Endometrial Cancer

Question 1

What percent of women present with post menopausal bleeding?

Answer 1

80

Question 2

Adenocarcinoma architecture?

Answer 2

Remenants of glands, gland formation different, endothelial cells are irregular big nuclei and irregular

Question 3

Clear cell carcinoma?

Answer 3

Cytoplasm is cleared

Big nuclei and irregular and granular chromatin

Question 4

Serous cancers resemble?

Answer 4

Fallopian tube epithelium

Question 5

Precursor lesion is called?

Answer 5

Cervical intra-epithelial neoplasia

Question 6

How to detect/treat CIN?

Answer 6

Screening for HR HPV infection
Abnormal cells
Examine cervix by colposcopy
Treating by LLETZ

Question 7

Peak incidence of endometrial adenocarcinoma?

Answer 7

55-65 years

Question 8

Lifetime risk of endometrial adenocarcinoma?

Answer 8

1 in 46

Question 9

Risk factors of endometrial cancer?

Answer 9

Endogenous hormone/reproductive factors
Excess body weight
Diabetes mellitus/insulin
Exogenous hormones
Ethnicity
Lynch/cowdens syndrome

Question 10

How does reproduction help against endometrial cancer?

Answer 10

Break from unopposed oestrogen

Removal of abnormal cells

Question 11

What percent of endometrial cancer ar elinked to ecess body weight?

Answer 11

34%

Question 12

Increased risk in overweight women?

Answer 12

2-3

Question 13

Endometrial cancer and diabetes risk?

Answer 13

2 fold

Question 14

Staging system FIGO?

Answer 14

1 confined to corpus
2 involving cervix
3 serosa/adnexa/vagina/lymph nodes
4 bladder bowel or distant

Question 15

Subtypes of endometrial adenocarcinoma?

Answer 15

Endometrioid, serous, clear cell, mixed , undifferentiated, differentiated and carcinosarcomas

Question 16

Which is most common type of adenocarcinoma?

Answer 16

Endometrioid