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Pathology-Medical-Prof > Female - Cervix > Flashcards

Female - Cervix Flashcards

1
Q

Pre-malignant lesions of cervix ?

A

1.dysplasia and carcinoma in situ
2.invasive carcinoma

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2
Q

Carcinoma type of cervix ?

A

SCC
adenocarcinoma
adenosquamous Ca
small cell nueroendocrine ca

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3
Q

which one - beshi - in cervical carcinoma ?

A

SCC

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4
Q

Dysplasia type ?

A

CIN-I
CIN-II
CIN-III
Cinsitu

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5
Q

CIN full form ?

A

cervical intra-epithelial neoplasia

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6
Q

CIN category?

A

CIN-1 mild = <1/3
CIN-2 moderate = <2/3 >1/3
CIN-3 severe dysplasia >2/3

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7
Q

SIL full form ?

A

Squamous intra-epithelial lesion

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8
Q

CIN inssitu extent ?

A

full thickness

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9
Q

Low grade SIL ?

A

CIN-1 -Mild

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10
Q

High grade SIL ?

A

CIN-2+3

263

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11
Q

Morphology of CIN ?

A

-cellular immaturity
-cellular disorganization
-nuclear abnormaalities
-inc mitotic activity

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12
Q

high risk SIL which one ?

A

HGSIL

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13
Q

Common virus in SIL ?

A

HPV-16

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14
Q

low risk HPV ?

A

HPV- 6+11

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15
Q

risk factors of carcinoma of cervix ?

A

early age of first intercourse
multiple sexual partner
early first pregnancy
STD
OCP
Cigarette
early first pregnancy

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16
Q

high risk HPV ?

A

HPV-16+18
31 33 35 39 56 58 59 68

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17
Q

Low risk HPV cause ?

A

genital warts +
laryngeal papilloma

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18
Q

genital watrs pathological name ?

A

condyloma acuminata

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19
Q

High risk HPV cause ?

A

high grade CIN
Invasive cervical carcinoma

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20
Q

HPV related protein /

A

E6
E7

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21
Q

Carcinoma in situ feature ?

A

severe dysplasia
diffuse atypia
progressive atypia

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22
Q

E6 pathogenesis ?

A

E6 = binds with p53 = degrade it = upregulate the expression of telomerase = leads to cellular immortalization

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23
Q

E7 pathogenesis ?

A

E7 binds with hypophosphorylated active form of RB & promote the degradation via proteosome pathway —- inhibit p21 p27 = cyclin dependent kinase inhibitors

267

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24
Q

exo/ecto-cervix lining ?

A

squamous epithelium

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25
Q

endocervix lining ?

A

coloumnar

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26
Q

Squamouse metaplasia site ?

A

transformation zone / squamocolumnar juntion

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27
Q

what is transformation zone ?

A

267

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28
Q

how to identify undifferentiated cervical Ca ?

A

IHC

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29
Q

Cause of death in cervical carcinoma ?

A

renal failure

30
Q

clinical importance of transformation zone ?

A

zone is susceptible to oncogenic HPV

31
Q

Age of cervical carcinoma ?

32
Q

gross of cervical carcinoma ?

A

fungating / exophytic
infiltrative
ulcerating

33
Q

spread of cervical Ca ?

A

direct spread
distant / blood borne metastasis

34
Q

direct spread site of cervical Ca ?

A

paracervical soft tissue
urinary bladder
ureters
rectum
vagina

35
Q

distant metastasis site of cervical ca ?

A

liver
lung
bone
bone marrow

36
Q

local extension complications of cervical carcinoma ?

A

hydronephrosis
uremia
ureteral obstruction

37
Q

Diagnosis of cervical carcinoma ?

38
Q

History of cervical carcinoma ?

A

-vaginal bleeding
-faul smelling vaginal discharge
-painful coitus - dyspareunia
-pelvic pain
-wright loss

39
Q

clinical examination of cervical Ca ?

A

-cervix- fixed
-hard in consistency
-bleeds on touch
-irregular
-friable

269

40
Q

suppose tumi remote area te acho —– kivabe sekhane Dx korba ?

A

VIA
visual inspection + 5% acetic acid

41
Q

screenign test of cancer ?

42
Q

biopsy type ?

A

colposcopic & core biopsy

43
Q

vaccine dose schedule ?

A

0-2-6 months

44
Q

HPV vaccine group / age ?

A

school - 12-18
women - 16-25

45
Q

Which stain against vacccine

A

6 11 16 1 8

46
Q

screening and early detection of cervical carcinoma ?

A

VIA + acetic acid
pap smear
HPV DNA tsting by PCR
colposcopy

47
Q

kivabe bhujbo ideal pap smear sample paichi ?

A

-Transformation zone theke nibo
-good cellularity

48
Q

PAP full form ?

A

papnicolaou method

49
Q

when to collect first smear for pap ?

A

within 21 years /
within 3 years of onset of sexuala ctivity
thereeafter every 3 years

50
Q

women after 30 yeras old pap test ?

A

normal cytology + negative for HPV = screened every 5 years

51
Q

women with + HPV?

A

normal cytology + positive HPV = cervical cytology every 6-12 months

52
Q

which specimen for cervical carcinoma ?

A

wooden ayres spatula

53
Q

pap smear er jonno which end of spatula ?

A

humerus er mathar moto je end

54
Q

which type of cytolopathogy ?

54
Q

how to collect smear ?

A

anti-clockwise 360 degree

55
Q

cell types found in cervix >?

A

superficial
intermediate
parabasal
basal

56
Q

which cell is not found in pap smear >?

57
Q

fixative for pap smear ?

A

95% alchohol

58
Q

where the smear is fixed ?

A

koplins jar

59
Q

SCC % in cancer ?

60
Q

IHC —- intermediate filaments name ?

A

keratin
desmin
vimentin
glial filaments
neurofilaments

61
Q

vimentin site ?

A

mesenchymal tumoe

62
Q

desmin site ?

A

muscle tumor

63
Q

keeratin site >

A

carcinoma
mesothelioma

64
Q

role of HPV in cervical carcinoma ?

65
Q

endocervical columnar differentiattrion ———— ??

A

glandular intraepithelial lesion ———– invasive adenocarcinoma

66
Q

what is wooden ayres spatula made of ?

A

plastic / metalic

67
Q

HPV - E5—-microscopic view ?

A

koilonytic atypia

68
Q

mucous screting epithelium ??

A

endocervix – columnar

69
Q

biopsy type of cervix ?

Pathology-Medical-Prof (35 decks)

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