Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharma > ENDOCRINE PHARMACOLOGY > Flashcards

ENDOCRINE PHARMACOLOGY Flashcards

1
Q

Dopamine agonist > inhibiting prolactin

A

Bromocriptine
Pergolide
Cabergoline
Quinagolide

*category B!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Rare disorder seen in px taking Bromocriptine characterized by burning pain and warmth and redness of the extremities

A

Erythromelalgia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Activates oxytocin receptors > stimulates uterine contraction and labor, milk let down

A

Oxytocin
Demoxytocin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Agonist of peripheral oxytocin receptors

A

Carbetocin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Oxytocin-receptor blocker not yet FDA approved due to increase incidence of infant death rates

A

Atosiban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Selective for V2 receptors
1. Causes insertion of water channels in the CD > water reabsorption
2. Act on extra-renal V2 receptors to increase factor VIII and vWF

A

ADH agonist

DVT

Desmopressin
Vasopressin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

ADH agonist is used in:

A

Central diabetes insipidus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Antagonist at V1 and V2 receptors > increases renal excretion of water

A

ADH antagonist

Conivaptan
Tolvaptan
Lixivaptan

Tol and Lixi: more selective to V2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ADH antagonist drugs are used in what condition?

A

SIADH

May SIADH si Coni :<

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

2 types of Diabetes Insipidus

A
  1. Central DI: deficient secretion of ADH
  2. Nephrogenic DI: end-organ resistance to ADH effects
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

GH agonist that increases release of IGF-1 in the liver and cartilage

A

Somatropin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Recombinant IGF-1

A

Mecasermin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Blood glucose level in GH agonists:

A
  1. Somatropin: HYPERglycemia
  2. Mecasermin: HYPOglycemia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Somatostatin analogs

A

Octreotide
Lantreotide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Supresses the release of GH, glucagon, insulin, IGF-1, serotonin, and GIP

A

Somatostatin (octreotide, lanreotide)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

GH receptor antagonist

A

Pegvisomant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Activates FSH receptors > mimics effects of endogenous FSH

A

FSH analogs

FOLLItropin
Menotopins
UtoFOLLItropins
FOLLItropin beta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Activates LH receptors > mimics effects of endogenous LH

A

LH agonists

Choriogonadotropin alfa - recombinant hCG
Lutropin alfa - recombinant LH
Menotropins - mixture of FSH and LH from postmenopausal women
hCG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

GNRH agonists

A

Leu + -relins

Leuprolide
Gonadorelin
Goserelin
Histrelin
Nafarelin
Triptorelin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Administrations of GnRH agonists

A
  1. Intermittent: increase LH and FSH secretion
  2. Prolonged continuous administration: reduced LH and FSH secretion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

GnRH antagonists

A

Ganirelix
Cetrorelix
Abarelex
Degarelix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

GnRH inhibitor used for prostate cancer

A

Degarelix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

GnRH used to prevent LH surge in controlled ovulation

A

Ganirelix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Hyperthyroidism drug preferred during 1st trimester

A

PTU

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Mainstay treatment for postpartum hyperthyroidism
Methimazole
26
Blocks uptake of iodide by the gland through competitive inhibition of the iodide transport mechanism
Perchlorate Petechnetate Thiocyanate
27
Methimazole is preferred over PTU except in what conditions:
1. 1st trimester pregnancy 2. Thyroid storm 3. Methimazole sensitivity/allergy
28
S/E seen in both PTU and Methimazole
Agranulocytosis
29
Causes APLASIA CUTIS CONGENITA if given during 1st trimester
Methimaxole
30
Emits beta rays causing destruction of thyroid parenchyma
Radioactive iodine
31
Permanent side effect of RAI
Hypothyroidism
32
Radiation exposure of thyroid gland may cause
Papillary thyroid Ca
33
Permanent cure of thyrotoxicosis without surgery
RAI
34
Contraindications of RAI
Pregnant Breastfeeding
35
Inhibits thyroglobulin proteolysis. Used as preparation for surgical thyroidectomy to reduce size and vascularity of thyroid gland
Iodine Potassium iodine Lugol’s solution Potassium iodide saturated solution
36
Block beta receptors, slows pacemaker activity, inhibits peripheral conversion of T4 to T3
Propanolol
37
Activation of nuclear receptors results in gene expression with RNA formation and protein synthesis
Levothyroxine Levothyronine Liotrix
38
Prototype glucocorticoid
Hydrocortisone
39
Glucocorticoid with the highest anti-inflammatory potency
Betamethasone
40
Glucocorticoid with the highest self-retaining potency
Fludrocortisone
41
Behavioral changes secondary to steroid use
Steroid rage
42
Desmolase inhibitor blocking the conversion of cholesterol to pregnenolone
Amino-glutethimide
43
Glucocorticoid synthesis inhibitor abused by body builders to lower circulating levels of cortisol in the body and prevent muscle loss
Anti-glutethimide
44
Inhibits cholesterol side-chain cleavage, cytochrome P450 enzymes
Ketoconazole
45
Alternative to Ketoconazole
Itraconazole
46
Selective inhibitor of steroid 11-hydroxylation
11-B hydroxylase inhibitor Metyrapone
47
Drug of choice for pregnant patients with Cushing’s syndrome
Metyrapone
48
Used for diagnostic testing for adrenal function
Metyrapone
49
Competitive inhibitor at GC receptor and progesterone receptor
Mifepristone
50
Approved abortifacient for medical abortion
Mifepristone
51
Aldosterone precursor
Deoxycorticosterone
52
Clear cell vaginal adenocarcinoma in daughters of mothers who took this drug
Diethylstilbestrol (DES)
53
Progestin used as an appetite stimulant
Megestrol
54
A synthetic steroid with weak estrogenic, progestognenic, and androgenic activity, and hence is an agonist of the estrogen, progesterone, and androgen receptor. It is primarily used in menopausal hormone therapy, post-menopausal osteoporosis and endometriosis
Tibolone
55
Activates estrogen and progesterone receptors, inhibits ovulation, effects on cervical mucus gland, uterine tubes, and endometrium lead to decreased fertility
Combined oral contraceptive
56
Activates progesterone receptors > prevents conception by altering cervical mucus and creating a hostile endometrium
Medroxy-progesterone acetate
57
Used as emergency contraception / post-coital contraceptive
Levonorgestrel Ethinyl estradiol + levonorgestrel
58
Full estrogen receptor antagonist for hormone receptor positive metastatic breast Ca resistant to Tamoxifen
Fluvestrant
59
Estrogen antagonist that increases bone mineral density and is preferred in patient with history of breast cancer in the management of hot flushes
Raloxifene
60
Partial agonist of estrogen receptors in pituitary
Clomiphene Acts as an antagonist to estrogen receptors in the pituitary > inhibit negative feedback mechanism by estrogen > leads to pituitart stimulation causing increase LH and FSH
61
Reduces estrogen synthesis by inhibiting aromatase thich converts testosterone to estrogen. Used in breast cancers resistant to Tamoxifen
Aromatase inhibitor ALE A - anastrozole L - letrozole E - exemestane (irreversible inhibitor)
62
Weak cytochrome P450 inhibitor and partial agonist of progestin and androgen receptors
Danazol
63
This type of drugs causes temporary exacerbation of precocious puberty or prostate cancer, apoplexy, and blindness during the irst few weeks of therapy therefore should be co-administered with Flutamide, an androgen receptor antagonists
GNRH agonists Lueprolide and -relins
64
Pharmacologic antagonist of glucocorticoid and progesterone receptors
Mifepristone
65
Androgen receptor antagonist used in prostate cancer and for surgical castration
Flutamide, Bicalutamide, and Nilutamide Nilutamide (surgical castration)
66
Inhibits 5a-reductase that converts testosterone to dihydrotestosterone, used in BPH and male pattern baldness
5a-reductase inhibitor 1. Finasteride 2. Dutasteride

Pharma (31 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions