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Pharma > DRUGS FOR GOUT > Flashcards

DRUGS FOR GOUT Flashcards

1
Q

NSAID used to initially treat acute gout

A

Indomethacin

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2
Q

Inhibits microtubule assembly and LTB4 production leading to decreased macrophage migration and phagocytosis

A

Colchicine

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3
Q

Adverse effect seen in Colchicine use which signals toxicity

A

Diarrhea

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4
Q

Competes with uric acid for reabsorption in the proximal tubules > increase uric acid excretion

A

Probenecid
Sulfinpyrazone
Fenofibrate
Losartan

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5
Q

Required minimum GFR level prior to Probenecid use

A

GFR 30 ml/min

*also in Colchicine use

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6
Q

Active metabolite (alloxanthine) that IRREVERSIBLY inhibits xanthine oxidase

A

Allopurinol

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7
Q

Nonpurine REVERSIBLE inhibitor of xanthine oxidase

A

Febuxostat

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8
Q

1st line treatment for CHRONIC GOUT

A

Allopurinol

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9
Q

For chronic gout in cases of Allopurinol intolerance

A

Febuxostat

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