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Pharma > ANTI-MYCOBACTERIAL DRUGS > Flashcards

ANTI-MYCOBACTERIAL DRUGS Flashcards

1
Q

Inhibits mycolic acid synthesis

A

Isoniazid

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2
Q

S/e of Isoniazid

A

Neurotoxicity (peripheral neuritis)
Hepatitis

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3
Q

Given to prevent neurotoxicity caused by Isoniazid

A

Pyridoxine (B6)

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4
Q

Isoniazid is a potent CYP450 inducer or inhibitor?

A

Inhibitor

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5
Q

Inhibits DNA-dependent RNA-polymerase

A

Rifampicin

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6
Q

Side effect seen in Rifampicin

A

Red orange urine

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7
Q

Is Rifampicin a potent CYP450 inducer or inhibitor?

A

Inducer

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8
Q

A rifampicin derivative that is not absorbed in the GIT, hence used for the prevention of hepatic encephalopathy and treatment for traveller’s diarrhea

A

Rifaximin

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9
Q

An equally effective anti-TB drug with less drug interaction and is the preferred anti-TB for AIDS patients

A

Rifabutin

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10
Q

Converted to pyrazinoic acid under acidic conditions of macrophage lysosomes

A

Pyrazinamide

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11
Q

Causes non-gouty polyarthritis and asymptomatic hyperuricemia

A

Pyrazinamide

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12
Q

Also known as “sterilizing agent” used during the first 2 months of TB therapy

A

Pyrazinamide

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13
Q

Most hepatotoxic anti-TB drugs

A

Pyrazinamide

P>R>I

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14
Q

Inhibits arabinosyl transferases

A

Ethambutol

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15
Q

Causes visual disturbances such as decreased VA, red-green color blindness, retrobulbar neuritis, and retinal damage

A

Ethambutol

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16
Q

Inhibits protein synthesis by binding to S12 ribosomal subunit

A

Steptomycin

17
Q

Nephrotoxic, ototoxic and can cause CONGENITAL DEAFNESS

A

Streptomycin

18
Q

ALL 1st line anti-TB drugs are bactericidal except: (2)

A

Pyrazinamide (can be bactericidal on actively dividing Mtb)
Ethambutol

19
Q

Anti-Leprosy drug that inhibits folic acid synthesis

A

Dapson

20
Q

Most active drug against M. leprae

A

Dapsone

21
Q

Repository form of Dapsone

A

Acedapsone

22
Q

Anti-leprosy drug that binds to guanine bases in bacterial DNA

A

Clofazimine

23
Q

Used for sulfone-resistant Leprosy

A

Clofazamine

24
Q

S/e of Clofazamine

A

Skin discoloration

Pharma (31 decks)

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