BLOOD Flashcards

1
Q

Iron supplements are under what category?

A

Category A

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2
Q

Chelates excess iron

A

Deferoxamine

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3
Q

Main stimulus for EPO production

A

Hypoxia-inducible factor 1

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4
Q

EPO is under what category?

A

Category C

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5
Q

Myeloid growth factors

A

FilGRASTIM (G-CSF)
SarGRAMOSTIM (GM-CSF)

GRA - granulocyte
STIM - stimulate
GRAM - granulocyte and myeloid

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6
Q

What organ produce thrombopoietin?

A

Liver

EPO -kidney

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7
Q

Megakaryocyte Growth Factor

A

Oprelvekin (IL-11)
TPO
Eltrombopag
Romiplastim

El(TROMBO)PAG - Thrombocyte
Romi(pla)(stim) - platelet stimulator

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8
Q

Used in chronic TTP

A

ELTROMBOPAG

Thrombopoietin-receptor agonist

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9
Q

Irreversible COX 1&2 inhibitor

A

Aspirin (Acetylsalicylic acid, ASA)

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10
Q

Associated with Reye syndrome in children

A

Aspirin

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11
Q

Samter triad

A
  1. Asthma
  2. ASA sensitivity
  3. Nasal polyps
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12
Q

EptiFIBatide
TiroFIBan
Abciximab

A

Glycoprotein IIB/IIIA inhibitor

MOA: interferes with GPIIB/IIIA binding to fibrinogen

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13
Q

Irreversibly inhibits binding of ADP to platelet receptors

A

ADP inhibitors

Clapidogrel
Ticlopidine
Prasugrel
Ticagrelor

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14
Q

ADP inhibitor that causes TTP

A

Ticlopidine

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15
Q

ADP inhibitor that inhibits ADP subtype P2Y - allosteric antagonist

A

Ticagrelor

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16
Q

Inhibits phosphodiesterase III

A

PDE inhibitor

Dypiridamole
Cilostazol

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17
Q

Used only in refractory intermittent claudication in patients with PAD
Contraindicated in heart failure

A

Cilostazol

18
Q

Acid base disorder in ASPIRIN TOXICITY

A

Respiratory alkalosis with HAGMA

19
Q

Management for Heparin-induced thrombocytopenia (HIT)

A

Low molecular weight heparin (LMWH) - Fondaparinux
Direct thrombin inhibitor - Lepirudin

20
Q

Inhibits Vitamin K epoxide reductase

21
Q

Binds to thrombin’s active site

A

Direct thrombin inhibitors (-RUDIN, -GAT)

Lepirudin
Bivalirudin
Argatroban
Dabigatran

22
Q

Parameter used to monitor direct thrombin inhibitors

23
Q

Monoclonal antibody used for reversal of Dabigatran toxicity

A

Idarucizumab

24
Q

Activates antithrombin III

A

Indirect thrombin inhibitors (Heparin, LMWH)

25
DOC for anticoagulation during pregnancy
Heparin
26
Antidote for Heparin toxicity
Protamine sulfate
27
A heparinoid consisting of 80% heparin and 20% dermatan sulfate
Sulodexide
28
Binds and potentiates effect of antithrombin III on factor Xa
Enoxaparin Dalteparin Tinzaparin Fondaparinux XA, PARIN *does not require aPTT monitoring *higher bioavailability and t 1/2
29
Inhibit factor Xa
Oral direct factor Xa inhibitor RivaroXaBAN ApiXaBAN Xa ban!! *used esp after hip or knee surgery
30
Oral anticoagulants
Warfarin Dicumarol
31
Used for chronic anticoagulation except during pregnancy
Warfarin
32
Parameter used to monitor Warfarin
PT
33
Antidote for Warfarin overdose
Vitamin K or FFP
34
Active ingredient of most rat poison
Warfarin
35
Tissue plasminogen activator analaog
Steptokinase Alteplase Urokinase Reteplase
36
Antidote for fibrinolytic drugs
Aminocaproic acid
37
Competitively inhibits plasminogen activation by inhibiting tPA
Antiplasmin drugs: Aminocaproic acid TRANEXAMIC ACID
38
Treatment for ACUTE bleeding episodes
Tranexamic acid
39
Used for prevention of hemorrhagic diatheses in newborns
Vitamin K K1 - Phytonadione K2 - Menaquinone
40
ADH agonists
DVT D - desmopressin V - vasopressin T - terlipressin