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Pharma > ANTIPROTOZOAL DRUGS > Flashcards

ANTIPROTOZOAL DRUGS Flashcards

1
Q

Anti-malarial drug:
Prevents polymerization of heme into hemozoin

A

Chloroquine

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2
Q

S/e seen in Chloroquine

A

Retinal damage and auditory impairment
May precipitate porphyria

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3
Q

Anti-malaria: Complexes with DNA to prevent strand separation

A

Quinine
Quinidine

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4
Q

S/e seen in Quinine, Quinidine

A

Blackwater fever
Cinchonism

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5
Q

DOC for malaria in pregnant patients

A

Quinine
Quinidine

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6
Q

Used in Chloroquine-resistant areas

A

Mefloquine

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7
Q

Anti-malarial that forms electron-transferring redox compounds that act as cellular oxidants. Eradicates hypnozoites in the liver, preventing malarial relapse (Radical cure of P. vivax and P. ovale)

A

Primaquine

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8
Q

Treatment and prophylaxis of all stages of Chloroquine-resistant P. falciparum

A

Atovaquone-proguanil

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9
Q

Sporonticides

A

Proguanil
Pyrimethamine

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10
Q

Anti-malarial agent that impairs progeny of malarial apicoplast genes > abnormal cell division. Used as chemoprophylaxis in multidrug-resistant malaria.

A

Doxycycline

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11
Q

DOC for uncomplicated falciparum malaria in the Philippines

A

Arthemeter-Lumefantrine (Co-artem)

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12
Q

Current first-line malaria treatment recommended by WHO for children, adults, and pregnant women in 2nd and 3rd trimester

A

Artemisinin-based combination therapy

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13
Q

DOC for asymptomatic cyst carriers of E. histolytica

A

Diloxanide furoate

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14
Q

Used in combination with Metronidazole in mild to severe intestinal amebiasis

A

Iodoquinol

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15
Q

Luminal amebicide that inhibits protein synthesis by binding to 16S ribosomal subunit

A

Paromomycin

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16
Q

Tissue amebicide that causes reactive reduction by ferredoxin forming free radicals that disrupt ETC

A

Metronidazole

17
Q

DOC for cryptosporidiosis and in Metronidazole-resistant amebiasis

A

Nitazoxanide

18
Q

Tissue amebicides inhibit protein synthesis by blocking ribosomal movement along messenger RNA

A

Emetine

19
Q

DOC for the treatment of P. jiroveci pneumocytosis. Used as prophylaxis for Toxoplasmosis and Isosporiasis

A

Co-trimoxazole

20
Q

DOC for Toxoplasmosis

A

Sulfadiazine-pyrimethamine

21
Q

Drug for trypanosomiasis that inhibits glycolysis or interferes with nucleic acid metabolism

A

Pentamidine
Suramin

GLYCOLYSIS

Suramin - sugar
Pentamidine - pentose

22
Q

Drug for trypanosomiasis that acts as a suicide inhibitor of ornithine decarboxylase

A

Eflornithine

Can pass the BBB - effort si Eflort

23
Q

Inhibits enzyme sulfhydryl groups in trypanosomes

A

Melarsoprol

24
Q

DOC for Leishmania that inhibits trypanothione reductase

A

Nifurtimox

25
Q

Antihelminthic drug that increases membrane permeability to calcium causing paralysis

A

Praziquantel

Qualcium

26
Q

DOC for trematodes and cestodes

A

Praziquantel

27
Q

Antihelminthic drug contraindicated in ocular cysticercosis

A

Praziquantel

28
Q

Antihelminthic drug that uncouples oxidative phosphorylation or by activating ATPases

A

Niclosamide

29
Q

Alternative drug for Cestodes

A

NiClosamide

30
Q

MOA of anti-nematodes

A

Microtubule inhibitors

31
Q

DOC for Hydatid cyste, ascariasis, hookworm, whipworm, CVLM, cysticercosis, Angiostrongylus, and Capillariasis

A

Albendazole

32
Q

DOC for cysticercosis

A

Albendazole

Improved penetration of subarachnoid space than Praziquantel in neurocysticercosis

33
Q

DOC for whipworm infections

A

Mebendazole

Me BEND for the whip AYYYYoops

34
Q

DOC for Trichinosis

A

Thiabendazole

35
Q

DOC for filariasis and eye worm disease

A

Diethylcarbamazine (DEC)

36
Q

Exhibits Mazzotti reaction when used for Onchocerciasis

A

Diethylcarbamazine (DEC)

37
Q

DOC for strongyloidiasis and onchocerciasis

A

Ivermectin

S/e: mazzotti reaction, corneal opacities

38
Q

DOC for pinworm infections

A

Pyrantel pamoate

Stimulate nicotinic receptors

Pharma (31 decks)

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