BLOOD Flashcards
Iron supplements are under what category?
Category A
Chelates excess iron
Deferoxamine
Main stimulus for EPO production
Hypoxia-inducible factor 1
EPO is under what category?
Category C
Myeloid growth factors
FilGRASTIM (G-CSF)
SarGRAMOSTIM (GM-CSF)
GRA - granulocyte
STIM - stimulate
GRAM - granulocyte and myeloid
What organ produce thrombopoietin?
Liver
EPO -kidney
Megakaryocyte Growth Factor
Oprelvekin (IL-11)
TPO
Eltrombopag
Romiplastim
El(TROMBO)PAG - Thrombocyte
Romi(pla)(stim) - platelet stimulator
Used in chronic TTP
ELTROMBOPAG
Thrombopoietin-receptor agonist
Irreversible COX 1&2 inhibitor
Aspirin (Acetylsalicylic acid, ASA)
Associated with Reye syndrome in children
Aspirin
Samter triad
- Asthma
- ASA sensitivity
- Nasal polyps
EptiFIBatide
TiroFIBan
Abciximab
Glycoprotein IIB/IIIA inhibitor
MOA: interferes with GPIIB/IIIA binding to fibrinogen
Irreversibly inhibits binding of ADP to platelet receptors
ADP inhibitors
Clapidogrel
Ticlopidine
Prasugrel
Ticagrelor
ADP inhibitor that causes TTP
Ticlopidine
ADP inhibitor that inhibits ADP subtype P2Y - allosteric antagonist
Ticagrelor
Inhibits phosphodiesterase III
PDE inhibitor
Dypiridamole
Cilostazol
Used only in refractory intermittent claudication in patients with PAD
Contraindicated in heart failure
Cilostazol
Acid base disorder in ASPIRIN TOXICITY
Respiratory alkalosis with HAGMA
Management for Heparin-induced thrombocytopenia (HIT)
Low molecular weight heparin (LMWH) - Fondaparinux
Direct thrombin inhibitor - Lepirudin
Inhibits Vitamin K epoxide reductase
Warfarin
Binds to thrombin’s active site
Direct thrombin inhibitors (-RUDIN, -GAT)
Lepirudin
Bivalirudin
Argatroban
Dabigatran
Parameter used to monitor direct thrombin inhibitors
aPTT
Monoclonal antibody used for reversal of Dabigatran toxicity
Idarucizumab
Activates antithrombin III
Indirect thrombin inhibitors (Heparin, LMWH)