Bleeding Disorders

Question 1

what is hemorrhagic disorder ?

Answer 1

it is a group of disorders of widely difeering etiology which have in common an abnormal tendency to bleed due to a defect in the mechanism of heamostasis

Question 2

BD due to vascular defect ?

Answer 2

hereditary haemorrhagic telangiectasis
ehlers danlos disease
purpura simplex
senile purpura
polyarteritis nodosa

Question 3

bleeding disorder of platelet abnormalities >

Answer 3

thrombocytopenia
thrombathenia
thrombpcytosis
thrombocythaemia

Question 4

BD of coagulation defect ?

Answer 4

H A & B
Von willebrand disease

Question 5

screening test for BD ?

Answer 5

BT
CT
PT
APTT
TT
PC

Question 6

Normal BT ?

Answer 6

<6min

Question 7

Normal CT ?

Answer 7

6-12 MIN

Question 8

PT ???

Answer 8

9-12 sec

Question 9

APTT ??

Answer 9

32-40 sec

Question 10

TT ??

Answer 10

10-14 sec

Question 11

PC ?

Answer 11

1.5-4 laks/mm3

Question 12

BT prolonged in which D ?

Answer 12

ITP

Question 13

CT + APTT prolonged= ??

Answer 13

Haemophilia A + B

Question 14

BT CT APTT TT all prolonged = ??

Answer 14

DIC

Question 15

Confirmatory test of ITP?

Answer 15

Bone marrow
—- inc megakaryopoiesis
Anti-platelet AB

Question 16

CBC of ITP ?

Answer 16

all = Normal
Platelet count = dec

Question 17

screening test result of ITP ?

Answer 17

BT = prolonged
CT APTT PC TT = dec

Question 18

cause of prolong TT ?

Answer 18

DIC

Question 19

APTT what ??

Answer 19

time required for clotting to take place in intrinsic pathway

Question 20

Other name of DIC ?

Answer 20

consumption coagulopathy
defibrination syndrome 448

Question 21

PT what ?

Answer 21

time required for clot in extrinsic pathway

Question 22

causes of thrombocytopenia?

Answer 22

437

Question 23

VWF disease which one prolonged ?

Answer 23

BT CT APTT

Question 24

VWd confirmatory test ?

Answer 24

factor VIII ASSAY = normal/dec
VWF assat = dec/nai

Question 25

PC normal but BT prolonged why ?

Answer 25

platelet adhesion defect resulting from VWF deficiency

Question 26

WHich parhway defect in H >

Answer 26

intricnsic

Question 26

why factor-VIII is dec in VWF ?

Answer 26

VWF prevents the lysis of factor-VIII

Question 27

WHY APTT is prolonged in Haemophilia >

Answer 27

APTT is prolobged due to inc in 1 2 5 8 9 10 factor factor 8 specific for APTT

Question 28

cardinal sign of haemophilia >

Answer 28

haemoarthrosis

Question 29

Hx presentation of Haempohilia <

Answer 29

circumcision tooth extraction

Question 29

carrier of hemophilia?

Answer 29

female

Question 30

when female are affected in hemophilia?

Answer 30

affected father + carrier mother turners syndrome lionization of normal X chromosome

Question 31

common site of muscle hematoma in hemophilia <

Answer 31

psoas calf muscle

Question 32

confirmatory Dx of haemophilia <

Answer 32

H-A= factor VIII assya = dec H-B= factor IX assay = dech

Question 33

which type of anemia in DIC >

Answer 33

microangiopathic hemolytic anemia

Question 34

confirmatory test of DIC >

Answer 34

FDP fibrin degradation protein

Question 35

in which case BT & CT both prolonged >

Answer 35

VWD DIC

Question 36

immune mechanism cause of thrombocytopenia <

Answer 36

ITP post traumatic purpura drug - vancomycin + quinine === Platelet survival; dec

Question 37

dec consumption of P in thrombocytopenia?

Answer 37

DIC microangiopathic hemolytic anemia viral - dengue HIV

Question 38

Dec P production in thrombocytopenia ???

Answer 38

leukaemia lymphoma aplastic anemia fanconi anemia liver disease myeloma myelofibrosis 437