Thrombosis Flashcards
Thrombosis Definition ?
Formation of solid or semisolid mass from the constituents of blood within the vascular system during life
Arif Guide-150
Thrombus Definition ?
It is a solid or semi solid mass formed from the constituents of streaming blood within the non-interrupted cardiovascular system during life
150
Thrombus Classification ?
Venous thrombus
1. Phlebothrombosis
2. Thrombophlebitis
3. Thrombophlebitis migrans
4. Ileofemoral thrombosis
Arterial thrombosis
1. Thrombus in atheromatous plaque -Coronary artery
2. Trauma
3. Atheroma in Abdominal aorta
4. Buerger D
Thrombus in heart
1. Mural thrombosis
2. Vegetations
3. Ball thrombus
page-151
Virchow triad-Thrombus Formation ?
- Endothelial injury
- Stasis/Turbulent blood flow
- Hypercoagulable state
152
Endothelial injury Mechanism ?
=Endrothelial injury
=exposure of ECM
=Adhesion of platelet
=release of tissue factor
=PGI2
=PAs- Plasminogen activator
=Platelet-Aggregation & Adhesion
=Platelet plug formed
=Thrombus formed
152
Endothelial injury example ?
- MI
- HTN
- Smoking
- Dyslipidemia
- Homocystinuria
- Vasculitis
- Endotoxins
page-152
Stasis/Turbulent blood flow ?
T= Arterial & Cardiac thrombus
S= Venous thrombosis
152
Stasis/Turbulent blood flow example ??
- Ulcerated atherosclerotic plaque
- Sickle cell anemia
- Polycythemia
- Mitral stenosis
- MI Acute
152
Hypercoagulable state ??
THROMBI
T=Tissue damage,Trauma
H=Hereditary–Deficiency ATIII Protein-C & S
R=Rest
O=Obsterics–Pregnancy,Eclampsia
M=Malignancy
B=Blood flow disturbance–MI,Varicose vein
I=Immune deficiency – SLE Antiphopholipid AB
PAGE-153
Fates of thrombus ??
- Propagation
- Embolization
- Dissolution
- Organization
- Recanalization
PEDO R
153
Phlebothrombosis Definition ?
Thrombosis in veins having no inflammation is called PT
154
Phlebothrombosis examples ??
- Lower extremities 90%
- hepatic vein
- portal vein
- calf vein
- ovarian veins
- periuterine veins
154
Pathogenesis of phlebothrombosis ??
- Primary platelet thrombosis
- Coralline T- Line of Zahn (NO)
- Occluding T
- Consecutive T
- Propagated T
P—-COC——P
154
Phlebothrombosis vs Thrombophlebitis ????????????
- T=Inflammed vein
- Main cause= Inflammation
- Site=Every where
- Primary Thrombus-Large
- Propagated thrombus=short /well anchored
154
Deep vein thrombosis site ??
- Femoral V
- Popliteal V
- Iliac V
155
Common site of thrombus formation ??
Arterial thrombus
1. coronary a
2. cerebral a
3. femoral a
Venous thrombosis
1. calf vein
2. femoral v
3. popliteal v
4. iliac v
5. portal v
6. hepatic v
7. ovarian v
8. periuterine v
155
Mural Thrombus ??
Arterial thrombus arise in -=HEART CHAMBER//// aortic lumen
Adhere to the wall of the underlying structure
155
Mural thrombi Causes ???
- MI
- Atrial fibrillation
- dilated cardiomyopathy
- ulcerated athrrosclerotic plaque
PostPartum thrombus Possible ??
NO
Thrombus only DURING life
157
Thrombus vs Postmortem Clot ???
- T-dry PPC-Wet+Gelatinous
- T-Rough surface PPC-Smooth surface
- T-Hard PPC-Soft
- T-Line of Zahn Present PPC-NO
- T-Firmly attached PPC-No attachment
- T-Friable PPC-Gelatinous
page-157
Microscopic feature of thrombi >??
Line of Zhan
marked in cardiac chamber and heart
not well defined in samll artery and vein
page-157
