ANTI-MYCOBACTERIAL DRUGS

Question 1

Inhibits mycolic acid synthesis

Answer 1

Isoniazid

Question 2

S/e of Isoniazid

Answer 2

Neurotoxicity (peripheral neuritis)
Hepatitis

Question 3

Given to prevent neurotoxicity caused by Isoniazid

Answer 3

Pyridoxine (B6)

Question 4

Isoniazid is a potent CYP450 inducer or inhibitor?

Answer 4

Inhibitor

Question 5

Inhibits DNA-dependent RNA-polymerase

Answer 5

Rifampicin

Question 6

Side effect seen in Rifampicin

Answer 6

Red orange urine

Question 7

Is Rifampicin a potent CYP450 inducer or inhibitor?

Answer 7

Inducer

Question 8

A rifampicin derivative that is not absorbed in the GIT, hence used for the prevention of hepatic encephalopathy and treatment for traveller’s diarrhea

Answer 8

Rifaximin

Question 9

An equally effective anti-TB drug with less drug interaction and is the preferred anti-TB for AIDS patients

Answer 9

Rifabutin

Question 10

Converted to pyrazinoic acid under acidic conditions of macrophage lysosomes

Answer 10

Pyrazinamide

Question 11

Causes non-gouty polyarthritis and asymptomatic hyperuricemia

Answer 11

Pyrazinamide

Question 12

Also known as “sterilizing agent” used during the first 2 months of TB therapy

Answer 12

Pyrazinamide

Question 13

Most hepatotoxic anti-TB drugs

Answer 13

Pyrazinamide

P>R>I

Question 14

Inhibits arabinosyl transferases

Answer 14

Ethambutol

Question 15

Causes visual disturbances such as decreased VA, red-green color blindness, retrobulbar neuritis, and retinal damage

Answer 15

Ethambutol

Question 16

Inhibits protein synthesis by binding to S12 ribosomal subunit

Answer 16

Steptomycin

Question 17

Nephrotoxic, ototoxic and can cause CONGENITAL DEAFNESS

Answer 17

Streptomycin

Question 18

ALL 1st line anti-TB drugs are bactericidal except: (2)

Answer 18

Pyrazinamide (can be bactericidal on actively dividing Mtb)
Ethambutol

Question 19

Anti-Leprosy drug that inhibits folic acid synthesis

Answer 19

Dapson

Question 20

Most active drug against M. leprae

Answer 20

Dapsone

Question 21

Repository form of Dapsone

Answer 21

Acedapsone

Question 22

Anti-leprosy drug that binds to guanine bases in bacterial DNA

Answer 22

Clofazimine

Question 23

Used for sulfone-resistant Leprosy

Answer 23

Clofazamine

Question 24

S/e of Clofazamine

Answer 24

Skin discoloration