CHEMOTHERAPY

Question 1

Cell cycle specific G2 phase

Answer 1

Bleomycin

Question 2

M phase

Answer 2

VVP

V - Vincristine
V - Vinplastin
P - Paclitaxel

VinVinPac

Question 3

Cell cycle non-specific

Answer 3

Alkylating agents
Antitumor antibiotics
Nitroureas

Question 4

Nephrotoxic, acoustic nerve damage

Answer 4

Cisplatin
Carboplatin

Question 5

Peripheral neuropathy

Answer 5

Vincristine

Question 6

Cardiotoxic

Answer 6

Doxorubicin

Question 7

Pulmonary fibrosis

Answer 7

Bleomycin

Question 8

Hemorrhagic cystits

Answer 8

Cyclophosphamide

Question 9

Myelosupression

Answer 9

Methotrexate
5-FU
6-MP

Question 10

Side effect of some cancr treatments, causing redness, swelling, and pain on the palms and soles

Answer 10

Palmar-plantar erythrodysesthesia/ Hand-foot syndrome

Question 11

Rescue therapy for Methotrexate

Answer 11

Leucovorin

Question 12

Rescue therapy for Cyclophosphamide

Answer 12

MESNA

Question 13

Rescue therapy for Docorubicin

Answer 13

Dexrazoxane

Question 14

Rescue therapy for Cisplatin

Answer 14

Amifostine

Question 15

Forms DNA cross-links > inhibition of DNA synthesis and function

Answer 15

Cyclophosphamide
Cisplatin
Busulfan

Question 16

Pancreatic cancer

Answer 16

Oxaliplatin

Question 17

Forms hydrogen peroxide, which generates free radicals that cause DNA strand scission

Answer 17

Procarbazine
Dacarbaxine
Nitrosoureas

Question 18

Has the highest carcinogenic potential amongst alkylating agents

Answer 18

Procarbazine

ProCARCINOGEN

Question 19

Pulmonary fibrosis

Answer 19

Busulfan

Question 20

Used in CML and specific to CFU-GM, used as a myelosuppressive agent prior to BM transplant

Answer 20

Busulfan

Question 21

Alkylating agent designed for brain tumors

Answer 21

Nitrosoureas

Carmustine

*highly lipophilic, allowing ease of passage through BBB into CNS

Question 22

Prevent microtubule assembly. Acts primarily in M phase. Causes neuropathy

Answer 22

Vincristine

Question 23

Prevent microtubule assembly. Acts primarily in M phase. Causes BM supression

Answer 23

Vinblastine

BLAST in BM

Question 24

Inhibits DNA topoisomerase II (DNA gyrase)

Answer 24

Etoposide

Question 25

Inhibits topoisomerase I

Answer 25

Camptothecin 1. Topotecan 2. Irinotecan

Question 26

For metastatic colorectal ca

Answer 26

Irinotecan

Question 27

Interferes with mitotic spindle by preventing microtubule disassembly into tubulin monomers.

Answer 27

Taxanes Paclitaxel Docetaxel Cabazitaxel

Question 28

Inhibits dihydrofolate reductase

Answer 28

Methotrexate

Question 29

Used in choriocarcinoma

Answer 29

Methotrexate

Question 30

Inhibits de novo purine nucleotide synthesis, activated by HGPRT

Answer 30

6-Mercaptopurine

Question 31

Inhibits thymidilate synthase, dihydrofolate reductase, and purine nucleotide synthesis

Answer 31

Pemetrexed

Question 32

Used in breast ca, colorectal ca, anal, head and neck ca

Answer 32

5-FU

Question 33

Most specific for S phase. Used in Acute Leukemia (AML, ALL) and CML in blast crisis

Answer 33

Cytarabine

Question 34

Used in Pancreatic cancer

Answer 34

Gemcitabine

Question 35

Anthracycline that intercalates between base pair and inhibits topoisomerase II

Answer 35

Doxorubicin

Question 36

Generates free radicals which cause DNA strand breaks. Most specific for the G2 phase

Answer 36

Bleomycin

Question 37

Binds to double-stranded DNA

Answer 37

Actinomycin D

Question 38

Suppresses inflammation and immune response

Answer 38

Prednisone

Question 39

Estrogen antagonist action in breast tissue and CNS. Estrogen agonist effects in uterus, liver, and bone. For hormone-sensitive breast cancer

Answer 39

Tamoxifen Toremifene

Question 40

ANDROGEN ANTAGONIST: Competitive antagonist at androgen receptor. Used in Prostate cancer

Answer 40

Flutamide

Question 41

GnRH

Question 42

GnRH analog: Increased LH and FSH secretion with intermittent administration, reduced LH and FSH secretion with prolonged continuous administration

Answer 42

Leuprolide Gonadorelin Nafarelin

Question 43

Estrogen synthesis inhibitor by inhibiting aromatase

Answer 43

ALE A - Anastrozole L - Letrozole E -

Question 44

Tyrosine kinase inhibitors

Answer 44

Imatinib

Question 45

Acts against breast cancer cells that over-express the HER-2/neu receptor for epidermal growth factor

Answer 45

Trastuzumab

Question 46

Inhibits binding of VEGF to VEGFR leading to inhibition of VEGF signaling.

Answer 46

Bevacizumab BV

Question 47

CD20 inhibitor. Binds to surface protein in NHL cells. Induces complement-mediated lysis, direct cytotoxicity, and induction of apoptosis

Answer 47

Rituximab

Question 48

Binds to EGFR and inhibits downstream EGFR signaling. Used in Colorectal cancer

Answer 48

Cetuximab

Question 49

Inhibits EGFR tyrosine kinase

Answer 49

Erlotinib E - E

Question 50

Endogenous glycoprotein with antineoplastic, immunosuppressive, and antiviral actions

Answer 50

Interferon alpha

Question 51

Hydrolyzes circulating L-asparaginase

Answer 51

Asparaginase

Question 52

Allows DNA transcription and differentiation of immature leukemic promyelocyres into mature granulocytes (differentiation therapy). Used in ACUTE PROMYELOCYTIC LEUKEMIA

Answer 52

All-trans Retinoic acid (ATRA)