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Pharma > CHEMOTHERAPY > Flashcards

CHEMOTHERAPY Flashcards

1
Q

Cell cycle specific G2 phase

A

Bleomycin

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2
Q

M phase

A

VVP

V - Vincristine
V - Vinplastin
P - Paclitaxel

VinVinPac

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3
Q

Cell cycle non-specific

A

Alkylating agents
Antitumor antibiotics
Nitroureas

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4
Q

Nephrotoxic, acoustic nerve damage

A

Cisplatin
Carboplatin

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5
Q

Peripheral neuropathy

A

Vincristine

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6
Q

Cardiotoxic

A

Doxorubicin

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7
Q

Pulmonary fibrosis

A

Bleomycin

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8
Q

Hemorrhagic cystits

A

Cyclophosphamide

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9
Q

Myelosupression

A

Methotrexate
5-FU
6-MP

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10
Q

Side effect of some cancr treatments, causing redness, swelling, and pain on the palms and soles

A

Palmar-plantar erythrodysesthesia/ Hand-foot syndrome

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11
Q

Rescue therapy for Methotrexate

A

Leucovorin

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12
Q

Rescue therapy for Cyclophosphamide

A

MESNA

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13
Q

Rescue therapy for Docorubicin

A

Dexrazoxane

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14
Q

Rescue therapy for Cisplatin

A

Amifostine

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15
Q

Forms DNA cross-links > inhibition of DNA synthesis and function

A

Cyclophosphamide
Cisplatin
Busulfan

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16
Q

Pancreatic cancer

A

Oxaliplatin

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17
Q

Forms hydrogen peroxide, which generates free radicals that cause DNA strand scission

A

Procarbazine
Dacarbaxine
Nitrosoureas

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18
Q

Has the highest carcinogenic potential amongst alkylating agents

A

Procarbazine

ProCARCINOGEN

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19
Q

Pulmonary fibrosis

A

Busulfan

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20
Q

Used in CML and specific to CFU-GM, used as a myelosuppressive agent prior to BM transplant

A

Busulfan

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21
Q

Alkylating agent designed for brain tumors

A

Nitrosoureas

Carmustine

*highly lipophilic, allowing ease of passage through BBB into CNS

22
Q

Prevent microtubule assembly. Acts primarily in M phase. Causes neuropathy

A

Vincristine

23
Q

Prevent microtubule assembly. Acts primarily in M phase. Causes BM supression

A

Vinblastine

BLAST in BM

24
Q

Inhibits DNA topoisomerase II (DNA gyrase)

A

Etoposide

25
Q

Inhibits topoisomerase I

A

Camptothecin

  1. Topotecan
  2. Irinotecan
26
Q

For metastatic colorectal ca

A

Irinotecan

27
Q

Interferes with mitotic spindle by preventing microtubule disassembly into tubulin monomers.

A

Taxanes

Paclitaxel
Docetaxel
Cabazitaxel

28
Q

Inhibits dihydrofolate reductase

A

Methotrexate

29
Q

Used in choriocarcinoma

A

Methotrexate

30
Q

Inhibits de novo purine nucleotide synthesis, activated by HGPRT

A

6-Mercaptopurine

31
Q

Inhibits thymidilate synthase, dihydrofolate reductase, and purine nucleotide synthesis

A

Pemetrexed

32
Q

Used in breast ca, colorectal ca, anal, head and neck ca

A

5-FU

33
Q

Most specific for S phase. Used in Acute Leukemia (AML, ALL) and CML in blast crisis

A

Cytarabine

34
Q

Used in Pancreatic cancer

A

Gemcitabine

35
Q

Anthracycline that intercalates between base pair and inhibits topoisomerase II

A

Doxorubicin

36
Q

Generates free radicals which cause DNA strand breaks. Most specific for the G2 phase

A

Bleomycin

37
Q

Binds to double-stranded DNA

A

Actinomycin D

38
Q

Suppresses inflammation and immune response

A

Prednisone

39
Q

Estrogen antagonist action in breast tissue and CNS. Estrogen agonist effects in uterus, liver, and bone.
For hormone-sensitive breast cancer

A

Tamoxifen
Toremifene

40
Q

ANDROGEN ANTAGONIST: Competitive antagonist at androgen receptor. Used in Prostate cancer

A

Flutamide

41
Q

GnRH

A
42
Q

GnRH analog: Increased LH and FSH secretion with intermittent administration, reduced LH and FSH secretion with prolonged continuous administration

A

Leuprolide
Gonadorelin
Nafarelin

43
Q

Estrogen synthesis inhibitor by inhibiting aromatase

A

ALE

A - Anastrozole
L - Letrozole
E -

44
Q

Tyrosine kinase inhibitors

A

Imatinib

45
Q

Acts against breast cancer cells that over-express the HER-2/neu receptor for epidermal growth factor

A

Trastuzumab

46
Q

Inhibits binding of VEGF to VEGFR leading to inhibition of VEGF signaling.

A

Bevacizumab

BV

47
Q

CD20 inhibitor. Binds to surface protein in NHL cells. Induces complement-mediated lysis, direct cytotoxicity, and induction of apoptosis

A

Rituximab

48
Q

Binds to EGFR and inhibits downstream EGFR signaling. Used in Colorectal cancer

A

Cetuximab

49
Q

Inhibits EGFR tyrosine kinase

A

Erlotinib

E - E

50
Q

Endogenous glycoprotein with antineoplastic, immunosuppressive, and antiviral actions

A

Interferon alpha

51
Q

Hydrolyzes circulating L-asparaginase

A

Asparaginase

52
Q

Allows DNA transcription and differentiation of immature leukemic promyelocyres into mature granulocytes (differentiation therapy). Used in ACUTE PROMYELOCYTIC LEUKEMIA

A

All-trans Retinoic acid (ATRA)

Pharma (31 decks)

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