Bleeding Disorders Flashcards
what is hemorrhagic disorder ?
it is a group of disorders of widely difeering etiology which have in common an abnormal tendency to bleed due to a defect in the mechanism of heamostasis
BD due to vascular defect ?
hereditary haemorrhagic telangiectasis
ehlers danlos disease
purpura simplex
senile purpura
polyarteritis nodosa
bleeding disorder of platelet abnormalities >
thrombocytopenia
thrombathenia
thrombpcytosis
thrombocythaemia
BD of coagulation defect ?
H A & B
Von willebrand disease
screening test for BD ?
BT
CT
PT
APTT
TT
PC
Normal BT ?
<6min
Normal CT ?
6-12 MIN
PT ???
9-12 sec
APTT ??
32-40 sec
TT ??
10-14 sec
PC ?
1.5-4 laks/mm3
BT prolonged in which D ?
ITP
CT + APTT prolonged= ??
Haemophilia A + B
BT CT APTT TT all prolonged = ??
DIC
Confirmatory test of ITP?
Bone marrow
—- inc megakaryopoiesis
Anti-platelet AB
CBC of ITP ?
all = Normal
Platelet count = dec
screening test result of ITP ?
BT = prolonged
CT APTT PC TT = dec
cause of prolong TT ?
DIC
APTT what ??
time required for clotting to take place in intrinsic pathway
Other name of DIC ?
consumption coagulopathy
defibrination syndrome 448
PT what ?
time required for clot in extrinsic pathway
causes of thrombocytopenia?
437
VWF disease which one prolonged ?
BT CT APTT
VWd confirmatory test ?
factor VIII ASSAY = normal/dec
VWF assat = dec/nai
PC normal
but BT prolonged why ?
platelet adhesion defect resulting from VWF deficiency
WHich parhway defect in H >
intricnsic
why factor-VIII is dec in VWF ?
VWF prevents the lysis of factor-VIII
WHY APTT is prolonged in Haemophilia >
APTT is prolobged due to inc in 1 2 5 8 9 10 factor
factor 8 specific for APTT
cardinal sign of haemophilia >
haemoarthrosis
Hx presentation of Haempohilia <
circumcision
tooth extraction
carrier of hemophilia?
female
when female are affected in hemophilia?
affected father + carrier mother
turners syndrome
lionization of normal X chromosome
common site of muscle hematoma in hemophilia <
psoas
calf muscle
confirmatory Dx of haemophilia <
H-A= factor VIII assya = dec
H-B= factor IX assay = dech
which type of anemia in DIC >
microangiopathic hemolytic anemia
confirmatory test of DIC >
FDP
fibrin degradation protein
in which case BT & CT both prolonged >
VWD
DIC
immune mechanism cause of thrombocytopenia <
ITP
post traumatic purpura
drug - vancomycin + quinine
=== Platelet survival; dec
dec consumption of P in thrombocytopenia?
DIC
microangiopathic hemolytic anemia
viral - dengue
HIV
Dec P production in thrombocytopenia ???
leukaemia
lymphoma
aplastic anemia
fanconi anemia
liver disease
myeloma
myelofibrosis
437
