Microcytic Hyporchromic-T-IDA-Sideroblastic A Flashcards

1
Q

Microcytic hypochromic anaemia types /

A
  1. IDA
  2. T
  3. Anemia of chronic cause
  4. sideroblastic anameia
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2
Q

CBC of IDA

A
  1. Hb% -
  2. PCV -
  3. RBC -
  4. WBC - N
  5. P - +
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3
Q

Anisocytosis ??

A

variation in size of RBC

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3
Q

PBF of IDA ??

A
  1. RBC- micropcytic hypochromic - A-P-Target cells - Pencil shaped cells
  2. WBC - N
  3. P - +
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4
Q

Poikilocytosis ??

A

variation in shape of RBC

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5
Q

Confirmatory test of IDA ?/

A

BIOCHEMICAL findings
serum iron profile

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5
Q

BM of IDA ?/

A
  1. C= erythroid hyperplasia
  2. M/E = -
  3. E= hyperactive
  4. G=N
  5. M=N
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6
Q

Special tests for IDA ??

A
  • Stool for R/E - ova of hookworm
  • x-ray KUB region
  • USG of lower abdomen
  • Proctoscopy
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6
Q

serum Fe profile ??

A
  1. serum fe = 50-175 micro mol/L
  2. serum ferritin = 15-300 micro gram /L
  3. TIBC = 40-80 micro mol /L
  4. PSOIBC = 33%
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6
Q

Serum Fe profile of IDA ??

A
  • Serum Fe -
  • serum ferritin -
  • TIBC +
  • PSOIBC -
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7
Q

Confirmatory test for T ??

A
  1. Hb electrophoresis
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8
Q

CBC of T ??

A
  1. Hb% = severely dec
  2. PCV -
  3. RBC -
  4. WBC N
  5. P N
  6. Reticulocyte count +
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9
Q

PBF of T ??

A
  1. RBC-microcytic hypochromic A -P-target cells-pencils cells - basophilic stippling
    spherocytes
    schistocytes
  2. WBC & P- Normal ``
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10
Q

BM of T ?

A

same as IDA

`

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11
Q

X-ray findings of T ??

A
  • Increased diploic space
  • hair on end appearance
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12
Q

serum Fe profile of T ??

A

ALL N

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13
Q

What is T ?
348

A

Heterogenous group of inherited disorders which result from a genetic abnormality of globin chain

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14
Q

haemoglobinopathies ?????

A

production of structurally defective Hb due to abnormalities in the formation of the globin moiety of the molecule

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15
Q

T vs Haemoglobinopathies ?
1 line

A

T= Quantitative
H = Qualitative

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16
Q

Hb electrophoresis of T ??

A
  1. Complete absence of Hb-A
  2. Almost all circulatory Hb-F
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17
Q

alpha - T type ??

A
  • silent carrier
  • AT trait
  • Hb-h DISEASE
  • hb-barts hydrops fetalis
18
Q

anemia = defination ?

A

decrease below normal limit ( below the reference level for age & sex of individual) of Hb conc , erthryocyte count/hematocrit 335

19
Q

Red cell indices ?

A

MCV = 76-96 fl
MCH = 27-32 pgm
MCHC = 31-35 gm/dl

20
Q

central pllor of hypochromic ?

21
Q

central pallor of polychromic ?

21
Q

PBF e IDA vs T ?

A

PBF IDA = beshi Pencil shaped cells
T = beshi target shpaed cells

21
Q

cnetral pallor of normochromic ?

22
Q

RCI in microcytic hypochromic ?

A

all decrease

22
Q

what type of disease is T ?

A

autosomal recessive disorder

23
Q

CBC result of T vs IDA ?

A

IDA = hb dec
T = Hb severely dec

23
Q

iron is seen by which stain ?

A

Prussian blue

24
Q

what is microcytosis ?

A

MCV ———-

24
Q

which Anemia confirmatory test is bone marrow ?

A

megaloblastic anemia
aplastic anemia
sideroblastic anemia

25
Q

What is hypochromia ?

A

MCH ————–

26
Q

Tx of IDA ?

A

correction of the disorder
oral iron administration - ferous sulphate / gluconate / fumarate

26
Q

most important serum iron profile which one ?

A

serum ferritin
15-300 microGm/L

27
Q

S/S of T appear when ?

A

at the age of 6 months

27
Q

Hb electrophoresis result of T ?

A

——- Total absent = Hb A
All normal = Hb-A2
All the circulating Hb being = Hb-F

28
Q

examples of Haemoglobinopathies ?

A

sickle H
Hb-C h
Hb-E h
Hb-D h
the unstable Hb h
H associated with polycythaemia
sickle cell trait
sickle cell beta T

29
Q

Tx of T ?

A

blood transfusion
general Mx
splenectomy
bone marrow transplantation
folic acid supplementation
zinc supplementation

30
Q

Parental Dx of T ??

A

chorionic villus
amniocentesis

31
Q

H vs T = ??

32
Q

RCI of H ?

A

normochromic normocytic

33
Q

Hb electrophoresis of H ?

A

HbS - 75-95%
HbA2
HbF

34
Q

Target cells in PBF example ?

HITS
358

A

Haemoglobinopathies
IDA
T
Poat-splenectomy
Liver D

35
Q

confirmatory test of sideroblastic anemia ?

A

Bone marrow

36
Q

Bone marrow of sideroblastic anemia >

A

ringed sideroblast

37
Q

what is target cells ?

A

abnormal RBC
central round stained area
peripheral rim of haemoglobinized cytoplasm

38
Q

cause of anemia in BEta T ?

A

intra-medullary red cell destruction
reduced life span of RBC
sequestration in spleen
folate deficiency

39
Q

cause of hepatosplenomegaly in beta T ?

A

extra-medullary hemopoiesis
haemochromatosis