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Pharma > DRUGS IN DIABETES > Flashcards

DRUGS IN DIABETES Flashcards

1
Q

1st generation Sulfonylureas

A

CTT -ides

Chlorpropamide
Tolbutamide
Tolazamide

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2
Q

1st generation SU which are highly protein bound drugs which enhances hypoglycemic effects > high propensity to cause hypoglycemia

A

Tolbutamide
Chlorpropamide

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3
Q

2nd generation SU

A

GGGGG -ide

Glipizide
Glimepiride
Glyburide
Glibenclamide
Glicazide

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4
Q

2nd generation SU that causes cholestatic jaundice

A

Glibenclamide

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5
Q

Meglitinides

A

-glinide

Meglitinide
Repaglinide
Nateglinide
Mitiglinide

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6
Q

Has the lowest risk of developing hypoglycemia since they have short DOA

A

Meglitinides

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7
Q

Used in patients with sulfa allergies

A

Meglitinides

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8
Q

S/e includes UPPER RESPIRATORY TRACT INFECTION

A

Meglitinides

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9
Q

Has the least incidence of hypoglycemia and may be used in CKD patients

A

Nateglinide

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10
Q

DOC for obese patients

A

Metformin

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11
Q

Most common side effect of biguanides

A

GI disturbances

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12
Q

Worse side effect of biguanides

A

Lactic acidosis

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13
Q

Insulin-sparing effect

A

Biguanides (Metformin)

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14
Q

Increase target tissue sensitivity to insulin by activating the peroxisome proliferator-activated receptor-gamma nuclear receptor (PPAR-gamma receptor)

A

Thiazolidinediones

Pioglitazone
Rosiglitazone
Troglitazone

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15
Q

Causes dyslipidemia (⬆️ HDL & LDL, ⬇️ TG)

A

THIAZOLIDINEDIONE

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16
Q

Thiazolidinedione with cardiovascular events (MI)

A

Rosiglitazone

17
Q

Thiazolidinedione that causes hepatotoxicity

A

Troglitazone

18
Q

May increase risk for developing BLADDER CANCER

A

Thiazolidinedione - Pioglitazone

19
Q

Inhibits intestinal a-glucosidases

A

Alpha-glucosidase inhibitors

Acarbose
Miglitol
Voglibose

S/e: gastrointestinal disturbance (flatulence)

20
Q

Activates amylin receptors, has an anoretic effect (stimulates CNS to reduce appetite)

A

Amylin analog

Pramlintide

Used also in T1DM

21
Q

Activates GLP-1 rceptors > reduction of post-meal glucose excursions

A

GLP-1 agonist

Exenatide
Liraglutide

22
Q

Possible THYROID CARCINOMA risk

A

Liraglutide

23
Q

Inhibits dipeptidyl peptidase 4 (DPP-4)

A

DPP-4 inhibitors

Sitagliptin
Saxagliptin
Linagliptin

24
Q

Na-glucose cotransporter 2 (SGLT2) inhibitors

A

Empagliflozin
Dapagliflozin
Canagliflozin

25
Q

S/e of SGLT2 inhibitors

A

UTI

26
Q

Bile acid sequestrant

A

Colesevelam

Pharma (31 decks)

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