Paraproteinaemia & Multiple Myeloma

Question 1

what is Paraproteineaemia ??

Answer 1

• abnormal proliferation of
• Immunoglobulins producings cells
• inc in serum level of a single homogenous Ig /its fragments

Question 2

diseases of Paraproteinemia ?

Answer 2

1. multiple myeloma
2. non -hodgkins lymphoma
3. primary amyloidosis
4. CLL
5. heavy chain disease

Question 3

What is Multiple myeloma ??

Answer 3

it is neoplastic proliferation of plasma cells commonly associate dwith malignant plasma cells accumulate in the bone marrow and other body tissues

Question 4

CBC of MM ??

Same as Myelofibrosis ??

Answer 4

1. Hb% -
2. PCV -
3. RBC -
4. WBC -
5. P -
6. ESR +

Question 5

PBF of MM ?

Answer 5

1. RBC - -A-P-Rouleux formation
2. WBC -
3. P -

Same as myelofibrosis

Question 6

BM of MM ??

Answer 6

1. C=Acellular
2. M/E =N
3. E=-
   4.G=Marrow plasmocytosis
   5.M=-

Question 7

Other test for MM ?

Answer 7

1. X-ray =multiple punced out lesion
2. urinary M protein/bence zones protein

Question 8

which biopsy in MM ??

Answer 8

Trephine

Question 9

confirmational test for MM ??

Answer 9

MONOCLONAL m protein

Question 10

what is BZP ??

Answer 10

It is an immunoglobulin light chain either Kappa/lambda

Question 11

BZ proteinuria what ??

Answer 11

when urine contain BZP

Question 12

how to detect BZP ?

Answer 12

1. Heat test
2. electrophpretic method

Question 13

in which conditions BZP is seen ???

Answer 13

• MM
• L
• lymphoma
• amyloidosis
• macroglobulimaemia

Question 14

cardinal signs Of MM ?

Answer 14

1. bony lesion - multiple punced out lesion
2. BZP
3. RF
4. anaemia
5. hy[percalcaemia

Question 15

causes of Hyperciscosity syndrome ?

Answer 15

• PRV
• MM
• A/C L
• haemophilia