Thrombosis

Question 1

Thrombosis Definition ?

Answer 1

Formation of solid or semisolid mass from the constituents of blood within the vascular system during life   

Arif Guide-150

Question 2

Thrombus Definition ?

Answer 2

It is a solid or semi solid mass formed from the constituents of streaming blood within the non-interrupted cardiovascular system during life

150

Question 3

Thrombus Classification ?

Answer 3

Venous thrombus
1. Phlebothrombosis
2. Thrombophlebitis
3. Thrombophlebitis migrans
4. Ileofemoral thrombosis

Arterial thrombosis
1. Thrombus in atheromatous plaque -Coronary artery
2. Trauma
3. Atheroma in Abdominal aorta
4. Buerger D

Thrombus in heart
1. Mural thrombosis
2. Vegetations
3. Ball thrombus

page-151

Question 4

Virchow triad-Thrombus Formation ?

Answer 4

1. Endothelial injury
2. Stasis/Turbulent blood flow
3. Hypercoagulable state

152

Question 5

Endothelial injury Mechanism ?

Answer 5

=Endrothelial injury
=exposure of ECM
=Adhesion of platelet
=release of tissue factor
=PGI2
=PAs- Plasminogen activator
=Platelet-Aggregation & Adhesion
=Platelet plug formed
=Thrombus formed

152

Question 6

Endothelial injury example ?

Answer 6

1. MI
2. HTN
3. Smoking
4. Dyslipidemia
5. Homocystinuria
6. Vasculitis
7. Endotoxins

page-152

Question 7

Stasis/Turbulent blood flow ?

Answer 7

T= Arterial & Cardiac thrombus
S= Venous thrombosis

152

Question 8

Stasis/Turbulent blood flow example ??

Answer 8

1. Ulcerated atherosclerotic plaque
2. Sickle cell anemia
3. Polycythemia
4. Mitral stenosis
5. MI Acute

152

Question 9

Hypercoagulable state ??

Answer 9

THROMBI
T=Tissue damage,Trauma
H=Hereditary–Deficiency ATIII Protein-C & S
R=Rest
O=Obsterics–Pregnancy,Eclampsia
M=Malignancy
B=Blood flow disturbance–MI,Varicose vein
I=Immune deficiency – SLE Antiphopholipid AB

PAGE-153

Question 10

Fates of thrombus ??

Answer 10

1. Propagation
2. Embolization
3. Dissolution
4. Organization
5. Recanalization

PEDO R

153

Question 11

Phlebothrombosis Definition ?

Answer 11

Thrombosis in veins having no inflammation is called PT

154

Question 12

Phlebothrombosis examples ??

Answer 12

1. Lower extremities 90%
2. hepatic vein
3. portal vein
4. calf vein
5. ovarian veins
6. periuterine veins

154

Question 13

Pathogenesis of phlebothrombosis ??

Answer 13

1. Primary platelet thrombosis
2. Coralline T- Line of Zahn (NO)
3. Occluding T
4. Consecutive T
5. Propagated T

P—-COC——P

154

Question 14

Phlebothrombosis vs Thrombophlebitis ????????????

Answer 14

1. T=Inflammed vein
2. Main cause= Inflammation
3. Site=Every where
4. Primary Thrombus-Large
5. Propagated thrombus=short /well anchored

154

Question 15

Deep vein thrombosis site ??

Answer 15

1. Femoral V
2. Popliteal V
3. Iliac V

155

Question 16

Common site of thrombus formation ??

Answer 16

Arterial thrombus
1. coronary a
2. cerebral a
3. femoral a

Venous thrombosis
1. calf vein
2. femoral v
3. popliteal v
4. iliac v
5. portal v
6. hepatic v
7. ovarian v
8. periuterine v

155

Question 17

Mural Thrombus ??

Answer 17

Arterial thrombus arise in -=HEART CHAMBER//// aortic lumen
Adhere to the wall of the underlying structure

155

Question 18

Mural thrombi Causes ???

Answer 18

1. MI
2. Atrial fibrillation
3. dilated cardiomyopathy
4. ulcerated athrrosclerotic plaque

Question 19

PostPartum thrombus Possible ??

Answer 19

NO
Thrombus only DURING life

157

Question 20

Thrombus vs Postmortem Clot ???

Answer 20

1. T-dry PPC-Wet+Gelatinous
2. T-Rough surface PPC-Smooth surface
3. T-Hard PPC-Soft
4. T-Line of Zahn Present PPC-NO
5. T-Firmly attached PPC-No attachment
6. T-Friable PPC-Gelatinous

page-157

Question 21

Microscopic feature of thrombi >??

Answer 21

Line of Zhan
marked in cardiac chamber and heart
not well defined in samll artery and vein

page-157