Grading of tumor Flashcards
Grading of tumor Definiton ??
Based on degree of differentiation of the tumor cells & in some Ca the no of mitosis & architectural features
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Grade-2 Grading of cancer ??
50-75% cell differentiation
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Grade-1 cancer ??
> 75% differentiated / normal cells
Grade-3 of Ca ??
25-50% cell differentiation
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Grade-4 of Ca ??
<25% cell differentiation
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Which one is important
Staging or Grading ???
Grading as it represents metastasis & spread
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Staging main system ??
TNM system
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Staging of tumor ?????
- Size of primary lesion
- Extent of spread to regional lymph node
- Presence/Absence of blood borne metastases
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Staging main points ??
- Clinical or investigational
- Clinically more important
- Tumor spread based
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Grading main points ???
- Histological
- Based on degree of differentiation
- No of mitosis
- Reflects aggresiveness
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TNM system full form ???
T=Extent of tumor
N= Regional lymph node involvement
M=Metastasis
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T= Extent Of Tumor no ???
T0 = Carcinoma in situ
T1 — T4 = Inc in primary tumor size
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N = Regional lymph node involement no ??
N0 = no nodal involvement
N1 — N3 = inc in involvement of an increasing no & range of nodes
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M=Metastasis no ???
M0 = No distant metastasis
M1 = Blood borne metastasis
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Importance of staging & grading ???
Selection of best modality of Tx for the patient
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