Hormonal Drug Delivery

Question 1

What are excipients?

Answer 1

Water, lactose

Question 2

How to deal with multiple oral dosing?

Answer 2

Sustained release drugs

Question 3

For amino acids and corticosteroids what is does and route?

Answer 3

Orally and low dose

Question 4

Excipients?

Answer 4

Dilutents e.g lactose, water
Surfactants e.g polysorbates
Disintegrates e.g starch bursts tablet apart
Viscosity enhancing e.g cellulose derivatives
Lubricants
Sweeteners
Preservatives

Question 5

Intra-articular injections example?

Answer 5

Hydrocortisone for tennis elbow

Question 6

Creams etc?

Answer 6

Betamethasone for eczema

Question 7

Suppositories?

Answer 7

Hydrocortisone

Question 8

Peptide hormone factor and route?

Answer 8

Not absorbed orally, large molecule, insulin is 5800

Require systemic action, basal and bolus Release

Question 9

Insulin route is?

Answer 9

Subcutaneous but can be inhaled

Question 10

How to make longer lasting?

Answer 10

Change isoelectric point, how quickly the clumps of glargine dissolve, longer lasting sustained release

Question 11

Which drug would be in insulin pump?

Answer 11

The basal more stable one

Question 12

Pulmonary route benefits?

Answer 12

Large surface area, thin epithelial barrier, good blood supply, avoids GI and hepatic metabolism

Question 13

Sex hormones factors?

Answer 13

Well absorbed, extensive first pass metabolism, short half life, low MW.
Avoid oral route

Question 14

Transdermal?

Answer 14

Crossing skin to sight of action e.g patch gel or spray

Question 15

Testosterone is given?

Answer 15

IM injection

Question 16

Nexplanon progesterone release?

Answer 16

Implant

Question 17

Adding ester to testosterone causes?

Answer 17

Decreased water solubility and deactivates, cant bind to receptor
Increases oil solubility
But esterases in blood can restore to bind to receptor

Question 18

Intranasal benefits?

Answer 18

Good blood supply
Large surface area
Avoids hepatic metabolism
Good bioavailability for low MW compounds

Question 19

Disadvantages for intranasal?

Answer 19

Mucociliary clearance
Metabolic activity
Poor bioavailability high MW compounds

Desmopressin

Question 20

How often is mucoadhesive testosterone given?

Answer 20

2x daily

Question 21

Amino acid derivatives are normally given?

Answer 21

Orally

Question 22

Afrezza?

Answer 22

Inhaled insulin, rapid acting, in combination with long acting

Question 23

Implants sustained release of progesterone?

Answer 23

Nexplanon

Question 24

Vaginal ring lasts?

Answer 24

90 days

Question 25

Which drug in IUS?

Answer 25

Levorgestrel, local action for 3-5 years

Thickens cervical mucus
Inhibits sperm from reaching egg
Thins uterine lining

Question 26

Eicosanoids do what?

Answer 26

Ripen cervix before delivery, prostaglandin e2, vaginal pessary or gel

Released over 12 hours

Question 27

For inhalers what do you use?

Answer 27

Beclometasone for asthma

Question 28

What to use for eye drops?

Answer 28

Dexamethsone for inflammation

Question 29

Afrezza?

Answer 29

Rapidly acting inhaled insulin

Before meal

Question 30

In vaginal administration local estring realeases estradiol over?

Answer 30

90 days

Question 31

What is a pessary?

Answer 31

Vaginal tablets of estradiol