ANTI-SEIZURE DRUGS

Question 1

SODIUM CHANNEL BLOCKERS ANTI-SEIZURE DRUGS

Answer 1

1. Hydantoin (Phenytoin)
2. Tricyclic (Carbamazepine)
3. Branched chain FA (Valproic acid)
4. Phenyltriazine (Lamotrigine)

Question 2

Sodium channel blocker anti-seizure drug: s/e gingival hyperplasia

Answer 2

Phenytoin

Question 3

Sodium channel blocker anti-seizure drug: FETAL HYDRANTOIN SYNDROME

Answer 3

Phenytoin

Question 4

Water-soluble prodrug of Phenytoin

Answer 4

Fosphenytoin

Question 5

This sodium channel blocker anti-seizure drug interferes with thyroid function test d/t its affinity to TBG

Answer 5

Phenytoin

Question 6

Most common s/e of PHENYTOIN

Answer 6

Diplopia & ataxia

Question 7

Early side effect seen in Phenytoin

Answer 7

Nystagmus

Question 8

DOC for TRIGEMINAL NEURALGIA

Answer 8

Carbamazepine

Question 9

Most common idiosyncratic reaction seen in Tricyclic anti-seizures (Carbamazepine)

Answer 9

SJS, erythematous rash

Question 10

Most common side effect of TCA (Carbamazepine)

Answer 10

Diplopia and ataxia (same as Phenytoin)

Question 11

Teratogenic effect of Carbamazepine

Answer 11

Spina bifida and craniofacial anomalies

Question 12

Anti-seizure drug that can cause auto-induction (induce its own metabolism)

Answer 12

Carbamazepine (TCA)

Question 13

Branched chain fatty acid anti-seizure drug

Answer 13

Valproic acid

Question 14

Broad spectrum anti-seizure drug

Answer 14

Valproic acid

Question 15

DOC for bipolar disorder

Answer 15

Valproic acid

Question 16

DOC for generalized tonic-clonic seizures and absence seizures

Answer 16

Valproic acid

Question 17

Most common side effect of Valproic acid

Answer 17

GI upset

Question 18

Teratogenic effect seen in Valproic acid use during pregnancy

Answer 18

NTD and spina bifida

Question 19

Valproic acid is a CYP450 inducer or inhibitor?

Answer 19

INHIBITOR

Question 20

Sodium channel blocker anti-seizure drug that only blocks Na channels

Answer 20

Zonisamide

Question 21

Phenyltriazine anti-seizure drug that causes cognitive impairment, confusion, and poor concentration

Answer 21

Zonisamide

Question 22

Used for acute manic phase and as prophylaxis in the depressive phase

Answer 22

Lamotrigine

Question 23

GABAERGIC ANTISEIZURE DRUGS

Answer 23

1. Barbiturates
2. Benzodiazepines

Question 24

DOC for infantile seizures

Answer 24

Barbiturates: Phenobarbital

Question 25

Most frequent unwanted side effect of Barbiturates (Phenobarbital)

Answer 25

Sedation

Question 26

Acute intermittent porphyria as a side effect

Answer 26

Phenobarbital (Barbiturates)

Question 27

Drug of choice for Status epilepticus

Answer 27

Benzodiazepines

Question 28

Can be used for Lennox-gastaut syndrome

Answer 28

1. Benzodiazepines (Clonazepam, Clobazam) 2. Monosaccharide derivative (Topiramate)

Question 29

Type of Calcium channel acted upon by Calcium channel blockers anti-seizure drugs (Ethosuximide)

Answer 29

T-type

Question 30

DOC for absence seizure

Answer 30

ETHOSUXIMIDE

Question 31

DOC for Post-herpetic neuralgia (neuropathic pain)

Answer 31

Gabapentin, pregabalin

Question 32

These anti-seizure drug selectively binds synaptic vesicular protein SV2A

Answer 32

Piracetam drugs (Levetiracetam, brivaracetam)

Question 33

These anti-seizure drugs is neither an inducer nor an inhibitor

Answer 33

Piracetam drugs (Levetiracetam, brivaracetam)

Question 34

Anti-seizure drug with the greatest number of mechanisms of action

Answer 34

Topiramate

Question 35

This drug may cause UROLITHIASIS because it is a weak inhibitor of carbonic anhydrase

Answer 35

Topimarate

Question 36

Causes hepatotoxicity and hematotoxicity

Answer 36

Felbamate