Appetite And Weight

Question 1

Obesity BMI value

Answer 1

30-39.9

Question 2

Bio electrical impedance analysis?

Answer 2

Pass radio waves through body to calculate how much water, bone etc

Question 3

Pro inflammatory cytokines?

Answer 3

TNF alpha and Il6

Question 4

How many T2DM picked up at routine test?

Answer 4

50%

Question 5

Obstructive sleep apnoea?

Answer 5

Snoring and awake disrupted sleep

Question 6

Diabetes can cause in liver?

Answer 6

Non-alcoholic fatty liver disease, 90% of obese people have it

Question 7

What can NAFLD lead to?

Answer 7

1/5 Non alcoholic steatohepatitis and then 1/5 cirrhosis and chronic liver disease

Question 8

How does obesity cause cancer?

Answer 8

Increased insulin, oestrogen, adipocytokines, IGF-1 and reflux

Question 9

What can obesity cause in reproductive system?

Answer 9

POCS, hypogonadism (low Testosterone conversion to oestrogen), adverse pregnancy outcomes

Question 10

What can obesity cause?

Answer 10

Osteoarthritis, gout

Question 11

Rare genes disorders causing obesity?

Answer 11

Prader willi and Bardet biedl- children keep eating don’t realise

Question 12

Cholecystokinin/PPY?

Answer 12

• dont eat

Question 13

Ghrelin

Answer 13

+ eating

Question 14

Orlistat works by?

Answer 14

Binds and inhibits lipases, prevents hydrolysis of fat into absorbable free fatty acids/glycerol

So you excrete 1/3 of dietary fat

Question 15

Orlistat adverse effects?

Answer 15

Flatulence, diarrhoea, oily faecal leakage,

Less absorption of fat soluble vitamins ADEK, supplements

Question 16

Liraglutide?

Answer 16

GLP 1 receptor agonist
Daily sc injection
NICE say only if
BMI over 35
Risk factors of cardiovascular disease
Tier 3 MDT weight management service

Question 17

Complication of roux en y gastric bypass?

Answer 17

Dumping syndrome: gastric emptying rapid

Post pranial hypoglycaemia

Micronutrient deficiencies: Vitamins calcium iron etc

Question 18

Surgical treatment weight loss?

Answer 18

Weight loss 25-30%

Question 19

Bariatric surgery?

Answer 19

Fail other options
BMI over 40
BMI 35 and other comorbidities

But 2014 expedite over 35 with recent t2d

Question 20

What is pathophysiology of insulin resistance, obesity and metabolic syndrome?

Answer 20

Increased levels of free fatty acids results in gluconeogenesis and dyslipidaemia

Question 21

Proinflammatory markers and obesity?

Answer 21

TNF alpha and IL6 from overloaded white adipose tissue leads to insulin resistance.

Decreased expression of GLUT 4 and tyrosine kinase activity of insulin receptor.

Question 22

PYY signals to?

Answer 22

Not eat

Question 23

Conditions to be given liraglutide?

Answer 23

Bmi over 35
Impaired glucose tolerance
Risk factors for cardiovascular disease

Question 24

Semaglite injection is?

Answer 24

Once weekly

Question 25

Physical activity accounts to what percent of total energy expenditure?

Answer 25

20-50

Question 26

What are NHS guidelines for bariatric surgery?

Answer 26

Must have been obese for at least 5 years

Must engage in non surgical weight loss programme for 12-24 months first
Same as nice

Question 27

Accelerator neurons to eat?

Answer 27

Neuropeptides y

And agouti related peptide

Question 28

Brake neurons of hypothalamus are?

Answer 28

POMC neurons

Question 29

What