Microcytic Hyporchromic-T-IDA-Sideroblastic A Flashcards
Microcytic hypochromic anaemia types /
- IDA
- T
- Anemia of chronic cause
- sideroblastic anameia
CBC of IDA
- Hb% -
- PCV -
- RBC -
- WBC - N
- P - +
Anisocytosis ??
variation in size of RBC
PBF of IDA ??
- RBC- micropcytic hypochromic - A-P-Target cells - Pencil shaped cells
- WBC - N
- P - +
Poikilocytosis ??
variation in shape of RBC
Confirmatory test of IDA ?/
BIOCHEMICAL findings
serum iron profile
BM of IDA ?/
- C= erythroid hyperplasia
- M/E = -
- E= hyperactive
- G=N
- M=N
Special tests for IDA ??
- Stool for R/E - ova of hookworm
- x-ray KUB region
- USG of lower abdomen
- Proctoscopy
serum Fe profile ??
- serum fe = 50-175 micro mol/L
- serum ferritin = 15-300 micro gram /L
- TIBC = 40-80 micro mol /L
- PSOIBC = 33%
Serum Fe profile of IDA ??
- Serum Fe -
- serum ferritin -
- TIBC +
- PSOIBC -
Confirmatory test for T ??
- Hb electrophoresis
CBC of T ??
- Hb% = severely dec
- PCV -
- RBC -
- WBC N
- P N
- Reticulocyte count +
PBF of T ??
- RBC-microcytic hypochromic A -P-target cells-pencils cells - basophilic stippling
spherocytes
schistocytes - WBC & P- Normal ``
BM of T ?
same as IDA
`
X-ray findings of T ??
- Increased diploic space
- hair on end appearance
serum Fe profile of T ??
ALL N
What is T ?
348
Heterogenous group of inherited disorders which result from a genetic abnormality of globin chain
haemoglobinopathies ?????
production of structurally defective Hb due to abnormalities in the formation of the globin moiety of the molecule
T vs Haemoglobinopathies ?
1 line
T= Quantitative
H = Qualitative
Hb electrophoresis of T ??
- Complete absence of Hb-A
- Almost all circulatory Hb-F
alpha - T type ??
- silent carrier
- AT trait
- Hb-h DISEASE
- hb-barts hydrops fetalis
anemia = defination ?
decrease below normal limit ( below the reference level for age & sex of individual) of Hb conc , erthryocyte count/hematocrit 335
Red cell indices ?
MCV = 76-96 fl
MCH = 27-32 pgm
MCHC = 31-35 gm/dl
central pllor of hypochromic ?
> 1/3
central pallor of polychromic ?
no pallor
PBF e IDA vs T ?
PBF IDA = beshi Pencil shaped cells
T = beshi target shpaed cells
cnetral pallor of normochromic ?
< 1/3
RCI in microcytic hypochromic ?
all decrease
what type of disease is T ?
autosomal recessive disorder
CBC result of T vs IDA ?
IDA = hb dec
T = Hb severely dec
iron is seen by which stain ?
Prussian blue
what is microcytosis ?
MCV ———-
which Anemia confirmatory test is bone marrow ?
megaloblastic anemia
aplastic anemia
sideroblastic anemia
What is hypochromia ?
MCH ————–
Tx of IDA ?
correction of the disorder
oral iron administration - ferous sulphate / gluconate / fumarate
most important serum iron profile which one ?
serum ferritin
15-300 microGm/L
S/S of T appear when ?
at the age of 6 months
Hb electrophoresis result of T ?
——- Total absent = Hb A
All normal = Hb-A2
All the circulating Hb being = Hb-F
examples of Haemoglobinopathies ?
sickle H
Hb-C h
Hb-E h
Hb-D h
the unstable Hb h
H associated with polycythaemia
sickle cell trait
sickle cell beta T
Tx of T ?
blood transfusion
general Mx
splenectomy
bone marrow transplantation
folic acid supplementation
zinc supplementation
Parental Dx of T ??
chorionic villus
amniocentesis
H vs T = ??
352 page
RCI of H ?
normochromic normocytic
Hb electrophoresis of H ?
HbS - 75-95%
HbA2
HbF
Target cells in PBF example ?
HITS
358
Haemoglobinopathies
IDA
T
Poat-splenectomy
Liver D
confirmatory test of sideroblastic anemia ?
Bone marrow
Bone marrow of sideroblastic anemia >
ringed sideroblast
what is target cells ?
abnormal RBC
central round stained area
peripheral rim of haemoglobinized cytoplasm
cause of anemia in BEta T ?
intra-medullary red cell destruction
reduced life span of RBC
sequestration in spleen
folate deficiency
cause of hepatosplenomegaly in beta T ?
extra-medullary hemopoiesis
haemochromatosis