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Pathology-Medical-Prof > Normocytic-Normochromic-Aplastic & Haemolytic Anaemia > Flashcards

Normocytic-Normochromic-Aplastic & Haemolytic Anaemia Flashcards

1
Q

Aplastic anaemia Defination ??

A

It is defined as pancytopenia resulting from aplasia of the BM

373

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2
Q

Inherited cause of AA ??

A
  • fanconi anamemia
  • telomerase defect
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3
Q

acquired cause of AA ??

A
  1. Idiopathic
  2. acquired defect in stem cell
  3. cytotoxic drugs
  4. benzene
  5. inorganic arsenals
  6. EBV
  7. CMV
  8. HIV4
  9. herpes zooster
  10. chloramphenicol + body irridation
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4
Q

cardinal signs of AA ??

A
  1. No lymphadenopathy
  2. no hepatosplenomegaly
  3. no bony tenderness
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5
Q

cause of death in AA ??

A
  1. Pneumonia
  2. septicaemia
  3. cerebral hemorrhage
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6
Q

BM condition in AA ??

A

BM hypoplasia

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7
Q

Pathogenesis of AA ??

A
  • direct damage to HSC & Progenitor cells
  • primary stem cells abnormality
  • immune mediated destructiom
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8
Q

Normocytic means ??

A

normal size of RBC

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9
Q

Normochromic means ??

A

normal Hb content

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10
Q

CBC of AA ?

A
  1. Hb% -
  2. PCV -
  3. RBC -
  4. WBC -
  5. P -
  6. ESR +
  7. Reticulocyte count -

AA + MM + Myelofibrosis same CBC

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11
Q

PBF of AA ?/

A
  1. RBC = N-N-A-P
  2. WBC Neutropenia + lymphocytosis
  3. P = -
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12
Q

Confirmatory test for AA >??

A

BM

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13
Q

BM of AA ?/

A
  • C=Hypocellular / hypoplasia
  • M/E = N
  • E=-
  • G-
  • M-
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14
Q

Why ESR is high in AA ??

A
    • HSC
  • inability to produce normal no of mature cells
  • RBC count very low
  • ESR high
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15
Q

Criteria for severe AA ?/

A
  1. granulocytes =<0.5109l
  2. p = same
  3. reticulocytes = >1%
  4. marrow cellularity = <25%
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16
Q

define pancytopenia ??

A
  1. anaemia
  2. neutropenia
  3. thrombocytopenia
17
Q

BM failure cause of Pancytopenia ??

A
  1. AA
  2. Viral D
  3. DRUGS
18
Q

BM infiltration cause of AA ?/

A
  1. AL
  2. Myeloma
  3. lymphoma
  4. carcinoma
  5. myelodysplastic s
  6. myelofibrosis
19
Q

Infective hematopoiesis cause of p ?/

A
  1. AIDS
  2. megaloblastic anaemia
20
Q

Peripheral destruction/pooling cause of Pancytopenia ??

A
  • SLE
  • malaria
  • hypersplenism
21
Q

which antibiotics cause Pancytopenia /

A

chloramphenicol

21
Q

what is Haemolytic a /

A

excess RBC destrcution
shortened life span of RBC

22
Q

acquired cause of HA ??

A

paroxysmal nocturnal haemoglobinuria

23
Q

congenital cause of HA ?/

A
  • MEMbrane defects
  • hereditory spherocytosis
  • hereditory elliptocytosis
  • hb defect
  • sickle cell a
  • th
  • T
  • Enzyme defect
  • G-6PD deficeincy
  • pyruvate kinase deficiency

Pathology-Medical-Prof (35 decks)

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