DRUGS FOR DYSLIPIDEMIA

Question 1

MOA of Statins

Answer 1

Inhibits HMG-CoA reductase

Question 2

DOC for HYPERCHOLESTEROLEMIA

Answer 2

STATINS

Question 3

Side effects seen in STATINS

Answer 3

Myopathy

Rhabdomyolysis

Question 4

Statins: prodrugs

Answer 4

Simvastatin
Lovastatin

Simba with Love

Question 5

MOA of Bile acids-binding resins

Answer 5

Binds to bile acids

Question 6

Steatorrhea and malabsorption of Vitamin K seen in what dyslipidemic agent?

Answer 6

Bile acid-binding resin

Question 7

MOA: NPC1L1 transporter inhibitor

Answer 7

Ezetimibe

Ezet1mi1be

Question 8

Cholesterol absorption inhibitor that acts as a cholesterol analog

Answer 8

Sitosterol

Question 9

MOA of Niacin

Answer 9

1. Decreases catabolism of apoA-1

2. Decrease VLDL synthesis and secretion

Question 10

Used as alternative to hypertriglyceridemia (second to FIBRATES)

Answer 10

NIACIN

Question 11

MOA of FIBRATES

Answer 11

Activates PPAR-a > stimulating expression of lipoprotein lipase

Question 12

DOC for hypertriglyceridemia

Answer 12

FIBRATES

2nd: NIACIN

Question 13

Fibrate that was withdrawn from the market due to hepatobiliary ca risk

Answer 13

Clofibrate