DRUGS FOR ANGINA PECTORIS

Question 1

2 therapeutic strategies in Angina

Answer 1

1. Increasing O2 delivery (vasodilation)

2. Reducing O2 requirement (decrease HR)

Question 2

T or F. Nitrates are more of a venodilator than an arteriolar vasodilator.

Answer 2

True!

Question 3

Involved in Monday disease

Answer 3

Nitrate poisoning

Pathopx:
Nitrates release NO > meningeal blood vessel vasodilation > increase in ICP > headache

Question 4

Cyanide affects what complex in ETC?

Answer 4

Complex IV (Cytochrome oxidase)

Question 5

Antidote for Cyanide poisoning is Lilly Cyanide kit which contains:

Answer 5

AN - NT

Amyl Nitrate - inhaled
Sodium Nitrate - IV
Sodium Thiosulfate - IV

Question 6

Combination of these drugs causes VERY DANGEROUS HYPOTENSION

Answer 6

Nitrate + Sildenafil (Phosphodiesterase 5)

Question 7

Side effect of Nitrates that is treated with low dose Methylene blue

Answer 7

Methemoglobinemia

Question 8

Nitrate used in CYANIDE POISONING

Answer 8

Amyl nitrite

Question 9

DOC for PRINZMETAL ANGINA

Answer 9

DILTIAZEM

Question 10

Has pro-arrhythmogenic effect

Answer 10

Dihydropyridine CCBs (-dipines)

Question 11

Inhibits beta oxidation of fatty acids by inhibiting 3-ketoacyl-CoA thiolase

Answer 11

Trimetazidine

META - beta

*interacts with MAOi

Question 12

Reduces late, prolonged Na current in myocardial cells

Answer 12

RANOLAZINE

ra(Na)lazine

Causes QT prolongation

Question 13

Inhibits If Na current in SA node > decreasing HR

Answer 13

Ivabradine