OPIOID ANALGESICS AND ANTAGONISTS

Question 1

MOA of opioids

Answer 1

1. Close voltage-gated Ca2+ channels > reduce transmitter release
2. Open K+ channels > hyperpolarization > inhibit post synaptic neurons

Question 2

Opioid side effects with minimal to no tolerance

Answer 2

MCC

M - Miosis
C - Convulsions
C - Constipation

Question 3

Triad of opioid overdose

Answer 3

1. Miosis
2. Coma
3. Respiratory depression

Question 4

Opioid that has the shortest life

Answer 4

Remifentanil

Question 5

Opioid that has the longest half-life

Answer 5

Buprenorphine