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Pharma > HEART FAILURE DRUGS > Flashcards

HEART FAILURE DRUGS Flashcards

1
Q

Cardiac glycosides

A

Digoxin

Digitoxin

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2
Q

Arrhythmogenesis in cardiac glycosides are augmented by:

A

Hypokalemia
Hypomagnesemia
Hypercalcemia

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3
Q

B1 agonist used for CARDIOGENIC SHOCK

A

Dobutamine

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4
Q

Side effects seen in Dobutamine

A

ATE <3

A- Arrhythmias
T - Tachyphylaxis
E - Eosinophilic myocarditis

DOBUTAMINE and DOPAMINE are useful in ACUTE HEART FAILURE

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5
Q

Increases cAMP by inhibiting its breakdown by PDE3 > increase in intracellular Ca

A

PDE inhibitors: Milrinone, Inamrinone

Should not be used in CHRONIC FAILURE d/t increase morbidity and mortality

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6
Q

Drugs that may causes Digoxin toxicity

A

Loop diuretics

Thiazides

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7
Q

Most common ECG change seen in DIGOXIN TOXICITY

A

Premature Ventricular contractions (PVC)

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8
Q

Antiarrhythmic drug of choice for DIGITALIS TOXICITY

A

Lidocaine

Severe cases: Electronic pacemaker

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9
Q

Digoxin antibodies

A

DIGIBIND

If not available: Bile acid-biding resins

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10
Q

Drugs with NARROW THERAPEUTIC INDEX

A

WALA na Cyang Papa VasTeD na

W - Warfarin
A - Aminoglycosides
L - Lithium
A - Amphotericin B

C - Carbamazepine

P - Phenytoin
P - Phenobarbital

V - Vancomycin
T - Theophylline
D - Digoxin

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11
Q

First line therapy for both systolic and diastolic failure

A

Diuretics <3

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12
Q

Diuretics used for immediate reduction of the pulmonary congestion and severe edema associated with ACUTE HEART FAILURE

A

Furosemide

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13
Q

This group of diuretic has a significant long-term benefits and can reduce mortality in CHRONIC FAILURE

A

K-sparing diuretics (Spironolactone, Eplerenone)

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14
Q

First line drug for CHRONIC HEART FAILURE

A

ACE inhibitors

ARBs have the same benefits

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15
Q

Neprilysin-inhibitor

A

Sacubitril

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16
Q

Enzyme responsible for the degradation of ANP and BNP, also degrades bradykinin and is inhibited by Sabubitril-Valsartan

A

Neprilysin enzyme

17
Q

This drug has been proven to improve EF among patients with Chronic HFrEF

A

Sacubitril-Valsartan

18
Q

Drugs that have been shown to improve survival in cases of CHF

A

ABA! Buhay ka pa!

A - ACE inhibitors
B - Beta blockers
A - Aldosterone antagonists

Pharma (31 decks)

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