spermatogenesis Flashcards

1
Q

Testis sits in?

A

tunica vaginalis, lined by mesothelium cells

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2
Q

veins in spermatic cord are called?

A

pampiniform plexus

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3
Q

testic is covered by thick fibrous capsule called?

A

tunica albuginea

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4
Q

seminiferous tubules converge on?

A

rete testis

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5
Q

Spermatogenesis happens within?

A

seminiferous tubules

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6
Q

leydig cells produce testosterone from?

A

cholesterol and acetate

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7
Q

how much testosterone is produced daily?

A

4 to 10mg

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8
Q

in sertoli cells what happens to testosterone?

A

converted into dihydrotestosterone by 5 alpha reductase

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9
Q

how long are seminiferous tubules?

A

30-80cm

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10
Q

what surrounds seminiferous tubules?

A

peripheral myoid cells for contractility and then basement membrane

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11
Q

in seminiferous tubules there are 2 types of cells?

A

spermatogenic and sertoli cells

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12
Q

Physiological barrier in seminiferous tubules?

A

basal and adluminal compartment, gap and tight junctions between sertoli cells

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13
Q

how much spermatozoa are produced?

A

300 to 600 per gram of testis per second

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14
Q

what happens at puberty in spermatogenesis?

A

germ cells of immature testis, prospermatogonia, are reactivated to undergo rounds of mitosis

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15
Q

where do prospermatogonia do rounds of mitosis?

A

basal compartment of tubule

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16
Q

which cells emerge from prosmatogonia?

A

spermatogonia, produce clone of cells

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17
Q

what emerges from spermatogonia and where do they inhabit?

A

primary spermatocytes, inhabit cytomplasmic cavities in sertoli cells

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18
Q

meiosis occurs in?

A

adluminal compartment

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19
Q

secondary spermatocytes quickly form?

A

haploid spermatids

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20
Q

Unwanted cytoplasm is eaten by what?

A

sertoli cell

21
Q

spermatogenic cycle happens every?

22
Q

total time for completion of spermatogenesis is?

23
Q

where is fluid absorbed and sperm concentrated?

A

in epididymis

24
Q

difference in sperm in rete and epididymis?

A

in rete they twitch, in epididymis they swim, dependent of androgen stimulation

25
cellular components of sperm?
leucocytes, spermatogenic cells, epithelial cells, and spermatozoa
26
fluid components?
nutrition (fructose and sorbitol) buffer against vaginal acidity antioxidants (ascorbic acid and hypotaurine)
27
Mucus is secreted by what?
columnar cells of endocervix
28
how does mucus guide spermatozoa?
mucus has macromolecular network of mucin fibrils
29
how does oestrogen affect mucus?
makes it watery
30
what does progesterone do to mucus?
inhibits secretory activity
31
sperm penetrates on what day?
9 and peaks at time of ovulation
32
capacitation?
stripping glycoprotein from surface, which accumulates in the epididymus, Causes hyperactive motility And makes the sperm responsive to signals from oocyte
33
volume of ejaculation?
1.5 and 6 ml
34
normal conc of sperm?
more than 15 mil per ml
35
vitality of sperm?
58% or more live spermatozoa
36
progressive motility?
32%
37
morphology of sperm?
more than 4%
38
asthenozoospermia?
too little motility
38
asthenozoospermia?
too little motility
39
teratozoospermia?
too many abnormals
40
azoospermia?
no spermatozoa
41
aspermia?
no ejaculate
42
Oligozoospermia?
Low concentration
43
What is important about the last stage of mitosis?
Nuclear division is complete but cytoplasmic division is yet not, hence primary spermatocytes are linked by cytoplasmic bridges
44
What is the acrosome for?
To penetrate the oocyte
45
Additional secretions added to sperm volume are?
3ml
46
Why might volume of ejaculation be low?
Abstinence, accessory gland inflammation
47
What is sperm conc?
Number of sperm per ml in the total ejaculate Normal is over 15 mil per ml