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Pharma > SEDATIVE-HYPNOTIC DRUGS > Flashcards

SEDATIVE-HYPNOTIC DRUGS Flashcards

1
Q

Site of action of sedative-hypnotic drugs

A

GABA-A receptor

Functions as a chloride ion channel

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2
Q

Antidote for BZD overdose

A

Flumazenil

BZD receptor antagonist

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3
Q

MOA of BZD

A

Binds to GABA-A receptor to increase FREQUENCY of Cl channel opening

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4
Q

Short-acting BZD used for pre-op sedation

A

Midazolam

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5
Q

This accounts for the short duration of action of short-acting BZDs

A

Rapid tissue redistribution

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6
Q

Short-acting BZD for insomnia

A

Triazolam

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7
Q

Intermediate-acting BZD used for insomnia

A

Estalozam

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8
Q

Intermediate-acting BZD used in STATUS EPILEPTICUS

A

LORAZEPAM

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9
Q

Intermediate-acting BZD for anxiety and panic disorders

A

Clonazepam
Alprazolam

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10
Q

Long-acting BZD used for insomnia

A

Flurazepam

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11
Q

Long-acting BZD used for STATUS EPILEPTICUS

A

Diazepam

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12
Q

Long-acting BZD used in CEREBRAL PALSY

A

Diazepam

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13
Q

Long-acting BZD known as the date rape drug

A

Flunitrazepam

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14
Q

Long-acting BZD with the longest half-life

A

Chlordiapoxide

Only long-acting na may X

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15
Q

Long-acting BZDs used for ALCOHOL WITHDRAWAL

A

Diazepam
Chlordiazepoxide

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16
Q

MOA of Barbiturates

A

Bind to GABA-A receptor to increase DURATION of Cl channel opening

17
Q

Contraindication for Barbiturate use

A

Porphyria

18
Q

Ultrashort-acting barbiturate that is used for anesthesia induction

A

Thiopental

19
Q

Ultrashort-acting barbiturate used for seizure induction for epileptic patients undergoing temporal lobe resection

A

Methohexital

(+) METHODhexital

20
Q

Ultrashort-acting barbiturate which has the highest lipid solubility (rapid entry to brain <1min and rapid awakening)

A

Thiopental

21
Q

Long-acting barbiturate used in GILBERT SYNDROME

A

PHENOBARBITAL

22
Q

Long-acting barbiturate used for seizures in infant

A

Phenobarbital

23
Q

High dose BZD and Barbs may suppress seizure but at the expenses of marked sedation EXCEPT

A

Clonazepam and Phenobarbital

24
Q

Anxiolytic used in GENERALIZED ANXIETY DISORDERS (GAD)

A

Buspirone

25
Q

Anxiolytic that activates melatonin receptors (MT1 & MT2) causing decreased latency of sleep onset

A

Ramelteon

raMELteon

26
Q

DOC for opioid overdose

A

Naloxone

27
Q

DOC for opioid dependence and chronic alcoholism

A

Naltrexone

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