ANTIPROTOZOAL DRUGS

Question 1

Anti-malarial drug:
Prevents polymerization of heme into hemozoin

Answer 1

Chloroquine

Question 2

S/e seen in Chloroquine

Answer 2

Retinal damage and auditory impairment
May precipitate porphyria

Question 3

Anti-malaria: Complexes with DNA to prevent strand separation

Answer 3

Quinine
Quinidine

Question 4

S/e seen in Quinine, Quinidine

Answer 4

Blackwater fever
Cinchonism

Question 5

DOC for malaria in pregnant patients

Answer 5

Quinine
Quinidine

Question 6

Used in Chloroquine-resistant areas

Answer 6

Mefloquine

Question 7

Anti-malarial that forms electron-transferring redox compounds that act as cellular oxidants. Eradicates hypnozoites in the liver, preventing malarial relapse (Radical cure of P. vivax and P. ovale)

Answer 7

Primaquine

Question 8

Treatment and prophylaxis of all stages of Chloroquine-resistant P. falciparum

Answer 8

Atovaquone-proguanil

Question 9

Sporonticides

Answer 9

Proguanil
Pyrimethamine

Question 10

Anti-malarial agent that impairs progeny of malarial apicoplast genes > abnormal cell division. Used as chemoprophylaxis in multidrug-resistant malaria.

Answer 10

Doxycycline

Question 11

DOC for uncomplicated falciparum malaria in the Philippines

Answer 11

Arthemeter-Lumefantrine (Co-artem)

Question 12

Current first-line malaria treatment recommended by WHO for children, adults, and pregnant women in 2nd and 3rd trimester

Answer 12

Artemisinin-based combination therapy

Question 13

DOC for asymptomatic cyst carriers of E. histolytica

Answer 13

Diloxanide furoate

Question 14

Used in combination with Metronidazole in mild to severe intestinal amebiasis

Answer 14

Iodoquinol

Question 15

Luminal amebicide that inhibits protein synthesis by binding to 16S ribosomal subunit

Answer 15

Paromomycin

Question 16

Tissue amebicide that causes reactive reduction by ferredoxin forming free radicals that disrupt ETC

Answer 16

Metronidazole

Question 17

DOC for cryptosporidiosis and in Metronidazole-resistant amebiasis

Answer 17

Nitazoxanide

Question 18

Tissue amebicides inhibit protein synthesis by blocking ribosomal movement along messenger RNA

Answer 18

Emetine

Question 19

DOC for the treatment of P. jiroveci pneumocytosis. Used as prophylaxis for Toxoplasmosis and Isosporiasis

Answer 19

Co-trimoxazole

Question 20

DOC for Toxoplasmosis

Answer 20

Sulfadiazine-pyrimethamine

Question 21

Drug for trypanosomiasis that inhibits glycolysis or interferes with nucleic acid metabolism

Answer 21

Pentamidine
Suramin

GLYCOLYSIS

Suramin - sugar
Pentamidine - pentose

Question 22

Drug for trypanosomiasis that acts as a suicide inhibitor of ornithine decarboxylase

Answer 22

Eflornithine

Can pass the BBB - effort si Eflort

Question 23

Inhibits enzyme sulfhydryl groups in trypanosomes

Answer 23

Melarsoprol

Question 24

DOC for Leishmania that inhibits trypanothione reductase

Answer 24

Nifurtimox

Question 25

Antihelminthic drug that increases membrane permeability to calcium causing paralysis

Answer 25

Praziquantel Qualcium

Question 26

DOC for trematodes and cestodes

Answer 26

Praziquantel

Question 27

Antihelminthic drug contraindicated in ocular cysticercosis

Answer 27

Praziquantel

Question 28

Antihelminthic drug that uncouples oxidative phosphorylation or by activating ATPases

Answer 28

Niclosamide

Question 29

Alternative drug for Cestodes

Answer 29

NiClosamide

Question 30

MOA of anti-nematodes

Answer 30

Microtubule inhibitors

Question 31

DOC for Hydatid cyste, ascariasis, hookworm, whipworm, CVLM, cysticercosis, Angiostrongylus, and Capillariasis

Answer 31

Albendazole

Question 32

DOC for cysticercosis

Answer 32

Albendazole Improved penetration of subarachnoid space than Praziquantel in neurocysticercosis

Question 33

DOC for whipworm infections

Answer 33

Mebendazole Me BEND for the whip AYYYYoops

Question 34

DOC for Trichinosis

Answer 34

Thiabendazole

Question 35

DOC for filariasis and eye worm disease

Answer 35

Diethylcarbamazine (DEC)

Question 36

Exhibits Mazzotti reaction when used for Onchocerciasis

Answer 36

Diethylcarbamazine (DEC)

Question 37

DOC for strongyloidiasis and onchocerciasis

Answer 37

Ivermectin S/e: mazzotti reaction, corneal opacities

Question 38

DOC for pinworm infections

Answer 38

Pyrantel pamoate Stimulate nicotinic receptors