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Pharma > DMARDs > Flashcards

DMARDs Flashcards

1
Q

Inhibits AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) transformylase and thymidylate synthase

A

Methotrexate

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2
Q

DMARD of choice for Rheumatoid arthritis

A

Methotrexate

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3
Q

Rescue agent of MTX

A

Leucovorin (Folinic acid)

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4
Q

Forms PHOSPHORAMIDE mustard which cross-links DNA to prevent cell replication

A

Cyclophosphamide

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5
Q

Rescue agent of Cyclophosphamide

A

MESNA

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6
Q

Suppression of T-lymphocyte responses to mitogen

A

Cinchona alkaloids:
Chloroquine
Hydroxychloroquine

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7
Q

Binds to TNF-a and prevents it from activating TNF-a receptor

A

TNF-alpha inhibitor

Infliximab
Adalimumab
Etanercept
Certolizumab
Golimumab

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8
Q

Forms 6-thioguanine, suppresing inosinic acid synthesis

A

Azathioprine

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9
Q

Inhibits interleukin-1 and interleukin-2 receptor production

A

Cyclosporine

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10
Q

Inhibits inosine monophosphate dehydrogenase

A

Mycophenolate mofetil

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11
Q

Least toxic for SLE nephritis

A

Mycophenolate mofetil

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12
Q

Inhibits the activation of T cells by binding to CD80 and CD86 on the APC

A

Abatacept

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13
Q

Inhibits dihydroorotate dehydrogenase > decreased synthesis of ribonucleotide and arrest of stimulated cels in the G1 phase of cell growth

A

Leflunomide

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14
Q

CD20 inhibitor

A

Rituximab

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15
Q

Binds to IL-6

A

Tocilizumab

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16
Q

Side effects of this monoclonal antibody includes tuberculosis, fungal, viral, and other opportunistic infections

A

Tocilizumab

17
Q

Monoclonal antibody against IL-17

A

Secukinumab

18
Q

Monoclonal antibody against IL-2

A

Basiliximab

19
Q

Monoclonal antibody against IL-12 & 23

A

Ustekinumab

Pharma (31 decks)

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