Paraproteinaemia & Multiple Myeloma Flashcards
what is Paraproteineaemia ??
- abnormal proliferation of
- Immunoglobulins producings cells
- inc in serum level of a single homogenous Ig /its fragments
diseases of Paraproteinemia ?
- multiple myeloma
- non -hodgkins lymphoma
- primary amyloidosis
- CLL
- heavy chain disease
What is Multiple myeloma ??
it is neoplastic proliferation of plasma cells commonly associate dwith malignant plasma cells accumulate in the bone marrow and other body tissues
CBC of MM ??
Same as Myelofibrosis ??
- Hb% -
- PCV -
- RBC -
- WBC -
- P -
- ESR +
PBF of MM ?
- RBC - -A-P-Rouleux formation
- WBC -
- P -
Same as myelofibrosis
BM of MM ??
- C=Acellular
- M/E =N
- E=-
4.G=Marrow plasmocytosis
5.M=-
Other test for MM ?
- X-ray =multiple punced out lesion
- urinary M protein/bence zones protein
which biopsy in MM ??
Trephine
confirmational test for MM ??
MONOCLONAL m protein
what is BZP ??
It is an immunoglobulin light chain either Kappa/lambda
BZ proteinuria what ??
when urine contain BZP
how to detect BZP ?
- Heat test
- electrophpretic method
in which conditions BZP is seen ???
- MM
- L
- lymphoma
- amyloidosis
- macroglobulimaemia
cardinal signs Of MM ?
BRAC
426
- bony lesion - multiple punced out lesion
- BZP
- RF
- anaemia
- hy[percalcaemia
causes of HyperViscosity syndrome ?
- PRV
- MM
- A/C L
- haemophilia
why ESR is inc in MM ?
MM = inc paraprotein
= inc rouleaux
= inc ESR
Plasma cell in BM found in which disease ?
MM
Aplastic anemia
liver cirrhosis
secondary carcinoma
SLE
PAN
RA
TB
Malaria
plasma cell count in MM ?
> 30%
How to differentiate RBC & WBC in urine ?
WBC have - granules — RBC donot
WBC - larger than RBC
if 5% acetic acid + RBC = destroy
but 5% acetic acid + WBC = lobe of WBC more clear
RBC vs Yeast ?
5% acetic acid + RBC = destroy
+ yeast = remain same
cause of neutrophilia ?
acute appendicitis
acute tonsilitis
pyelonephritis
bacterial pneumonia
cause of eosinophilia <
helminthic infection
loefflers syndrome
allergic disorder
pulmonary eosinophilia
cause of lymphocytosis <
viral infection
infectious mononucleosis
mumps
rubella
TB
pertussis
immunoproliferative disease name >
lymphoproliferative d
hypergammaglobulinemia
paraproteinemia
mature plasma cell character?
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basophilic cytoplasm
cartwheel cytoplasm
perinuclear hallo
eccentric nucleus
immature plasma cell characters?
russell bodies
perinuclear hallo
vacuolation
vascular nucleus with prominent nuclei
mature VS immature plasma cell <
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