Paraproteinaemia & Multiple Myeloma

Question 1

what is Paraproteineaemia ??

Answer 1

• abnormal proliferation of
• Immunoglobulins producings cells
• inc in serum level of a single homogenous Ig /its fragments

Question 2

diseases of Paraproteinemia ?

Answer 2

1. multiple myeloma
2. non -hodgkins lymphoma
3. primary amyloidosis
4. CLL
5. heavy chain disease

Question 3

What is Multiple myeloma ??

Answer 3

it is neoplastic proliferation of plasma cells commonly associate dwith malignant plasma cells accumulate in the bone marrow and other body tissues

Question 4

CBC of MM ??

Same as Myelofibrosis ??

Answer 4

1. Hb% -
2. PCV -
3. RBC -
4. WBC -
5. P -
6. ESR +

Question 5

PBF of MM ?

Answer 5

1. RBC - -A-P-Rouleux formation
2. WBC -
3. P -

Same as myelofibrosis

Question 6

BM of MM ??

Answer 6

1. C=Acellular
2. M/E =N
3. E=-
   4.G=Marrow plasmocytosis
   5.M=-

Question 7

Other test for MM ?

Answer 7

1. X-ray =multiple punced out lesion
2. urinary M protein/bence zones protein

Question 8

which biopsy in MM ??

Answer 8

Trephine

Question 9

confirmational test for MM ??

Answer 9

MONOCLONAL m protein

Question 10

what is BZP ??

Answer 10

It is an immunoglobulin light chain either Kappa/lambda

Question 11

BZ proteinuria what ??

Answer 11

when urine contain BZP

Question 12

how to detect BZP ?

Answer 12

1. Heat test
2. electrophpretic method

Question 13

in which conditions BZP is seen ???

Answer 13

• MM
• L
• lymphoma
• amyloidosis
• macroglobulimaemia

Question 14

cardinal signs Of MM ?
BRAC

426

Answer 14

1. bony lesion - multiple punced out lesion
2. BZP
3. RF
4. anaemia
5. hy[percalcaemia

Question 15

causes of HyperViscosity syndrome ?

Answer 15

• PRV
• MM
• A/C L
• haemophilia

Question 16

why ESR is inc in MM ?

Answer 16

MM = inc paraprotein
= inc rouleaux
= inc ESR

Question 16

Plasma cell in BM found in which disease ?

Answer 16

MM
Aplastic anemia
liver cirrhosis
secondary carcinoma
SLE
PAN
RA
TB
Malaria

Question 16

plasma cell count in MM ?

Answer 16

> 30%

Question 17

How to differentiate RBC & WBC in urine ?

Answer 17

WBC have - granules — RBC donot
WBC - larger than RBC
if 5% acetic acid + RBC = destroy
but 5% acetic acid + WBC = lobe of WBC more clear

Question 18

RBC vs Yeast ?

Answer 18

5% acetic acid + RBC = destroy
+ yeast = remain same

Question 19

cause of neutrophilia ?

Answer 19

acute appendicitis
acute tonsilitis
pyelonephritis
bacterial pneumonia

Question 20

cause of eosinophilia <

Answer 20

helminthic infection
loefflers syndrome
allergic disorder
pulmonary eosinophilia

Question 21

cause of lymphocytosis <

Answer 21

viral infection
infectious mononucleosis
mumps
rubella
TB
pertussis

Question 22

immunoproliferative disease name >

Answer 22

lymphoproliferative d
hypergammaglobulinemia
paraproteinemia

Question 23

mature plasma cell character? 423

Answer 23

basophilic cytoplasm cartwheel cytoplasm perinuclear hallo eccentric nucleus

Question 24

immature plasma cell characters?

Answer 24

russell bodies perinuclear hallo vacuolation vascular nucleus with prominent nuclei

Question 25

mature VS immature plasma cell <

Answer 25

423