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Pharma > ANTI-FUNGAL AGENTS > Flashcards

ANTI-FUNGAL AGENTS Flashcards

1
Q

Interferes with microtubule function

A

Griseofulvin

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2
Q

Anti-fungal contraindicated in patients with Porphyria

A

Griseofulvin

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3
Q

Absorption of this antifungal is increased by intake of fatty meal

A

Griseofulvin

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4
Q

Interfere with ergosterol synthesis by inihibiting squaline oxidase

A

Terbinafine

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5
Q

Binds to ergosterol in fungal cell membranes > forming ARTIFICIAL PORES

A

POLYENE

Nystatin
Amphotericin B

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6
Q

Topical anti-fungal that causes severe nephrotoxicity

A

Nystatin

N-N

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7
Q

Inhibit fungal P450-dependent enzymes blocking ergosterol synthetic

A

Azole

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8
Q

Limited to topical use only because of systemic toxicity

A

Ketoconazole

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9
Q

Systemic anti-fungal drug that causes Renal tubular acidosis with magnesium and potassium-wasting

A

Amphotericin B

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10
Q

Antifungal with the WIDEST antifungal spectrum

A

Amphotericin B

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11
Q

Accumulates in fungal cells by the action of permease and converted by cytosine deaminase to 5-FU > which inhibits thimidylate synthase

A

Flucytosin

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12
Q

Azole with narrow spectrum and high drug-drug interactions

A

Ketoconazole

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13
Q

Azole with broad spectrum and good CNS penetration

A

FPV

Fluconazole
Posaconazole
Voriconazole

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14
Q

Alternative to Amphotercin B in the treatment of Cryptococcal meningitis

A

Fluconazole

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15
Q

Azole with the broadest spectrum and the only azole with activity agaisnt Rhizopus sp. (MUCORMYCOSIS)

A

Posaconazole

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16
Q

Broad spectrum azole with POOR CNS penetration

A

Itraconazole

17
Q

Inhibits B-glucan synthase

A

Echinocandins

Caspofungin
Micafungin
Anidulafungin

18
Q

Salvage therapy for invasive aspergillosis

A

Echinocandin

Caspofungin

19
Q

Causes fever, flushing due to histamine release, and elevated liver enzyme

A

Echinocandin

Caspofungin

Pharma (31 decks)

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