Diseases Of Lymphatics Flashcards
what is lymphadenopathy ??
when 2/more groups of lymph node are enlarged
causes of lymphadenopathy ?
lymphoma
leukaemia
SLE
RA
CMV HIV
Filariaisis
toxoplasmosis
syphilis
TB brucellosis cat scracth D
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Lymphoma defination ?
neoplastic proliferation of cells native to the lymph nodes
WHO classification of hodgkin lymphoma ?
Classical
non-classical
classification of lymphoma ?
Hodgkin
Non-H
Classical HL types >?n
nodular
mixed cellularity
lymphocyte rich
lymphocyte depleted
Non-classical HL ?
lymphocyte predominant
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hall mark of HL ?
RS cells
what is Reed sterberg cells >
malignant lymphoid cells of B cell origin
Major hallmark of HL >
RS cells
pleomorphic infiltration
RS cells diameter ?
45 micro meter
Characteristics of RS cells ?
1.bi-lobed nucleus = two halves = mirror image
2.nucleus = contain = inclusion like nucleolus = surrounded by a clear zone (halo) = owl eye appearance
3.nucleus = surround by T lymphocyte + plasma cells + eosinophilic cytopolasm
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why owl eye appearance??
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nucleus = contain = inclusion like nucleolus = surrounded by a clear zone (halo) = owl eye appearance
lacunar cell in which subtypes ?
nodular sclerosis
nucleus condition in RS cells
3.nucleus = surround by T lymphocyte + plasma cells + eosinophilic cytopolasm
other example of RS cells ?
infectious mononulceosis
CLL
non-HL
solid tissue cancer
RS cells type ?
mononuclear
lacunar
lympho-histocytic
special appearance of RS cells ?
pop-corn cell
why popcorn cell ?
puffy n
abundant pale cytoplasm
= popped corn
lympho-histocytic in which sub-type ?
Lymphocyte predominant
most common subtype ?
nodular sclerosis
HL classification by whom ?>?
WHO
non-HL etiology ?
virus -HCV HHV-8 HIV
what is burkitt lymphoma ?
translocation of the MYC gene on chromosome-8 that lead to inc MYC protein level
RS cell in which process in lympho-histocytic type ?
mummification
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kader hoy ?
HIV pt
children
Burkitt lymphoma kothay hoy ?
Jaw
facial bones
Burkitt lymphoma type ?
B cell lymphoma
T cell lymphoma example ?
Mycosis fungoides
One specific features of BL ?
t-(8-14)
chromosomal translocation
morphology of BL >
Starry sky appearance
inc mitotic index ‘
apoptotic cells
abundant clear cytoplasm
which L high cure rate?
HL
which one is bad ?
non-HL
Lymph node examination of hl >
FNAC
Biopsy
histopathology
FNAC type for HL ?
Excisional / image guided biopsy
CBC of L ?
Platelet = normal
inc ESR
eosniophilia
PBF of L ?
normochromic normocytic
BM of L ?
Leukoerythroblastic blood picture
IHC of L ?
CD - 15 20 30
Lymph node involvement in HL ?
single axial
lymph node involvement in Non-HL ?
Multiple peripheral nodes
extranodal involvemnet less ?
HL
HL vs Non-HL ??????????//
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follicular hyperplasia vs Follicular lymphoma ?
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Systemic features and B symtpoms and Pruritis more common in ?????????/
HL
Mesenteric node
epitrochlear node
weldeyer ring involvement less ?
HL
presence nodal architecture?
f hyperplasia
follicles site in both ?
F h = Follicles - centre
F l = F = centre + medulla
Follicles shape >?
F h = variation in size and shape
F l = uniform
mantle cell in both ?
F h = MC = dictinct
F l = MC = indisxinct
11-2-2025
12.44PM
