Normocytic-Normochromic-Aplastic & Haemolytic Anaemia Flashcards
1
Q
Aplastic anaemia Defination ??
A
It is defined as pancytopenia resulting from aplasia of the BM
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2
Q
Inherited cause of AA ??
A
- fanconi anamemia
- telomerase defect
3
Q
acquired cause of AA ??
A
- Idiopathic
- acquired defect in stem cell
- cytotoxic drugs
- benzene
- inorganic arsenals
- EBV
- CMV
- HIV4
- herpes zooster
- chloramphenicol + body irridation
4
Q
cardinal signs of AA ??
A
- No lymphadenopathy
- no hepatosplenomegaly
- no bony tenderness
5
Q
cause of death in AA ??
A
- Pneumonia
- septicaemia
- cerebral hemorrhage
6
Q
BM condition in AA ??
A
BM hypoplasia
7
Q
Pathogenesis of AA ??
A
- direct damage to HSC & Progenitor cells
- primary stem cells abnormality
- immune mediated destructiom
8
Q
Normocytic means ??
A
normal size of RBC
9
Q
Normochromic means ??
A
normal Hb content
10
Q
CBC of AA ?
A
- Hb% -
- PCV -
- RBC -
- WBC -
- P -
- ESR +
- Reticulocyte count -
AA + MM + Myelofibrosis same CBC
11
Q
PBF of AA ?/
A
- RBC = N-N-A-P
- WBC Neutropenia + lymphocytosis
- P = -
12
Q
Confirmatory test for AA >??
A
BM
13
Q
BM of AA ?/
A
- C=Hypocellular / hypoplasia
- M/E = N
- E=-
- G-
- M-
14
Q
Why ESR is high in AA ??
A
- HSC
- inability to produce normal no of mature cells
- RBC count very low
- ESR high
15
Q
Criteria for severe AA ?/
A
- granulocytes =<0.5109l
- p = same
- reticulocytes = >1%
- marrow cellularity = <25%
