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Pharma > ANTI-PSYCHOTIC AGENTS AND LITHIUM > Flashcards

ANTI-PSYCHOTIC AGENTS AND LITHIUM Flashcards

1
Q

D1 receptor family

A

D1
D4
D5

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2
Q

D2 receptor family

A

D2
D3

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3
Q

D2 receptors are found in:

A

Caudate putamen
Nucleus accumbens
Cerebral cortex
Hypothalamus

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4
Q

Typical anti-psychotics MOA

A

Blocks D2 receptors > 5-HT2 receptors

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5
Q

Classes of typical/classical anti-psychotics and their prototypes

A
  1. Phenothiazines (Chlorpromazine)
  2. Piperidine (Thioridazine)
  3. Butyrophenone (Haloperidol)
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6
Q

Corneal and lens deposits

A

Chlorpromazine

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7
Q

Retinal deposits

A

Thioridazine

thio(RETINAL)dazine

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8
Q

Has the most muscarinic blockade, has the least EPS among typical anti-psychotics

A

Thioridazone

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9
Q

Used also in Huntington and Tourette’s syndrome

A

Haloperidol (Butyrophenone)

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10
Q

Has the highest potential for EPS and neuroleptic malignant syndrome

A

Haloperidol (Butyrophenone)

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11
Q

Least sedating among typical anti-psychotics

A

Haloperidol

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12
Q

DOC for refractory and suicidal schizophrenia

A

CLOZAPINE

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13
Q

Atypical anti-psychotic that causes AGRANULOCYTOSIS

A

CLOZAPINE

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14
Q

Prototype of atypical anti-psychotic

A

CLOZAPINE

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15
Q

Atypical anti-psychotics that has the highest weight gain

A

CLOZAPINE
OLANZAPINE

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16
Q

Antagonism-binding profile of Clozapine

A

D4=A1>5HT2A>D2=D1

17
Q

Atypical anti-psychotic used for sleep promotion and maintenance

A

Quietiapine

18
Q

Atypical anti-psychotic that causes cataracts, priapism, and QT prolongation

A

Quietiapine

19
Q

Only approved anti-psychotic for SCHIZOPHRENIA IN CHILDREN

A

Risperidone

20
Q

Most common s/e of Risperidone

A

Hyperprolactinemia

21
Q

Atypical anti-psychotic that shows the greatest risk for QT prolongation

A

Ziprasidone

Increased mortality in elderly patients with dementia-related pyschosis

22
Q

Atypical anti-psychotic which is a partial agonist at D2 receptor

A

Aripiprazole

23
Q

Atypical anti-psychotic used in MDD, autism, and cocaine dependence

A

Aripiprazole

24
Q

Least sedating atypical anti-psychotic

A

Aripiprazole

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