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Microcytic Hyporchromic-T-IDA-Sideroblastic A Flashcards

1
Q

Microcytic hypochromic anaemia types /

A
  1. IDA
  2. T
  3. Anemia of chronic cause
  4. sideroblastic anameia
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2
Q

CBC of IDA

A
  1. Hb% -
  2. PCV -
  3. RBC -
  4. WBC - N
  5. P - +
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3
Q

Anisocytosis ??

A

variation in size of RBC

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3
Q

PBF of IDA ??

A
  1. RBC- micropcytic hypochromic - A-P-Target cells - Pencil shaped cells
  2. WBC - N
  3. P - +
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4
Q

Poikilocytosis ??

A

variation in shape of RBC

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5
Q

Confirmatory test of IDA ?/

A

BIOCHEMICAL findings
serum iron profile

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5
Q

BM of IDA ?/

A
  1. C= erythroid hyperplasia
  2. M/E = -
  3. E= hyperactive
  4. G=N
  5. M=N
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6
Q

Special tests for IDA ??

A
  • Stool for R/E - ova of hookworm
  • x-ray KUB region
  • USG of lower abdomen
  • Proctoscopy
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6
Q

serum Fe profile ??

A
  1. serum fe = 50-175 micro mol/L
  2. serum ferritin = 15-300 micro gram /L
  3. TIBC = 40-80 micro mol /L
  4. PSOIBC = 33%
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6
Q

Serum Fe profile of IDA ??

A
  • Serum Fe -
  • serum ferritin -
  • TIBC +
  • PSOIBC -
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7
Q

Confirmatory test for T ??

A
  1. Hb electrophoresis
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8
Q

CBC of T ??

A
  1. Hb% = severely dec
  2. PCV -
  3. RBC -
  4. WBC N
  5. P N
  6. Reticulocyte count +
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9
Q

PBF of T ??

A
  1. RBC-microcytic hypochromic A -P-target cells-pencils cells - basophilic stippling
    spherocytes
    schistocytes
  2. WBC & P- Normal ``
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10
Q

BM of T ?

A

same as IDA

`

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11
Q

X-ray findings of T ??

A
  • Increased diploic space
  • hair on end appearance
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12
Q

serum Fe profile of T ??

A

ALL N

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13
Q

What is T ?
348

A

Heterogenous group of inherited disorders which result from a genetic abnormality of globin chain

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14
Q

haemoglobinopathies ?????

A

production of structurally defective Hb due to abnormalities in the formation of the globin moiety of the molecule

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15
Q

T vs Haemoglobinopathies ?
1 line

A

T= Quantitative
H = Qualitative

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16
Q

Hb electrophoresis of T ??

A
  1. Complete absence of Hb-A
  2. Almost all circulatory Hb-F
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17
Q

alpha - T type ??

A
  • silent carrier
  • AT trait
  • Hb-h DISEASE
  • hb-barts hydrops fetalis
18
Q

anemia = defination ?

A

decrease below normal limit ( below the reference level for age & sex of individual) of Hb conc , erthryocyte count/hematocrit 335

19
Q

Red cell indices ?

A

MCV = 76-96 fl
MCH = 27-32 pgm
MCHC = 31-35 gm/dl

20
Q

central pllor of hypochromic ?

21
central pallor of polychromic ?
no pallor
21
PBF e IDA vs T ?
PBF IDA = beshi Pencil shaped cells T = beshi target shpaed cells
21
cnetral pallor of normochromic ?
< 1/3
22
RCI in microcytic hypochromic ?
all decrease
22
what type of disease is T ?
autosomal recessive disorder
23
CBC result of T vs IDA ?
IDA = hb dec T = Hb severely dec
23
iron is seen by which stain ?
Prussian blue
24
what is microcytosis ?
MCV ----------
24
which Anemia confirmatory test is bone marrow ?
megaloblastic anemia aplastic anemia sideroblastic anemia
25
What is hypochromia ?
MCH --------------
26
Tx of IDA ?
correction of the disorder oral iron administration - ferous sulphate / gluconate / fumarate
26
most important serum iron profile which one ?
serum ferritin 15-300 microGm/L
27
S/S of T appear when ?
at the age of 6 months
27
Hb electrophoresis result of T ?
------- Total absent = Hb A All normal = Hb-A2 All the circulating Hb being = Hb-F
28
examples of Haemoglobinopathies ?
sickle H Hb-C h Hb-E h Hb-D h the unstable Hb h H associated with polycythaemia sickle cell trait sickle cell beta T
29
Tx of T ?
blood transfusion general Mx splenectomy bone marrow transplantation folic acid supplementation zinc supplementation
30
Parental Dx of T ??
chorionic villus amniocentesis
31
H vs T = ??
352 page
32
RCI of H ?
normochromic normocytic
33
Hb electrophoresis of H ?
HbS - 75-95% HbA2 HbF
34
Target cells in PBF example ? HITS 358
Haemoglobinopathies IDA T Poat-splenectomy Liver D
35
confirmatory test of sideroblastic anemia ?
Bone marrow
36
Bone marrow of sideroblastic anemia >
ringed sideroblast
37
what is target cells ?
abnormal RBC central round stained area peripheral rim of haemoglobinized cytoplasm
38
cause of anemia in BEta T ?
intra-medullary red cell destruction reduced life span of RBC sequestration in spleen folate deficiency
39
cause of hepatosplenomegaly in beta T ?
extra-medullary hemopoiesis haemochromatosis

Pathology-Medical-Prof (36 decks)

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