Myeloproliferative Disorder

Question 1

Myeloproliferative syndrome defination ??

Answer 1

• proliferative neoplastic disorder
• uncontrolled proliferation of abnormal progenitor cells
• which are capable of producing myeloid,erythroid,megakaryocytic series

Question 2

names of myeloproliferative disease ?

Answer 2

1. polycythemia rubra vera
2. CML
3. myelofibrosis
4. essential thrombocythemia

Question 3

what is myelofibrosis ??

Answer 3

fibrosis & collagen formation in the marrow

Question 4

CBC of myelofibrosis ?

Answer 4

1. Hb% -
2. PCV -
3. RBC -
4. WBC-
5. P -
6. ESR +

Question 5

PBF of Myelofibrosis ?

Answer 5

1. RBC = N-N-A-P-tear drop cells - rouleux formation
2. WBC -
3. P -

Question 6

BM of myelofibrosis ?

Answer 6

1. C Acellular
2. M/E Normal
3. E -
4. G-
5. M-

Question 7

other test for myelofibrosis ?

Answer 7

• folic acid -
• uric acid +
• leukocyte alkaline phosphatse score +

Question 8

Polycythemia-Def ?

Answer 8

elevated levels of all blood components

Question 9

when it is True Polycythemia ?

Answer 9

Elevation in all blood count

Question 10

types of True polycythemia ?

Answer 10

1. P rubra vera
2. secondary P

Question 11

when it is relative Polycythemia ?

Answer 11

reduction in the plasma volume

Question 12

causes of pseudo-P ?

Answer 12

• stress
• cigarette
• burns
• dehydration
• reduced fluid intkae

Question 13

CBC of Polycythemia Rubra Vera ?

Answer 13

1. Hb% +
2. PCV +
3. RBC +
4. WBC +
5. P +
6. ESR -

Question 14

BM of PRV ?

Answer 14

1. C= +
2. M/E = Normal
3. E - ERYTHROID hyperplasia
4. G - HYPERACTIVE
5. M -Hyperactive

Question 15

Others test for PRV ??

Answer 15

• 1. janus associated kinase- 2
• loss/gain of C-9
• NAP +
• serum erythropoietin -

Question 16

Causes of PRV ?

Answer 16

1. Hypoxia
2. high altitude
3. heart disease
4. heeavy cigarette smoker
5. high affinity to Hb
6. polycystic kidney disease
7. renal d
8. carcinoma
9. beningn familial polycythemia
10. 2,3 biphosphoglycerate deficiency

Question 17

Diagnosis Triad of PRV ??

Answer 17

1. Splenomegaly
2. elevated Hb with leukocytosis & thrombopcytosis
3. dusky brick red colour of the face = Ruddy cyanosis

Question 18

WHO criteria major for PRV ?

Answer 18

1. JAK-2 mutation
2. Hb% male >18gm/dl
3. female >16gm/dl

Question 19

minor criteria for PRV ?

Answer 19

1. erythropoitin -
2. inc bone marrow proliferation

Question 20

ss of PRV ?

Answer 20

1. thrombosis
2. DVT
3. HTN
4. PVD
5. Hemorrhage
6. hepatosplenomegaly
7. headache
8. dizziness
9. pruritis
10. poor vision