BLOOD

Question 1

Iron supplements are under what category?

Answer 1

Category A

Question 2

Chelates excess iron

Answer 2

Deferoxamine

Question 3

Main stimulus for EPO production

Answer 3

Hypoxia-inducible factor 1

Question 4

EPO is under what category?

Answer 4

Category C

Question 5

Myeloid growth factors

Answer 5

FilGRASTIM (G-CSF)
SarGRAMOSTIM (GM-CSF)

GRA - granulocyte
STIM - stimulate
GRAM - granulocyte and myeloid

Question 6

What organ produce thrombopoietin?

Answer 6

Liver

EPO -kidney

Question 7

Megakaryocyte Growth Factor

Answer 7

Oprelvekin (IL-11)
TPO
Eltrombopag
Romiplastim

El(TROMBO)PAG - Thrombocyte
Romi(pla)(stim) - platelet stimulator

Question 8

Used in chronic TTP

Answer 8

ELTROMBOPAG

Thrombopoietin-receptor agonist

Question 9

Irreversible COX 1&2 inhibitor

Answer 9

Aspirin (Acetylsalicylic acid, ASA)

Question 10

Associated with Reye syndrome in children

Answer 10

Aspirin

Question 11

Samter triad

Answer 11

1. Asthma
2. ASA sensitivity
3. Nasal polyps

Question 12

EptiFIBatide
TiroFIBan
Abciximab

Answer 12

Glycoprotein IIB/IIIA inhibitor

MOA: interferes with GPIIB/IIIA binding to fibrinogen

Question 13

Irreversibly inhibits binding of ADP to platelet receptors

Answer 13

ADP inhibitors

Clapidogrel
Ticlopidine
Prasugrel
Ticagrelor

Question 14

ADP inhibitor that causes TTP

Answer 14

Ticlopidine

Question 15

ADP inhibitor that inhibits ADP subtype P2Y - allosteric antagonist

Answer 15

Ticagrelor

Question 16

Inhibits phosphodiesterase III

Answer 16

PDE inhibitor

Dypiridamole
Cilostazol

Question 17

Used only in refractory intermittent claudication in patients with PAD
Contraindicated in heart failure

Answer 17

Cilostazol

Question 18

Acid base disorder in ASPIRIN TOXICITY

Answer 18

Respiratory alkalosis with HAGMA

Question 19

Management for Heparin-induced thrombocytopenia (HIT)

Answer 19

Low molecular weight heparin (LMWH) - Fondaparinux
Direct thrombin inhibitor - Lepirudin

Question 20

Inhibits Vitamin K epoxide reductase

Answer 20

Warfarin

Question 21

Binds to thrombin’s active site

Answer 21

Direct thrombin inhibitors (-RUDIN, -GAT)

Lepirudin
Bivalirudin
Argatroban
Dabigatran

Question 22

Parameter used to monitor direct thrombin inhibitors

Answer 22

aPTT

Question 23

Monoclonal antibody used for reversal of Dabigatran toxicity

Answer 23

Idarucizumab

Question 24

Activates antithrombin III

Answer 24

Indirect thrombin inhibitors (Heparin, LMWH)

Question 25

DOC for anticoagulation during pregnancy

Answer 25

Heparin

Question 26

Antidote for Heparin toxicity

Answer 26

Protamine sulfate

Question 27

A heparinoid consisting of 80% heparin and 20% dermatan sulfate

Answer 27

Sulodexide

Question 28

Binds and potentiates effect of antithrombin III on factor Xa

Answer 28

Enoxaparin
Dalteparin
Tinzaparin
Fondaparinux

XA, PARIN

*does not require aPTT monitoring
*higher bioavailability and t 1/2

Question 29

Inhibit factor Xa

Answer 29

Oral direct factor Xa inhibitor

RivaroXaBAN
ApiXaBAN

Xa ban!!

*used esp after hip or knee surgery

Question 30

Oral anticoagulants

Answer 30

Warfarin
Dicumarol

Question 31

Used for chronic anticoagulation except during pregnancy

Answer 31

Warfarin

Question 32

Parameter used to monitor Warfarin

Answer 32

PT

Question 33

Antidote for Warfarin overdose

Answer 33

Vitamin K or FFP

Question 34

Active ingredient of most rat poison

Answer 34

Warfarin

Question 35

Tissue plasminogen activator analaog

Answer 35

Steptokinase
Alteplase
Urokinase
Reteplase

Question 36

Antidote for fibrinolytic drugs

Answer 36

Aminocaproic acid

Question 37

Competitively inhibits plasminogen activation by inhibiting tPA

Answer 37

Antiplasmin drugs: Aminocaproic acid

TRANEXAMIC ACID

Question 38

Treatment for ACUTE bleeding episodes

Answer 38

Tranexamic acid

Question 39

Used for prevention of hemorrhagic diatheses in newborns

Answer 39

Vitamin K

K1 - Phytonadione
K2 - Menaquinone

Question 40

ADH agonists

Answer 40

DVT

D - desmopressin
V - vasopressin
T - terlipressin