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